Basic Information:

  VIRBase ID:  

HHID00011407

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          TVP23C-CDRT4:  NM_001204478     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	TVP23C-CDRT4
miRBase Accession/Entrez ID	MIMAT0004588	100533496
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FAM18B2//FAM18B2-CDRT4//TVP23C

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TVP23C-CDRT4	chr17:15406531(-) A-I      NonSyn:Ile->Val chr17:15433316(-) A-I      intronic chr17:15434230(-) A-I      intronic chr17:15434205(-) A-I      intronic chr17:15434189(-) A-I      intronic chr17:15406595(-) A-I      ncRNA chr17:15413734(-) A-I      intronic chr17:15434251(-) A-I      intronic chr17:15434250(-) A-I      intronic chr17:15421236(-) A-I      intronic chr17:15421262(-) A-I      intronic chr17:15421297(-) A-I      intronic chr17:15421358(-) A-I      intronic chr17:15421374(-) A-I      intronic chr17:15421444(-) A-I      intronic chr17:15452876(-) A-I      intronic chr17:15464008(-) A-I      intronic chr17:15464141(-) A-I      intronic chr17:15426806(-) A-I      intronic chr17:15432600(-) A-I      intronic chr17:15432617(-) A-I      intronic chr17:15432684(-) A-I      intronic chr17:15433137(-) A-I      intronic chr17:15433210(-) A-I      intronic chr17:15433251(-) A-I      intronic chr17:15433257(-) A-I      intronic chr17:15433277(-) A-I      intronic chr17:15433306(-) A-I      intronic chr17:15434224(-) A-I      intronic chr17:15434232(-) A-I      intronic chr17:15432594(-) A-I      intronic chr17:15432586(-) A-I      intronic chr17:15432583(-) A-I      intronic chr17:15434329(-) A-I      intronic chr17:15424816(-) A-I      intronic chr17:15426189(-) A-I      intronic chr17:15426493(-) A-I      intronic chr17:15426518(-) A-I      intronic chr17:15426710(-) A-I      intronic chr17:15426740(-) A-I      intronic chr17:15426753(-) A-I      intronic chr17:15407934(-) A-I      intronic chr17:15432561(-) A-I      intronic chr17:15432563(-) A-I      intronic chr17:15423153(-) A-I      intronic chr17:15424597(-) A-I      intronic chr17:15424653(-) A-I      intronic chr17:15424700(-) A-I      intronic chr17:15421420(-) A-I      intronic chr17:15421400(-) A-I      intronic chr17:15421238(-) A-I      intronic chr17:15411090(-) A-I      intronic chr17:15423107(-) A-I      intronic chr17:15423116(-) A-I      intronic chr17:15438039(-) A-I      intronic chr17:15410988(-) A-I      intronic chr17:15438160(-) A-I      intronic chr17:15438165(-) A-I      intronic chr17:15410896(-) A-I      intronic chr17:15438170(-) A-I      intronic chr17:15439254(-) A-I      intronic chr17:15439395(-) A-I      intronic chr17:15445929(-) A-I      intronic chr17:15423094(-) A-I      intronic chr17:15422981(-) A-I      intronic chr17:15422742(-) A-I      intronic chr17:15434237(-) A-I      intronic chr17:15434235(-) A-I      intronic chr17:15452874(-) A-I      intronic chr17:15431987(-) A-I      intronic chr17:15432207(-) A-I      intronic chr17:15426850(-) A-I      intronic chr17:15426895(-) A-I      intronic chr17:15426988(-) A-I      intronic chr17:15427025(-) A-I      intronic chr17:15427099(-) A-I      intronic chr17:15427133(-) A-I      intronic chr17:15424736(-) A-I      intronic chr17:15407939(-) A-I      intronic chr17:15427199(-) A-I      intronic chr17:15441711(-) A-I      3'UTR chr17:15441835(-) A-I      3'UTR chr17:15441866(-) A-I      3'UTR chr17:15406610(-) A-I      ncRNA chr17:15442677(-) A-I      3'UTR chr17:15441737(-) A-I      3'UTR chr17:15441686(-) A-I      3'UTR chr17:15441740(-) A-I      3'UTR chr17:15441746(-) A-I      3'UTR chr17:15406498(-) A-I      NonSyn:Arg->Gly chr17:15441755(-) A-I      3'UTR chr17:15433292(-) A-I      