Detail Information

Basic Information:


  VIRBase ID:  

HHID00011467

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           CHUK:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p CHUK
miRBase
Accession/Entrez ID		 MIMAT0004593 1147
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IKBKA//IKK-alpha//IKK1//IKKA//NFKBIKA//TCF16

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CHUK
chr10:101971736(-) A-I      intronic
chr10:101983246(-) A-I      intronic
chr10:101981559(-) A-I      intronic
chr10:101968034(-) A-I      intronic
chr10:101973070(-) A-I      intronic
chr10:101983283(-) A-I      intronic
chr10:101983208(-) A-I      intronic
chr10:101971816(-) A-I      intronic
chr10:101981583(-) A-I      intronic
chr10:101981688(-) A-I      intronic
chr10:101984771(-) A-I      intronic
chr10:101981594(-) A-I      intronic
chr10:101983247(-) A-I      intronic
chr10:101957550(-) A-I      intronic
chr10:101981588(-) A-I      intronic
chr10:101968043(-) A-I      intronic
chr10:101968481(-) A-I      intronic
chr10:101972994(-) A-I      intronic
chr10:101977510(-) A-I      intronic
chr10:101971807(-) A-I      intronic
chr10:101968041(-) A-I      intronic
chr10:101967925(-) A-I      intronic
chr10:101971732(-) A-I      intronic
chr10:101968535(-) A-I      intronic
chr10:101968010(-) A-I      intronic
chr10:101962678(-) A-I      intronic
chr10:101973093(-) A-I      intronic
chr10:101968302(-) A-I      intronic
chr10:101967961(-) A-I      intronic
chr10:101968410(-) A-I      intronic
chr10:101968394(-) A-I      intronic
chr10:101973072(-) A-I      intronic
chr10:101988351(-) A-I      intronic
chr10:101973521(-) A-I      intronic
chr10:101949650(-) A-I      intronic
chr10:101973035(-) A-I      intronic
chr10:101968480(-) A-I      intronic
chr10:101968135(-) A-I      intronic
chr10:101965515(-) A-I      intronic
chr10:101971737(-) A-I      intronic
chr10:101988378(-) A-I      intronic
chr10:101973458(-) A-I      intronic
chr10:101973119(-) A-I      intronic
chr10:101967966(-) A-I      intronic
chr10:101967892(-) A-I      intronic
chr10:101973472(-) A-I      intronic
chr10:101973482(-) A-I      intronic
chr10:101968378(-) A-I      intronic
chr10:101973417(-) A-I      intronic
chr10:101956233(-) A-I      intronic
chr10:101968114(-) A-I      intronic
chr10:101973066(-) A-I      intronic
chr10:101988404(-) A-I      intronic
chr10:101988166(-) A-I      intronic
chr10:101968136(-) A-I      intronic
chr10:101971804(-) A-I      intronic
chr10:101988167(-) A-I      intronic
chr10:101981533(-) A-I      intronic
chr10:101976384(-) A-I      intronic
chr10:101971810(-) A-I      intronic
chr10:101957562(-) A-I      intronic
chr10:101973411(-) A-I      intronic
chr10:101968393(-) A-I      intronic
chr10:101973012(-) A-I      intronic
chr10:101968118(-) A-I      intronic
chr10:101973180(-) A-I      intronic
chr10:101968028(-) A-I      intronic
chr10:101972596(-) A-I      intronic
chr10:101973346(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CHUK
chr10:101968481(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CHUK
chr10:101985771-101985772(-) m6A CDS       24209618//27371828//27773536
chr10:101989315-101989316(-) m6A 5'UTR       24981863//27371828//27773536
chr10:101989326-101989327(-) m6A 5'UTR       24981863//27371828//27773536
chr10:101989338-101989339(-) m6A 5'UTR       24981863//27371828//27773536
chr10:101989368-101989369(-) m6A 5'UTR       24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
CHUK
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: CHUK

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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