Detail Information

Basic Information:


  VIRBase ID:  

HHID00011567

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           PTPRB:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p PTPRB
miRBase
Accession/Entrez ID		 MIMAT0004593 5787
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HPTP-BETA//HPTPB//PTPB//R-PTP-BETA//VEPTP

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PTPRB
chr12:70941438(-) A-I      intronic
chr12:70941525(-) A-I      intronic
chr12:70984875(-) A-I      intronic
chr12:70941529(-) A-I      intronic
chr12:70941944(-) A-I      intronic
chr12:70984839(-) A-I      intronic
chr12:70941464(-) A-I      intronic
chr12:70941941(-) A-I      intronic
chr12:70941514(-) A-I      intronic
chr12:71028321(-) A-I      intronic
chr12:70941460(-) A-I      intronic
chr12:70984843(-) A-I      intronic
chr12:70941425(-) A-I      intronic
chr12:70941304(-) A-I      intronic
chr12:70967466(-) A-I      intronic
chr12:70967469(-) A-I      intronic
chr12:70967475(-) A-I      intronic
chr12:70967488(-) A-I      intronic
chr12:70967514(-) A-I      intronic
chr12:70993622(-) A-I      intronic
chr12:70994620(-) A-I      intronic
chr12:70994710(-) A-I      intronic
chr12:70994785(-) A-I      intronic
chr12:70997969(-) A-I      intronic
chr12:70967446(-) A-I      intronic
chr12:70997975(-) A-I      intronic
chr12:70967424(-) A-I      intronic
chr12:70967284(-) A-I      intronic
chr12:70942026(-) A-I      intronic
chr12:70942025(-) A-I      intronic
chr12:70941986(-) A-I      intronic
chr12:70941980(-) A-I      intronic
chr12:70941466(-) A-I      intronic
chr12:70967450(-) A-I      intronic
chr12:70924553(-) A-I      intronic
chr12:70941483(-) A-I      intronic
chr12:70941904(-) A-I      intronic
chr12:70993690(-) A-I      intronic
chr12:70941480(-) A-I      intronic
chr12:70941505(-) A-I      intronic
chr12:70941389(-) A-I      intronic
chr12:70993667(-) A-I      intronic
chr12:70994604(-) A-I      intronic
chr12:70941559(-) A-I      intronic
chr12:70941431(-) A-I      intronic
chr12:70941885(-) A-I      intronic
chr12:70978740(-) A-I      intronic
chr12:70984835(-) A-I      intronic
chr12:70982611(-) A-I      intronic
chr12:70941844(-) A-I      intronic
chr12:70941566(-) A-I      intronic
chr12:70941927(-) A-I      intronic
chr12:70993664(-) A-I      intronic
chr12:70982621(-) A-I      intronic
chr12:70941384(-) A-I      intronic
chr12:70941481(-) A-I      intronic
chr12:70941560(-) A-I      intronic
chr12:70941503(-) A-I      intronic
chr12:70941999(-) A-I      intronic
chr12:70942000(-) A-I      intronic
chr12:70941411(-) A-I      intronic
chr12:70995034(-) A-I      intronic
chr12:71006563(-) A-I      intronic
chr12:70994573(-) A-I      intronic
chr12:70995709(-) A-I      intronic
chr12:70967379(-) A-I      intronic
chr12:70995676(-) A-I      intronic
chr12:70962988(-) A-I      intronic
chr12:70994568(-) A-I      intronic
chr12:71008022(-) A-I      intronic
chr12:70942022(-) A-I      intronic
chr12:70941506(-) A-I      intronic
chr12:70994578(-) A-I      intronic
chr12:70941850(-) A-I      intronic
chr12:70955793(-) A-I      intronic
chr12:70941468(-) A-I      intronic
chr12:70942021(-) A-I      intronic
chr12:70995055(-) A-I      intronic
chr12:70941424(-) A-I      intronic
chr12:70993637(-) A-I      intronic
chr12:70955806(-) A-I      intronic
chr12:70946021(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PTPRB
chr12:70963539-70963540(-) m6A 3'UTR//CDS       -
chr12:70963577-70963578(-) m6A 3'UTR//CDS       -
chr12:70963649-70963650(-) m6A 3'UTR//CDS       -
chr12:70963654-70963655(-) m6A 3'UTR//CDS       -
chr12:71002583-71002584(-) m6A 3'UTR//intron       25456834
chr12:71002641-71002642(-) m6A 3'UTR//intron       25456834
chr12:71002659-71002660(-) m6A 3'UTR//intron       25456834
chr12:71002669-71002670(-) m6A 3'UTR//intron       25456834
chr12:71029621-71029622(-) m6A CDS//exon//intron       -
chr12:71029647-71029648(-) m6A CDS//exon//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
PTPRB
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: PTPRB

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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