Basic Information:

  VIRBase ID:  

HHID00011430

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          TMPRSS11BNL:  NR_104048     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	TMPRSS11BNL
miRBase Accession/Entrez ID	MIMAT0004588	401136
Organism	Homo sapiens	Homo sapiens
Category	miRNA	pseudo
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	TMPRSS11BNL	2-(((5-(4-(4-(3-Fluorobenzyloxy)-3-chlorophenylamino)quinazolin-6-yl)furan-2-yl)methyl)(2-(methylsulfonyl)ethyl)amino)acetonitrile       9873849 9H-Purine, 6-(ethylthio)-9-beta-D-ribofuranosyl-(8CI)(9CI)       95846 6-Benzylthioinosine       95263 Tiotixene       941651 Pentamidine isethionate       8813 Acridine Yellow G       8672 Sulfonaphtholazoresorcinol       85517 Benzethonium chloride       8478 3-Amino-7-(dimethylamino)-5-phenylphenazinium chloride       75442 5-Methyl-1,10-phenanthroline       72791 Hydrastinine Hydrochloride       71833 1-(2-Pyridylazo)-2-naphthol       6825 3-Hydroxy-3'-nitro-2-naphthanilide       67277 Tanespimycin       6505803 Phylanthoside       6436218 4-(N-Hydroxyacetamido)stilbene       6433723 3-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol;hydrochloride       57399804 5-[2-[4-(Aminomethyl)phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl]-2-chlorophenol;hydrochloride       57399803 Methyl N-[6-[3-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]carbamate;hydrochloride       57399798 Ethyl red       54832 Phyllanthastatin 1       5477587 Fumagillin dicyclohexylamine salt       5474187 11-Cyanomethylen-11H-indolo[1,2-a]indazole       5472501 Mito-tempol       54613387 Curromycin A.B mixture       54608021 Herveline O       5459269 (10R,13R,16R,19S)-16-Butan-2-yl-3-(3-chloro-2-hydroxypropyl)-10,11,14-trimethyl-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone       5459202 1-[2-[p-[alpha-(p-Methoxyphenyl)-beta-nitrostyryl]phenoxy]ethyl]pyrrolidine citrate (1:1)       5381092 Zimeldine       5365247 Rubremetinium chloride       5351504 Purapuridine       5250 Alsterpaullone       5005498 Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine       498558 Pentamidine       4735 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one       4713 Okadaic acid       446512 4-[1-(4-Aminomethyl-phenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine       44397453 Ouabain       439501 6,15-Dihydroxy-18-(1-hydroxyethyl)-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione       430232 Vemurafenib       42611257 1,6-Bis[4-(4-aminophenoxy)phenyl]diamantane       397904 7-Epi-3,4-bis-nor-dolastatin 11       396354 Ptilomycalin A format salt       395755 Trihydroxy-azatoxin       381591 Diisopropoxybis(1,4-naphthochinone-2-olato)titanium(IV)       368058 Paclitaxel       36314 1,2,4,5-Tetrazine, 3,6-bis(1-azetidinyl)-       362170 3,4-Dihydroxynaphthalene-2-carboxylic acid       356138 2,3-Dimethylbenzo[g]quinoxaline-5,10-dione       353644 (3-Phenoxypropyl)triphenylphosphonium bromide       3048782 Clomifene citrate       3033832 AT 116, benzylamine salt       282523 10-(6'-Ubiquinolyl)decyltriphenylphosphonium       24783759 (2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide       24200489 Arenaemycin E       24199350 1-Dodecyl-4-nonylpyridinium chloride       24180869 2-Chloro-3-[(furan-2-ylmethyl)amino]naphthalene-1,4-dione       239677 Aristolochic acid       2236 6-Chloro-2-methoxy-9-[(5-piperidinopentyl)amino]acridine       219600 Nutlin-3       216345 8-Amino-5-methyl-6-phenylphenanthridin-5-ium bromide       21144180 Kinetin riboside       20345 Erlotinib       176870 Mercury, (acetyloxy)(pentamethylphenyl)-       16683786 N-[5-[5-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-pyridin-4-ylfuran-3-yl]-2,3-dihydroinden-1-ylidene]hydroxylamine;hydrochloride       136207967 Astrazon Orange R       135747272 N,N-Dimethyl-2-[4-[4-(1-nitroso-2,3-dihydroinden-5-ylidene)-5-(1H-pyridin-4-ylidene)-1H-imidazol-2-yl]phenoxy]ethanamine       135564599 Dovitinib       135398510 Berberine chloride       12456 (Z)-But-2-enedioic acid;3-[4-[(3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]-N-methylpropanamide       11954261 Bafetinib       11387605 Pararosaniline hydrochloride       11292 Setoglaucine       107404 [(4-Methylphenyl)methyl](triphenyl)arsanium bromide       10672721 Dequalinium chloride       10649 Pha-665752       10461815 25-Dihydrosaframycin A       100180 1,4-benzenediamine (9ci), n-butyl-n'-phenyl-       - ;2-(3-((2-methoxybenzyl)amino)propyl)-7-(3-((4-((3-(meth...       - ;4-fluoro-N-(3-(4-(6-(4-hydroxyphenyl)imidazo[2,1-b]thia...       - 5,6-ethylenediquino[3,2-b       - ;9-benzyl-7-benzyloxy-2-benzyl-1-methyl-9H-carbolinium b...       - antibiotic 2-79-a(5)       - benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 3-methyl-       - benzo[b]naphtho[2,3-d]furan-6,11-dione, 4-chloro-3-hydroxy       - [co(me2dtc)2(dee)]clo4       - crotoxin cd       - gamitrinib-g4       - gramicidin       - g-tpp       - Hypothemycin       - indoline, 5-chloro-1,3,3-trimethyl-2-methylene- (8ci)       - methylbenzethonium chloride (usan)       - naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)-       - naphtho[2,1-b]quinolizinium, 5-chloro-7-methyl- perchlorate       - naphtho[2,3-b]furan-4,9-dione, 2-bromo-       - N-methyl-N-(4-(3-(pyrrolidin-1-yl)propoxy)benzyl)-4-(2,6...       - protein toxin a 23 - mw approx. 6700       - protein toxin b 15 - mw approx 6700       - protein toxin c 10 - mw approx. 6700       - protein toxin d 5 - mw approx 6700       - rhodium dimer       - riboprine(usan)       - tp38-279       - tp4ek-k6       - tp4ek       - Tyrothricin       -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: TMPRSS11BNL

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).