Detail Information

Basic Information:


  VIRBase ID:  

HHID00011410

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p AC004076.7
miRBase
Accession/Entrez ID		 MIMAT0004588 AC004076.7
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase AC004076.7
chr19:57909916-57909917(+) m6A intron       24284625//24981863//22608085
chr19:57909938-57909939(+) m6A intron       24284625//24981863//22608085
chr19:57910082-57910083(+) m6A intron       24284625//24209618//25456834//24981863//22575960//22608085
chr19:57910136-57910137(+) m6A intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr19:57910202-57910203(+) m6A intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr19:57910211-57910212(+) m6A intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr19:57910228-57910229(+) m6A intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr19:57910233-57910234(+) m6A intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr19:57910267-57910268(+) m6A intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr19:57910380-57910381(+) m6A intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr19:57910387-57910388(+) m6A intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr19:57910408-57910409(+) m6A intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr19:57910464-57910465(+) m6A intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr19:57910548-57910549(+) m6A intron       24284625//24981863//27773535//22608085
chr19:57910613-57910614(+) m6A intron       24284625//24981863//27773535//22608085
chr19:57910632-57910633(+) m6A intron       24284625//24981863//27773535//22608085
chr19:57910659-57910660(+) m6A intron       24284625//24981863//22608085
chr19:57910716-57910717(+) m6A intron       22608085
chr19:57910800-57910801(+) m6A intron       22608085
chr19:57910884-57910885(+) m6A intron       -
chr19:57910968-57910969(+) m6A intron       22608085
chr19:57911079-57911080(+) m6A intron       24981863//22608085
chr19:57911203-57911204(+) m6A intron       24981863//22608085
chr19:57911219-57911220(+) m6A intron       24981863//22608085
chr19:57911318-57911319(+) m6A intron       24981863//22608085
chr19:57922417-57922418(+) m6A intron       22608085
chr19:57922434-57922435(+) m6A intron       22608085
chr19:57922446-57922447(+) m6A intron       22608085
chr19:57931121-57931122(+) m6A intron       24284625//24981863//22608085
chr19:57931143-57931144(+) m6A intron       24284625//24981863//22575960//22608085
chr19:57931172-57931173(+) m6A intron       24284625//24209618//24981863//22575960//22608085
chr19:57931296-57931297(+) m6A intron       24284625//24209618//25456834//24981863//22575960//22608085
chr19:57931386-57931387(+) m6A intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr19:57931417-57931418(+) m6A intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr19:57931452-57931453(+) m6A intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr19:57931564-57931565(+) m6A intron       24284625//24981863//22575960//22608085
chr19:57931900-57931901(+) m6A intron       24284625//24981863//22575960//22608085
chr19:57931965-57931966(+) m6A intron       24284625//24981863//22575960//22608085
chr19:57932011-57932012(+) m6A intron       24284625//22608085
chr19:57932068-57932069(+) m6A intron       24284625//22608085
chr19:57932133-57932134(+) m6A intron       22608085
chr19:57932236-57932237(+) m6A intron       24284625//25456834//24981863//22608085
chr19:57932301-57932302(+) m6A intron       24284625//24209618//25456834//24981863//22608085
chr19:57932347-57932348(+) m6A intron       24284625//24209618//25456834//24981863//22608085
chr19:57932488-57932489(+) m6A intron       24284625//22608085
chr19:57932600-57932601(+) m6A intron       24284625//25456834//24981863//22608085
chr19:57932637-57932638(+) m6A intron       24284625//24981863//22608085
chr19:57932740-57932741(+) m6A intron       24284625//24981863//22608085
chr19:57932767-57932768(+) m6A intron       24284625//24981863//27773535//22608085
chr19:57932879-57932880(+) m6A intron       24284625//24981863//22608085
chr19:57932915-57932916(+) m6A intron       24284625//24981863//22608085
chr19:57933057-57933058(+) m6A intron       24981863//22608085
chr19:57933078-57933079(+) m6A intron       24981863
chr19:57933160-57933161(+) m6A intron       24981863
chr19:57946780-57946781(+) m6A intron       25456834//24981863
chr19:57946927-57946928(+) m6A intron       -
chr19:57946950-57946951(+) m6A intron       -
chr19:57949673-57949674(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: AC004076.7

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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