Detail Information

Basic Information:


  VIRBase ID:  

HHID00011502

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           HOXB4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p HOXB4
miRBase
Accession/Entrez ID		 MIMAT0004593 3214
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HOX-2.6//HOX2//HOX2F

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase HOXB4
chr17:46653297-46653298(-) m6A 3'UTR       24981863//28052920//27371828//22608085
chr17:46653305-46653306(-) m6A 3'UTR       24981863//28052920//27371828//22608085
chr17:46653573-46653574(-) m6A 3'UTR       28052920//22608085
chr17:46653791-46653792(-) m6A 3'UTR       27371828//22608085
chr17:46654011-46654012(-) m6A 3'UTR       22608085
chr17:46654058-46654059(-) m6A 3'UTR       28052920//27371828//22608085
chr17:46654180-46654181(-) m6A CDS       27371828//27773536
chr17:46654204-46654205(-) m6A CDS       27371828//27773536
chr17:46654340-46654341(-) m6A CDS       28052920
chr17:46654378-46654379(-) m6A CDS       28052920
chr17:46655307-46655308(-) m6A CDS       28052920//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
HOXB4
Exosome Blood     -
Nucleolus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: HOXB4

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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