Detail Information

Basic Information:


  VIRBase ID:  

HHID00011438

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           ADRA2A:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p ADRA2A
miRBase
Accession/Entrez ID		 MIMAT0004593 150
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ADRA2//ADRA2R//ADRAR//ALPHA2AAR//ZNF32

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ADRA2A
chr10:112837185-112837186(+) m6A 5'UTR       25456834
chr10:112837245-112837246(+) m6A 5'UTR       25456834
chr10:112837252-112837253(+) m6A 5'UTR       25456834
chr10:112837320-112837321(+) m6A 5'UTR       25456834
chr10:112837582-112837583(+) m6A 5'UTR       25456834
chr10:112837691-112837692(+) m6A 5'UTR       25456834
chr10:112837844-112837845(+) m6A CDS       25456834
chr10:112839063-112839064(+) m6A CDS       25456834
chr10:112839132-112839133(+) m6A CDS       25456834
chr10:112839175-112839176(+) m6A 3'UTR       25456834
chr10:112839237-112839238(+) m6A 3'UTR       25456834
chr10:112839486-112839487(+) m6A 3'UTR       25456834
chr10:112840367-112840368(+) m6A 3'UTR       25456834//24981863
chr10:112840396-112840397(+) m6A 3'UTR       25456834//24981863
chr10:112840432-112840433(+) m6A 3'UTR       25456834//24981863
chr10:112840438-112840439(+) m6A 3'UTR       25456834//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
ADRA2A
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: ADRA2A

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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