intronic chr17:15408131(-) A-I      intronic chr17:15421284(-) A-I      intronic chr17:15432680(-) A-I      intronic chr17:15421373(-) A-I      intronic chr17:15424574(-) A-I      intronic chr17:15421224(-) A-I      intronic chr17:15434168(-) A-I      intronic chr17:15424706(-) A-I      intronic chr17:15426872(-) A-I      intronic chr17:15411041(-) A-I      intronic chr17:15433291(-) A-I      intronic chr17:15432107(-) A-I      intronic chr17:15408068(-) A-I      intronic chr17:15422702(-) A-I      intronic chr17:15432618(-) A-I      intronic chr17:15432666(-) A-I      intronic chr17:15427200(-) A-I      intronic chr17:15439421(-) A-I      intronic chr17:15426796(-) A-I      intronic chr17:15424766(-) A-I      intronic chr17:15424650(-) A-I      intronic chr17:15426762(-) A-I      intronic chr17:15434239(-) A-I      intronic chr17:15432185(-) A-I      intronic chr17:15432184(-) A-I      intronic chr17:15421440(-) A-I      intronic chr17:15434336(-) A-I      intronic chr17:15434252(-) A-I      intronic chr17:15424771(-) A-I      intronic chr17:15452885(-) A-I      intronic chr17:15427169(-) A-I      intronic chr17:15410963(-) A-I      intronic chr17:15423104(-) A-I      intronic chr17:15424761(-) A-I      intronic chr17:15423108(-) A-I      intronic chr17:15426763(-) A-I      intronic chr17:15463383(-) A-I      intronic chr17:15426798(-) A-I      intronic chr17:15426208(-) A-I      intronic chr17:15433332(-) A-I      intronic chr17:15426904(-) A-I      intronic chr17:15407953(-) A-I      intronic chr17:15434185(-) A-I      intronic chr17:15434260(-) A-I      intronic chr17:15426896(-) A-I      intronic chr17:15426841(-) A-I      intronic chr17:15407969(-) A-I      intronic chr17:15424633(-) A-I      intronic chr17:15427092(-) A-I      intronic chr17:15422717(-) A-I      intronic chr17:15408004(-) A-I      intronic chr17:15408114(-) A-I      intronic chr17:15438199(-) A-I      intronic chr17:15424584(-) A-I      intronic chr17:15421233(-) A-I      intronic chr17:15423051(-) A-I      intronic chr17:15427000(-) A-I      intronic chr17:15427208(-) A-I      intronic chr17:15426993(-) A-I      intronic chr17:15426357(-) A-I      intronic chr17:15432709(-) A-I      intronic chr17:15441841(-) A-I      3'UTR chr17:15434223(-) A-I      intronic chr17:15408049(-) A-I      intronic chr17:15427056(-) A-I      intronic chr17:15426100(-) A-I      intronic chr17:15442805(-) A-I      3'UTR chr17:15434253(-) A-I      intronic chr17:15433234(-) A-I      intronic chr17:15408141(-) A-I      intronic chr17:15424562(-) A-I      intronic chr17:15443360(-) A-I      3'UTR chr17:15426793(-) A-I      intronic chr17:15432139(-) A-I      intronic chr17:15408139(-) A-I      intronic chr17:15408129(-) A-I      intronic chr17:15433250(-) A-I      intronic chr17:15422752(-) A-I      intronic chr17:15421370(-) A-I      intronic chr17:15432050(-) A-I      intronic chr17:15443240(-) A-I      3'UTR chr17:15424622(-) A-I      intronic chr17:15426911(-) A-I      intronic chr17:15424718(-) A-I      intronic chr17:15432105(-) A-I      intronic chr17:15443238(-) A-I      3'UTR chr17:15434280(-) A-I      intronic chr17:15432679(-) A-I      intronic chr17:15422980(-) A-I      intronic chr17:15424699(-) A-I      intronic chr17:15443151(-) A-I      3'UTR chr17:15438086(-) A-I      intronic chr17:15427132(-) A-I      intronic chr17:15408082(-) A-I      intronic chr17:15432634(-) A-I      intronic chr17:15426406(-) A-I      intronic chr17:15424669(-) A-I      intronic chr17:15433173(-) A-I      intronic chr17:15442665(-) A-I      3'UTR chr17:15423060(-) A-I      intronic chr17:15426135(-) A-I      intronic chr17:15434159(-) A-I      intronic chr17:15434221(-) A-I      intronic