Detail Information

Basic Information:


  VIRBase ID:  

HHID00011408

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           FAM47E-STBD1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p FAM47E-STBD1
miRBase
Accession/Entrez ID		 MIMAT0004588 100631383
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - FAM47E

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase FAM47E-STBD1
chr4:77211124-77211125(+) m6A CDS//intron       -
chr4:77227547-77227548(+) m1A intron       26863196
chr4:77227615-77227616(+) m6A intron       24981863
chr4:77227673-77227674(+) m6A intron       24981863
chr4:77227688-77227689(+) m6A intron       24981863
chr4:77227820-77227821(+) m6A intron       24981863
chr4:77228098-77228099(+) m6A intron       24284625//24209618//25456834//24981863//22608085
chr4:77228110-77228111(+) m6A intron       24284625//24209618//25456834//24981863//22608085
chr4:77228137-77228138(+) m6A intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr4:77230318-77230319(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr4:77230334-77230335(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr4:77230341-77230342(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr4:77230351-77230352(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr4:77230414-77230415(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr4:77230429-77230430(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr4:77230440-77230441(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr4:77230466-77230467(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr4:77230549-77230550(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr4:77230617-77230618(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr4:77230653-77230654(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr4:77230662-77230663(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr4:77230755-77230756(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr4:77230761-77230762(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr4:77230773-77230774(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr4:77230783-77230784(+) m1A 3'UTR       26863196
chr4:77230932-77230933(+) m6A 3'UTR       24209618//27773535//22608085
chr4:77230956-77230957(+) m6A 3'UTR       24209618//27773535//22608085
chr4:77231105-77231106(+) m6A 3'UTR       24981863//27773535
chr4:77231185-77231186(+) m6A 3'UTR       24981863
chr4:77231213-77231214(+) m6A 3'UTR       24981863
chr4:77231970-77231971(+) m6A 3'UTR       24981863
chr4:77232043-77232044(+) m6A 3'UTR       24981863
chr4:77232095-77232096(+) m6A 3'UTR       24284625//24981863
chr4:77232182-77232183(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
FAM47E-STBD1
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: FAM47E-STBD1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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