Detail Information

Basic Information:


  VIRBase ID:  

HHID00011436

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           ACTN2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p ACTN2
miRBase
Accession/Entrez ID		 MIMAT0004593 88
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CMD1AA//CMH23//MPD6//MYOCOZ

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ACTN2
chr1:236892518(+) A-I      intronic
chr1:236892536(+) A-I      intronic
chr1:236892526(+) A-I      intronic
chr1:236892535(+) A-I      intronic
chr1:236892530(+) A-I      intronic
chr1:236892504(+) A-I      intronic
chr1:236892494(+) A-I      intronic
chr1:236888879(+) A-I      intronic
chr1:236891583(+) A-I      intronic
chr1:236860608(+) A-I      intronic
chr1:236854424(+) A-I      intronic
chr1:236879135(+) A-I      intronic
chr1:236854409(+) A-I      intronic
chr1:236888772(+) A-I      intronic
chr1:236859603(+) A-I      intronic
chr1:236860532(+) A-I      intronic
chr1:236886905(+) A-I      intronic
chr1:236854342(+) A-I      intronic
chr1:236892154(+) A-I      intronic
chr1:236860131(+) A-I      intronic
chr1:236886932(+) A-I      intronic
chr1:236854449(+) A-I      intronic
chr1:236860581(+) A-I      intronic
chr1:236886949(+) A-I      intronic
chr1:236885681(+) A-I      intronic
chr1:236892417(+) A-I      intronic
chr1:236886931(+) A-I      intronic
chr1:236884457(+) A-I      intronic
chr1:236858162(+) A-I      intronic
chr1:236859496(+) A-I      intronic
chr1:236860470(+) A-I      intronic
chr1:236886996(+) A-I      intronic
chr1:236885856(+) A-I      intronic
chr1:236885855(+) A-I      intronic
chr1:236860515(+) A-I      intronic
chr1:236886995(+) A-I      intronic
chr1:236886908(+) A-I      intronic
chr1:236858220(+) A-I      intronic
chr1:236858457(+) A-I      intronic
chr1:236860546(+) A-I      intronic
chr1:236886830(+) A-I      intronic
chr1:236880193(+) A-I      intronic
chr1:236886883(+) A-I      intronic
chr1:236858183(+) A-I      intronic
chr1:236886895(+) A-I      intronic
chr1:236892413(+) A-I      intronic
chr1:236859487(+) A-I      intronic
chr1:236888659(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ACTN2
chr1:236914937-236914938(+) m6A CDS       -
chr1:236914947-236914948(+) m6A CDS       -
chr1:236917202-236917203(+) m6A exon//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
ACTN2
Chromatin K562 cells     -
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: ACTN2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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