Detail Information

Basic Information:


  VIRBase ID:  

HHID00011421

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p AL590822.2
miRBase
Accession/Entrez ID		 MIMAT0004588 AL590822.2
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase AL590822.2
chr1:2121340-2121341(+) m6A 5'UTR       -
chr1:2121381-2121382(+) m6A 5'UTR       -
chr1:2121635-2121636(+) m6A CDS       27773536
chr1:2121696-2121697(+) m6A CDS       27773536
chr1:2121842-2121843(+) m6A CDS       27773536
chr1:2122011-2122012(+) m6A CDS       24284625//25456834//22575960//22608085
chr1:2122115-2122116(+) m6A 3'UTR       24209618//25456834//24981863//27371828//22575960//22608085
chr1:2122195-2122196(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22608085
chr1:2122227-2122228(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22608085
chr1:2122293-2122294(+) m6A 3'UTR       24284625//25456834//24981863//27371828//22608085
chr1:2122400-2122401(+) m6A 3'UTR       24284625//25456834//27371828//27773536//22608085
chr1:2122411-2122412(+) m6A 3'UTR       24284625//25456834//27371828//27773536//22608085
chr1:2122514-2122515(+) m6A 3'UTR       25456834//27773536//22608085
chr1:2122541-2122542(+) m6A 3'UTR       25456834//27773536//22608085
chr1:2122598-2122599(+) m6A 3'UTR       25456834//27773536//22608085
chr1:2122668-2122669(+) m6A 3'UTR       27773536
chr1:2122760-2122761(+) m6A 3'UTR       27773536
chr1:2122781-2122782(+) m6A 3'UTR       27773536
chr1:2122984-2122985(+) m6A 3'UTR       24209618
chr1:2123007-2123008(+) m6A 3'UTR       24209618

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: AL590822.2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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