Detail Information

Basic Information:


  VIRBase ID:  

HHID00011414

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p AC073610.5
miRBase
Accession/Entrez ID		 MIMAT0004588 AC073610.5
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase AC073610.5
chr12:49315745-49315746(-) m6A 3'UTR       24981863//27773535
chr12:49315785-49315786(-) m6A 3'UTR       24981863//27773535
chr12:49315826-49315827(-) m6A 3'UTR       24981863//27773535
chr12:49316204-49316205(-) m6A intron       24284625//24981863
chr12:49316216-49316217(-) m6A intron       24284625//24981863
chr12:49316576-49316577(-) m6A intron       27773535
chr12:49316587-49316588(-) m6A intron       27773535
chr12:49317041-49317042(-) m6A intron       24981863//27773535
chr12:49317133-49317134(-) m6A intron       24284625//24981863//27773535
chr12:49317138-49317139(-) m6A intron       24284625//24981863//27773535
chr12:49317171-49317172(-) m6A intron       24284625//24981863//27773535//22608085
chr12:49317261-49317262(-) m6A intron       24284625//25456834//24981863//27773535//22608085
chr12:49317268-49317269(-) m6A intron       24284625//25456834//24981863//27773535//22608085
chr12:49317318-49317319(-) m6A intron       24284625//25456834//24981863//27773535//22608085
chr12:49317377-49317378(-) m6A intron       24284625//25456834//24981863//27773535//22608085
chr12:49317384-49317385(-) m6A intron       24284625//25456834//24981863//27773535
chr12:49318384-49318385(-) m6A intron       27773535
chr12:49318850-49318851(-) m6A intron       27371828
chr12:49318879-49318880(-) m6A intron       27371828
chr12:49318976-49318977(-) m6A intron       27371828
chr12:49319087-49319088(-) m6A intron       27371828
chr12:49319102-49319103(-) m6A intron       27371828
chr12:49319120-49319121(-) m6A intron       27371828
chr12:49319253-49319254(-) m6A intron       25456834//24981863//27371828//27773536
chr12:49319365-49319366(-) m6A intron       24284625//25456834//24981863
chr12:49319433-49319434(-) m6A intron       24284625//24209618//25456834//24981863//27773535//22608085
chr12:49319459-49319460(-) m6A intron       24284625//24209618//25456834//24981863//27773535//22608085
chr12:49319527-49319528(-) m6A intron       24284625//24209618//25456834//24981863//27773535//22608085
chr12:49319568-49319569(-) m6A intron       24284625//24209618//25456834//24981863//27773535//22608085
chr12:49319667-49319668(-) m6A intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr12:49319687-49319688(-) m6A intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr12:49319725-49319726(-) m6A intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr12:49319752-49319753(-) m6A intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr12:49319838-49319839(-) m6A intron       24284625//24981863//27773535//22608085
chr12:49319849-49319850(-) m6A intron       24284625//24981863//27773535//22608085
chr12:49331766-49331767(-) m6A intron       -
chr12:49332494-49332495(-) m6A intron       27773535
chr12:49332721-49332722(-) m6A intron       24284625//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr12:49332739-49332740(-) m6A CDS       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr12:49332763-49332764(-) m6A CDS       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr12:49332853-49332854(-) m6A CDS       24284625//24981863//26404942//27371828//22575960//22608085
chr12:49333440-49333441(-) m6A CDS       24284625//24981863
chr12:49333444-49333445(-) m6A CDS       26404942//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: AC073610.5

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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