Basic Information:

  VIRBase ID:  

HHID00011682

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:  MIMAT0004593          PLXNC1:  NR_037687     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-130a-5p	PLXNC1
miRBase Accession/Entrez ID	MIMAT0004593	10154
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD232//PLXN-C1//VESPR

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-130a-5p	rs746985078 chr11:57641223    A/G rs779670380 chr11:57641222    C/T rs758215186 chr11:57641219    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PLXNC1	chr12:94587769(+) A-I      intronic chr12:94587762(+) A-I      intronic chr12:94584158(+) A-I      intronic chr12:94549929(+) A-I      intronic chr12:94549935(+) A-I      intronic chr12:94568078(+) A-I      intronic chr12:94584092(+) A-I      intronic chr12:94582192(+) A-I      intronic chr12:94582160(+) A-I      intronic chr12:94647562(+) A-I      intronic chr12:94647576(+) A-I      intronic chr12:94576151(+) A-I      intronic chr12:94576149(+) A-I      intronic chr12:94576114(+) A-I      intronic chr12:94576100(+) A-I      intronic chr12:94576456(+) A-I      intronic chr12:94607736(+) A-I      intronic chr12:94583325(+) A-I      intronic chr12:94608097(+) A-I      intronic chr12:94646734(+) A-I      intronic chr12:94609993(+) A-I      intronic chr12:94575018(+) A-I      intronic chr12:94608098(+) A-I      intronic chr12:94585331(+) A-I      intronic chr12:94672618(+) A-I      intronic chr12:94647702(+) A-I      intronic chr12:94585304(+) A-I      intronic chr12:94568035(+) A-I      intronic chr12:94550711(+) A-I      intronic chr12:94607782(+) A-I      intronic chr12:94585310(+) A-I      intronic chr12:94583433(+) A-I      intronic chr12:94645509(+) A-I      intronic chr12:94647472(+) A-I      intronic chr12:94645637(+) A-I      intronic chr12:94607776(+) A-I      intronic chr12:94647639(+) A-I      intronic chr12:94687556(+) A-I      intronic chr12:94672627(+) A-I      intronic chr12:94584037(+) A-I      intronic chr12:94646928(+) A-I      intronic chr12:94646880(+) A-I      intronic chr12:94607960(+) A-I      intronic chr12:94607743(+) A-I      intronic chr12:94568073(+) A-I      intronic chr12:94607742(+) A-I      intronic chr12:94585417(+) A-I      intronic chr12:94607973(+) A-I      intronic chr12:94646856(+) A-I      intronic chr12:94606589(+) A-I      intronic chr12:94606625(+) A-I      intronic chr12:94606707(+) A-I      intronic chr12:94576280(+) A-I      intronic chr12:94585374(+) A-I      intronic chr12:94653607(+) A-I      intronic chr12:94583191(+) A-I      intronic chr12:94647616(+) A-I      intronic chr12:94583223(+) A-I      intronic chr12:94609843(+) A-I      intronic chr12:94636108(+) A-I      intronic chr12:94575015(+) A-I      intronic chr12:94576079(+) A-I      intronic chr12:94593696(+) A-I      intronic chr12:94643386(+) A-I      intronic chr12:94576057(+) A-I      intronic chr12:94582280(+) A-I      intronic chr12:94583357(+) A-I      intronic chr12:94583440(+) A-I      intronic chr12:94644521(+) A-I      intronic chr12:94583388(+) A-I      intronic chr12:94583296(+) A-I      intronic chr12:94588455(+) A-I      intronic chr12:94574992(+) A-I      intronic chr12:94583197(+) A-I      intronic chr12:94575085(+) A-I      intronic chr12:94575043(+) A-I      intronic chr12:94576109(+) A-I      intronic chr12:94584193(+) A-I      intronic chr12:94584279(+) A-I      intronic chr12:94550675(+) A-I      intronic chr12:94575041(+) A-I      intronic chr12:94575076(+) A-I      intronic chr12:94646937(+) A-I      intronic chr12:94585469(+) A-I      intronic chr12:94575084(+) A-I      intronic chr12:94647675(+) A-I      intronic chr12:94654086(+) A-I      intronic chr12:94585305(+) A-I      intronic chr12:94585440(+) A-I      intronic chr12:94647683(+) A-I      intronic chr12:94647575(+) A-I      intronic chr12:94584041(+) A-I      intronic chr12:94576119(+) A-I      intronic chr12:94647729(+) A-I      intronic chr12:94584145(+) A-I      intronic chr12:94609963(+) A-I      intronic chr12:94584200(+) A-I      intronic chr12:94582229(+) A-I      intronic chr12:94645703(+) A-I      intronic chr12:94643193(+) A-I      intronic chr12:94575016(+) A-I      intronic chr12:94576344(+) A-I      intronic chr12:94645603(+) A-I      intronic chr12:94583297(+) A-I      intronic chr12:94610032(+) A-I      intronic chr12:94585481(+) A-I      intronic chr12:94585439(+) A-I      intronic chr12:94575003(+) A-I      intronic