Basic Information:

  VIRBase ID:  

HHID00011665

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:  MIMAT0004593          KDM4A:  NM_014663     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-130a-5p	KDM4A
miRBase Accession/Entrez ID	MIMAT0004593	9682
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	JHDM3A//JMJD2//JMJD2A//TDRD14A

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-130a-5p	rs746985078 chr11:57641223    A/G rs779670380 chr11:57641222    C/T rs758215186 chr11:57641219    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KDM4A	chr1:44142092(+) A-I      intronic chr1:44141629(+) A-I      intronic chr1:44168873(+) A-I      intronic chr1:44168865(+) A-I      intronic chr1:44168887(+) A-I      intronic chr1:44142192(+) A-I      intronic chr1:44124903(+) A-I      intronic chr1:44127025(+) A-I      intronic chr1:44127304(+) A-I      intronic chr1:44128025(+) A-I      intronic chr1:44128026(+) A-I      intronic chr1:44128103(+) A-I      intronic chr1:44128233(+) A-I      intronic chr1:44128248(+) A-I      intronic chr1:44129525(+) A-I      intronic chr1:44129526(+) A-I      intronic chr1:44129539(+) A-I      intronic chr1:44129543(+) A-I      intronic chr1:44129585(+) A-I      intronic chr1:44129976(+) A-I      intronic chr1:44129983(+) A-I      intronic chr1:44152039(+) A-I      intronic chr1:44138305(+) A-I      intronic chr1:44138372(+) A-I      intronic chr1:44139740(+) A-I      intronic chr1:44140252(+) A-I      intronic chr1:44140288(+) A-I      intronic chr1:44140388(+) A-I      intronic chr1:44141592(+) A-I      intronic chr1:44141593(+) A-I      intronic chr1:44141594(+) A-I      intronic chr1:44141597(+) A-I      intronic chr1:44141623(+) A-I      intronic chr1:44141640(+) A-I      intronic chr1:44141704(+) A-I      intronic chr1:44141707(+) A-I      intronic chr1:44142048(+) A-I      intronic chr1:44142057(+) A-I      intronic chr1:44142072(+) A-I      intronic chr1:44142097(+) A-I      intronic chr1:44142157(+) A-I      intronic chr1:44142158(+) A-I      intronic chr1:44142172(+) A-I      intronic chr1:44142181(+) A-I      intronic chr1:44142189(+) A-I      intronic chr1:44151267(+) A-I      intronic chr1:44151300(+) A-I      intronic chr1:44168455(+) A-I      intronic chr1:44152188(+) A-I      intronic chr1:44124742(+) A-I      intronic chr1:44124713(+) A-I      intronic chr1:44123923(+) A-I      intronic chr1:44152260(+) A-I      intronic chr1:44168771(+) A-I      intronic chr1:44152269(+) A-I      intronic chr1:44166723(+) A-I      intronic chr1:44166812(+) A-I      intronic chr1:44168430(+) A-I      intronic chr1:44168464(+) A-I      intronic chr1:44168518(+) A-I      intronic chr1:44168563(+) A-I      intronic chr1:44168587(+) A-I      intronic chr1:44168623(+) A-I      intronic chr1:44168743(+) A-I      intronic chr1:44168753(+) A-I      intronic chr1:44124789(+) A-I      intronic chr1:44168795(+) A-I      intronic chr1:44168812(+) A-I      intronic chr1:44129988(+) A-I      intronic chr1:44137908(+) A-I      intronic chr1:44127845(+) A-I      intronic chr1:44141497(+) A-I      intronic chr1:44142133(+) A-I      intronic chr1:44142093(+) A-I      intronic chr1:44127614(+) A-I      intronic chr1:44124447(+) A-I      intronic chr1:44129395(+) A-I      intronic chr1:44129960(+) A-I      intronic chr1:44127635(+) A-I      intronic chr1:44126914(+) A-I      intronic chr1:44123853(+) A-I      intronic chr1:44152205(+) A-I      intronic chr1:44168875(+) A-I      intronic chr1:44142762(+) A-I      intronic chr1:44127162(+) A-I      intronic chr1:44142896(+) A-I      intronic