Detail Information

Basic Information:


  VIRBase ID:  

HHID00011422

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p AP003774.4
miRBase
Accession/Entrez ID		 MIMAT0004588 AP003774.4
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase AP003774.4
chr11:64216654-64216655(+) m6A exon       -
chr11:64216688-64216689(+) m6A exon       22608085
chr11:64216728-64216729(+) m6A exon       22608085
chr11:64216802-64216803(+) m6A exon       25456834
chr11:64216933-64216934(+) m6A exon       22608085
chr11:64217385-64217386(+) m6A exon       -
chr11:64217535-64217536(+) m6A exon       25456834
chr11:64217540-64217541(+) m6A exon       25456834
chr11:64217591-64217592(+) m6A exon       25456834
chr11:64217884-64217885(+) m6A exon       -
chr11:64217897-64217898(+) m6A exon       -
chr11:64217908-64217909(+) m6A exon       -
chr11:64217915-64217916(+) m6A exon       -
chr11:64217975-64217976(+) m6A exon       -
chr11:64217999-64218000(+) m6A exon       -
chr11:64218010-64218011(+) m6A exon       -
chr11:64218023-64218024(+) m6A exon       -
chr11:64218720-64218721(+) m6A exon       -
chr11:64218760-64218761(+) m6A exon       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: AP003774.4

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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