Basic Information:

  VIRBase ID:  

HHID00011442

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:  MIMAT0004593          AQP9:  NM_001320636     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-130a-5p	AQP9
miRBase Accession/Entrez ID	MIMAT0004593	366
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AQP-9//HsT17287//SSC1//T17287

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-130a-5p	rs746985078 chr11:57641223    A/G rs779670380 chr11:57641222    C/T rs758215186 chr11:57641219    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	AQP9	chr15:58468592(+) A-I      intronic chr15:58468605(+) A-I      intronic chr15:58468541(+) A-I      intronic chr15:58468539(+) A-I      intronic chr15:58468990(+) A-I      intronic chr15:58468903(+) A-I      intronic chr15:58468943(+) A-I      intronic chr15:58468602(+) A-I      intronic chr15:58468631(+) A-I      intronic chr15:58468909(+) A-I      intronic chr15:58469007(+) A-I      intronic chr15:58468910(+) A-I      intronic chr15:58468997(+) A-I      intronic chr15:58468642(+) A-I      intronic chr15:58468556(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	AQP9	chr15:58430549-58430550(+) m6A 5'UTR//exon//intron       - chr15:58430563-58430564(+) m6A 5'UTR//exon//intron       - chr15:58476280-58476281(+) m6A CDS       - chr15:58476285-58476286(+) m6A CDS       - chr15:58476296-58476297(+) m6A CDS       - chr15:58476315-58476316(+) m6A CDS       - chr15:58476458-58476459(+) m6A 3'UTR       - chr15:58476496-58476497(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-130a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	AQP9	Exosome Blood     - Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-130a-5p	Eloxatine 5310940 Drug interaction    RC00006934 5-Fluorouracil 3385 Drug interaction    RC00006933

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-130a-5p	Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-130a-5p
Interactor2: AQP9

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).