chr12:94574988(+) A-I      intronic chr12:94643356(+) A-I      intronic chr12:94590239(+) A-I      intronic chr12:94588014(+) A-I      intronic chr12:94607930(+) A-I      intronic chr12:94549958(+) A-I      intronic chr12:94587734(+) A-I      intronic chr12:94584148(+) A-I      intronic chr12:94584291(+) A-I      intronic chr12:94585351(+) A-I      intronic chr12:94607962(+) A-I      intronic chr12:94643366(+) A-I      intronic chr12:94583246(+) A-I      intronic chr12:94582118(+) A-I      intronic chr12:94584285(+) A-I      intronic chr12:94584252(+) A-I      intronic chr12:94609994(+) A-I      intronic chr12:94590297(+) A-I      intronic chr12:94568038(+) A-I      intronic chr12:94647615(+) A-I      intronic chr12:94609792(+) A-I      intronic chr12:94654036(+) A-I      intronic chr12:94576264(+) A-I      intronic chr12:94576372(+) A-I      intronic chr12:94587726(+) A-I      intronic chr12:94575053(+) A-I      intronic chr12:94645674(+) A-I      intronic chr12:94574998(+) A-I      intronic chr12:94575070(+) A-I      intronic chr12:94587875(+) A-I      intronic chr12:94647599(+) A-I      intronic chr12:94548152(+) A-I      intronic chr12:94583376(+) A-I      intronic chr12:94584144(+) A-I      intronic chr12:94590025(+) A-I      intronic chr12:94583309(+) A-I      intronic chr12:94590149(+) A-I      intronic chr12:94646733(+) A-I      intronic chr12:94584039(+) A-I      intronic chr12:94585340(+) A-I      intronic chr12:94675462(+) A-I      intronic chr12:94575014(+) A-I      intronic chr12:94593671(+) A-I      intronic chr12:94583419(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PLXNC1	chr12:94574988(+) A-I intron -    15342557 chr12:94574992(+) A-I intron -    15342557 chr12:94574998(+) A-I intron -    15342557 chr12:94575003(+) A-I intron -    15342557 chr12:94575014(+) A-I intron -    15342557 chr12:94575041(+) A-I intron -    15342557 chr12:94575043(+) A-I intron -    15342557 chr12:94575053(+) A-I intron -    15342557 chr12:94575070(+) A-I intron -    15342557 chr12:94575076(+) A-I intron -    15342557 chr12:94575085(+) A-I intron -    15342557 chr12:94576057(+) A-I intron -    15342557 chr12:94576079(+) A-I intron -    15342557 chr12:94576109(+) A-I intron -    15342557 chr12:94576119(+) A-I intron -    15342557 chr12:94587726(+) A-G intron -    22484847 chr12:94587734(+) A-G intron -    22484847 chr12:94583388(+) A-G intron -    22484847 chr12:94583419(+) A-G intron -    22484847 chr12:94585374(+) A-G intron -    22484847 chr12:94675476(+) T-C intron -    22484847 chr12:94675486(+) T-C intron -    22484847 chr12:94675488(+) T-C intron -    22484847 chr12:94568038(+) A-G intron -    22484847 chr12:94582280(+) A-G intron -    22484847 chr12:94584144(+) A-G intron -    22484847 chr12:94584145(+) A-G intron -    22484847 chr12:94584148(+) A-G intron -    22484847 chr12:94584279(+) A-G intron -    22484847 chr12:94585351(+) A-G intron -    22484847 chr12:94585439(+) A-G intron -    22484847 chr12:94585440(+) A-G intron -    22484847 chr12:94607962(+) A-G intron -    22484847 chr12:94609963(+) A-G intron -    22484847 chr12:94644521(+) A-G intron -    22484847 chr12:94647616(+) A-G intron -    22484847 chr12:94674850(+) T-C intron -    22484847 chr12:94674852(+) T-C intron -    22484847 chr12:94677668(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PLXNC1	chr12:94542943-94542944(+) m6A CDS       25456834//22608085 chr12:94542952-94542953(+) m6A CDS       25456834//22608085 chr12:94542991-94542992(+) m6A CDS       25456834//22608085 chr12:94543128-94543129(+) m6A CDS       - chr12:94543261-94543262(+) m6A CDS       - chr12:94543372-94543373(+) m6A CDS       25456834//24981863 chr12:94543783-94543784(+) m6A CDS       - chr12:94544612-94544613(+) m6A exon//intron       - chr12:94544638-94544639(+) m6A exon//intron       - chr12:94563022-94563023(+) m6A CDS//exon       - chr12:94563027-94563028(+) m6A CDS//exon       - chr12:94700314-94700315(+) m6A 3'UTR       27773535 chr12:94700328-94700329(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-130a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	PLXNC1	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-130a-5p	Eloxatine 5310940 Drug interaction    RC00006934 5-Fluorouracil 3385 Drug interaction    RC00006933

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-130a-5p	Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-130a-5p
Interactor2: PLXNC1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).