chr1:44123880(+) A-I      intronic chr1:44124865(+) A-I      intronic chr1:44139875(+) A-I      intronic chr1:44142869(+) A-I      intronic chr1:44127030(+) A-I      intronic chr1:44141918(+) A-I      intronic chr1:44139622(+) A-I      intronic chr1:44153844(+) A-I      intronic chr1:44139753(+) A-I      intronic chr1:44130000(+) A-I      intronic chr1:44137960(+) A-I      intronic chr1:44141953(+) A-I      intronic chr1:44123870(+) A-I      intronic chr1:44142809(+) A-I      intronic chr1:44168678(+) A-I      intronic chr1:44127682(+) A-I      intronic chr1:44168683(+) A-I      intronic chr1:44124434(+) A-I      intronic chr1:44127691(+) A-I      intronic chr1:44141621(+) A-I      intronic chr1:44127198(+) A-I      intronic chr1:44142131(+) A-I      intronic chr1:44137883(+) A-I      intronic chr1:44128159(+) A-I      intronic chr1:44138132(+) A-I      intronic chr1:44127633(+) A-I      intronic chr1:44168516(+) A-I      intronic chr1:44144384(+) A-I      intronic chr1:44142121(+) A-I      intronic chr1:44162957(+) A-I      intronic chr1:44129588(+) A-I      intronic chr1:44168874(+) A-I      intronic chr1:44129566(+) A-I      intronic chr1:44127143(+) A-I      intronic chr1:44129579(+) A-I      intronic chr1:44124843(+) A-I      intronic chr1:44160096(+) A-I      intronic chr1:44144492(+) A-I      intronic chr1:44151318(+) A-I      intronic chr1:44122584(+) A-I      intronic chr1:44141702(+) A-I      intronic chr1:44125013(+) A-I      intronic chr1:44127212(+) A-I      intronic chr1:44142054(+) A-I      intronic chr1:44124710(+) A-I      intronic chr1:44126715(+) A-I      intronic chr1:44129412(+) A-I      intronic chr1:44152191(+) A-I      intronic chr1:44165029(+) A-I      intronic chr1:44137959(+) A-I      intronic chr1:44162999(+) A-I      intronic chr1:44140333(+) A-I      intronic chr1:44141873(+) A-I      intronic chr1:44142251(+) A-I      intronic chr1:44152282(+) A-I      intronic chr1:44129982(+) A-I      intronic chr1:44126867(+) A-I      intronic chr1:44142840(+) A-I      intronic chr1:44128228(+) A-I      intronic chr1:44129540(+) A-I      intronic chr1:44127585(+) A-I      intronic chr1:44123821(+) A-I      intronic chr1:44128182(+) A-I      intronic chr1:44141709(+) A-I      intronic chr1:44141906(+) A-I      intronic chr1:44129490(+) A-I      intronic chr1:44127589(+) A-I      intronic chr1:44129557(+) A-I      intronic chr1:44141834(+) A-I      intronic chr1:44144388(+) A-I      intronic chr1:44129567(+) A-I      intronic chr1:44129573(+) A-I      intronic chr1:44127166(+) A-I      intronic chr1:44141488(+) A-I      intronic chr1:44127024(+) A-I      intronic chr1:44142252(+) A-I      intronic chr1:44140329(+) A-I      intronic chr1:44139876(+) A-I      intronic chr1:44128114(+) A-I      intronic chr1:44127221(+) A-I      intronic chr1:44141903(+) A-I      intronic chr1:44138426(+) A-I      intronic chr1:44168820(+) A-I      intronic chr1:44168591(+) A-I      intronic chr1:44126775(+) A-I      intronic chr1:44168546(+) A-I      intronic chr1:44141832(+) A-I      intronic chr1:44141624(+) A-I      intronic chr1:44141489(+) A-I      intronic chr1:44136638(+) A-I      intronic chr1:44142755(+) A-I      intronic chr1:44127068(+) A-I      intronic chr1:44128258(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	KDM4A	chr1:44129557(+) A-I intron -    22327324 chr1:44129573(+) A-I intron -    22327324 chr1:44141709(+) A-I intron -    22327324 chr1:44123821(+) A-G intron -    22484847 chr1:44123853(+) A-G intron -    22484847 chr1:44123870(+) A-G intron -    22484847 chr1:44123880(+) A-G intron -    