Detail Information

Basic Information:


  VIRBase ID:  

HHID00011424

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p PALM2
miRBase
Accession/Entrez ID		 MIMAT0004588 PALM2
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PALM2
chr4:57568238-57568239(+) m6A 5'UTR//intron       25569111
chr4:57637861-57637862(+) m6A intron       24981863
chr4:57638062-57638063(+) m6A CDS//exon       25412662//24981863//25569111
chr4:57648037-57648038(+) m6A CDS//exon       25412662//24981863//25569111
chr4:57688490-57688491(+) m6A CDS//exon       24981863//25412662//25569111
chr4:57688519-57688520(+) m6A CDS//exon       24981863//25569111
chr4:57709483-57709484(+) m6A 3'UTR//CDS//exon       24981863//25569111
chr4:57709491-57709492(+) m6A 3'UTR//CDS       24981863//25569111
chr4:57709500-57709501(+) m6A 3'UTR//CDS       24981863//25569111
chr4:57709676-57709677(+) m6A 3'UTR//CDS       25683224//25412662//24981863//25456834//25569111//22608085
chr4:57709694-57709695(+) m6A 3'UTR//CDS       25683224//25412662//24981863//25456834//25569111//22608085
chr4:57709710-57709711(+) m6A 3'UTR//CDS       25683224//25412662//24981863//25456834//25569111//22608085
chr4:57709748-57709749(+) m6A 3'UTR//CDS       25683224//25412662//24981863//25456834//25569111//22608085
chr4:57709816-57709817(+) m6A 3'UTR//CDS       25683224//25412662//24981863//25569111
chr4:57709864-57709865(+) m6A 3'UTR//CDS       25683224//25412662//24981863//25569111
chr4:57709906-57709907(+) m6A 3'UTR//CDS       25412662//24981863//25569111
chr4:57709926-57709927(+) m6A 3'UTR//CDS       25412662//24981863//25569111
chr4:57709953-57709954(+) m6A 3'UTR//CDS       25412662//24981863//25569111
chr4:57710013-57710014(+) m6A 3'UTR//CDS       25683224//25412662//24981863//25569111//22608085
chr4:57710080-57710081(+) m6A 3'UTR//CDS       25412662//24981863//25569111//22608085
chr4:57710090-57710091(+) m6A 3'UTR//CDS       25412662//24981863//25569111//22608085
chr4:57710131-57710132(+) m6A 3'UTR//CDS       25456834//25412662//24981863//25569111//22608085
chr4:57710247-57710248(+) m6A 3'UTR       25456834//24981863//25569111//22608085
chr4:57710279-57710280(+) m6A 3'UTR       25456834//24981863//25569111//22608085
chr4:57710290-57710291(+) m6A 3'UTR       25456834//24981863//25569111//22608085
chr4:57710362-57710363(+) m6A 3'UTR       25456834//24981863//25569111//22608085
chr4:57710402-57710403(+) m6A 3'UTR       25456834//24981863//25569111//22608085
chr4:57710420-57710421(+) m6A 3'UTR       25456834//24981863//25569111//22608085
chr4:57710476-57710477(+) m6A 3'UTR       25683224//25456834//24981863//25569111//22608085
chr4:57710524-57710525(+) m6A 3'UTR       25683224//25456834//24981863//25569111//22608085
chr4:57710580-57710581(+) m6A 3'UTR       25456834//24981863//25569111//22608085
chr4:57710592-57710593(+) m6A 3'UTR       25456834//24981863//25569111//22608085
chr4:57710752-57710753(+) m6A 3'UTR       24981863//25569111
chr4:57710846-57710847(+) m6A 3'UTR       24981863
chr4:57710874-57710875(+) m6A 3'UTR       24981863
chr4:57710905-57710906(+) m6A 3'UTR       24981863
chr4:57710960-57710961(+) m6A 3'UTR       24981863
chr4:57710985-57710986(+) m6A 3'UTR       24981863
chr9:112705191-112705192(+) m6A CDS       24284625//24209618//24981863//22608085
chr9:112705197-112705198(+) Am CDS       -
chr9:112705228-112705229(+) m6A CDS       24284625//24209618//24981863//22608085
chr9:112705266-112705267(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr9:112705319-112705320(+) m6A CDS       24284625//24209618//24981863//22608085
chr9:112705334-112705335(+) m6A CDS       24284625//24209618//24981863//22608085
chr9:112705382-112705383(+) m6A CDS       24284625//24209618//24981863
chr9:112705471-112705472(+) m6A CDS       24284625//24209618
chr9:112705531-112705532(+) m6A CDS       24284625//24209618
chr9:112705598-112705599(+) m6A CDS       24284625//24209618
chr9:112705761-112705762(+) m6A 3'UTR       24284625
chr9:112705793-112705794(+) m6A 3'UTR       24284625
chr9:112705804-112705805(+) m6A 3'UTR       24284625
chr9:112705874-112705875(+) m6A 3'UTR       24284625
chr9:112705909-112705910(+) m6A 3'UTR       24284625
chr9:112705926-112705927(+) m6A 3'UTR       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: PALM2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

Starting a new search, please wait ...