22484847 chr1:44126715(+) A-G intron -    22484847 chr1:44126914(+) A-G intron -    22484847 chr1:44127024(+) A-G intron -    22484847 chr1:44127030(+) A-G intron -    22484847 chr1:44127068(+) A-G intron -    22484847 chr1:44127143(+) A-G intron -    22484847 chr1:44127162(+) A-G intron -    22484847 chr1:44127166(+) A-G intron -    22484847 chr1:44127589(+) A-G intron -    22484847 chr1:44127614(+) A-G intron -    22484847 chr1:44127633(+) A-G intron -    22484847 chr1:44127635(+) A-G intron -    22484847 chr1:44127845(+) A-G intron -    22484847 chr1:44128159(+) A-G intron -    22484847 chr1:44128182(+) A-G intron -    22484847 chr1:44128228(+) A-G intron -    22484847 chr1:44129490(+) A-G intron -    22484847 chr1:44129540(+) A-G intron -    22484847 chr1:44129566(+) A-G intron -    22484847 chr1:44129573(+) A-G intron -    22484847 chr1:44129960(+) A-G intron -    22484847 chr1:44129982(+) A-G intron -    22484847 chr1:44136144(+) G-A intron -    22484847 chr1:44141709(+) A-G intron -    22484847 chr1:44141903(+) A-G intron -    22484847 chr1:44141915(+) T-C intron -    22484847 chr1:44141922(+) T-C intron -    22484847 chr1:44141939(+) T-C intron -    22484847 chr1:44141947(+) T-C intron -    22484847 chr1:44141953(+) A-G intron -    22484847 chr1:44142054(+) A-G intron -    22484847 chr1:44142060(+) T-C intron -    22484847 chr1:44142131(+) A-G intron -    22484847 chr1:44142133(+) A-G intron -    22484847 chr1:44142755(+) A-G intron -    22484847 chr1:44142762(+) A-G intron -    22484847 chr1:44142771(+) C-A intron -    22484847 chr1:44142896(+) A-G intron -    22484847 chr1:44147742(+) T-C intron -    22484847 chr1:44149982(+) T-C intron -    22484847 chr1:44149986(+) T-C intron -    22484847 chr1:44152191(+) A-G intron -    22484847 chr1:44152205(+) A-G intron -    22484847 chr1:44160043(+) T-C intron -    22484847 chr1:44160104(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KDM4A	chr1:44116209-44116210(+) m6A exon//intron       25456834//24981863 chr1:44133516-44133517(+) m6A CDS       24284625//24981863 chr1:44133536-44133537(+) m6A CDS       24284625//24981863 chr1:44133600-44133601(+) m6A CDS       24284625//24981863//27773535 chr1:44133644-44133645(+) m6A CDS       24284625//24981863//27773535 chr1:44133677-44133678(+) m6A CDS       24284625//24981863 chr1:44133685-44133686(+) m6A CDS       24284625//24981863 chr1:44134792-44134793(+) m6A CDS       24284625//24981863 chr1:44137390-44137391(+) m6A CDS       - chr1:44163618-44163619(+) m6A CDS       - chr1:44169779-44169780(+) m6A CDS       24981863 chr1:44169913-44169914(+) m6A CDS       24981863//27773535 chr1:44170109-44170110(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr1:44170335-44170336(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr1:44170361-44170362(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr1:44170490-44170491(+) m6A 3'UTR       24284625//24209618//22608085 chr1:44170633-44170634(+) m6A 3'UTR       24284625 chr1:44170644-44170645(+) m6A 3'UTR       24284625 chr1:44170717-44170718(+) m6A 3'UTR       24284625//24981863 chr1:44170908-44170909(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-130a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	KDM4A	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-130a-5p	Eloxatine 5310940 Drug interaction    RC00006934 5-Fluorouracil 3385 Drug interaction    RC00006933

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-130a-5p	Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-130a-5p
Interactor2: KDM4A

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).