chr17:15426191(-) A-I      intronic chr17:15434181(-) A-I      intronic chr17:15426789(-) A-I      intronic chr17:15407986(-) A-I      intronic chr17:15423038(-) A-I      intronic chr17:15432690(-) A-I      intronic chr17:15421360(-) A-I      intronic chr17:15434270(-) A-I      intronic chr17:15424755(-) A-I      intronic chr17:15421399(-) A-I      intronic chr17:15426127(-) A-I      intronic chr17:15432654(-) A-I      intronic chr17:15422968(-) A-I      intronic chr17:15465671(-) A-I      intronic chr17:15427066(-) A-I      intronic chr17:15432049(-) A-I      intronic chr17:15426849(-) A-I      intronic chr17:15432106(-) A-I      intronic chr17:15426207(-) A-I      intronic chr17:15433289(-) A-I      intronic chr17:15426140(-) A-I      intronic chr17:15422664(-) A-I      intronic chr17:15427060(-) A-I      intronic chr17:15406472(-) A-I      Syn:Gln->Gln chr17:15433331(-) A-I      intronic chr17:15423035(-) A-I      intronic chr17:15426939(-) A-I      intronic chr17:15424628(-) A-I      intronic chr17:15424670(-) A-I      intronic chr17:15424710(-) A-I      intronic chr17:15426794(-) A-I      intronic chr17:15426781(-) A-I      intronic chr17:15407965(-) A-I      intronic chr17:15434316(-) A-I      intronic chr17:15424575(-) A-I      intronic chr17:15434172(-) A-I      intronic chr17:15406637(-) A-I      ncRNA chr17:15421307(-) A-I      intronic chr17:15406581(-) A-I      ncRNA chr17:15421291(-) A-I      intronic chr17:15421035(-) A-I      intronic chr17:15433170(-) A-I      intronic chr17:15433209(-) A-I      intronic chr17:15408123(-) A-I      intronic chr17:15426232(-) A-I      intronic chr17:15406513(-) A-I      NonSyn:Lys->Glu chr17:15431988(-) A-I      intronic chr17:15406597(-) A-I      ncRNA chr17:15424659(-) A-I      intronic chr17:15406667(-) A-I      ncRNA chr17:15434236(-) A-I      intronic chr17:15432760(-) A-I      intronic chr17:15432683(-) A-I      intronic chr17:15432144(-) A-I      intronic chr17:15406499(-) A-I      Syn:Ser->Ser chr17:15433290(-) A-I      intronic chr17:15421382(-) A-I      intronic chr17:15434233(-) A-I      intronic chr17:15432130(-) A-I      intronic chr17:15414183(-) A-I      intronic chr17:15432076(-) A-I      intronic chr17:15426174(-) A-I      intronic chr17:15432091(-) A-I      intronic chr17:15434284(-) A-I      intronic chr17:15424686(-) A-I      intronic chr17:15432644(-) A-I      intronic chr17:15423057(-) A-I      intronic chr17:15424625(-) A-I      intronic chr17:15406693(-) A-I      ncRNA chr17:15421316(-) A-I      intronic chr17:15433205(-) A-I      intronic chr17:15421419(-) A-I      intronic chr17:15406669(-) A-I      ncRNA chr17:15434249(-) A-I      intronic chr17:15432752(-) A-I      intronic chr17:15406471(-) A-I      NonSyn:Ser->Gly chr17:15406650(-) A-I      ncRNA chr17:15441917(-) A-I      3'UTR chr17:15441891(-) A-I      3'UTR chr17:15441792(-) A-I      3'UTR chr17:15441715(-) A-I      3'UTR chr17:15443218(-) A-I      3'UTR chr17:15441921(-) A-I      3'UTR chr17:15441756(-) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TVP23C-CDRT4	chr17:15340411-15340412(-) m6A 3'UTR       27773535 chr17:15340418-15340419(-) m6A 3'UTR       27773535 chr17:15340453-15340454(-) m6A 3'UTR       27773535 chr17:15340581-15340582(-) m6A 3'UTR       24284625//25456834//24981863//27773535//27371828//22575960//22608085 chr17:15340600-15340601(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:15340631-15340632(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:15340649-15340650(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:15340788-15340789(-) m6A 3'UTR       24284625//27773535//22608085 chr17:15340826-15340827(-) m6A 3'UTR       24284625//27773535 chr17:15340937-15340938(-) m6A 3'UTR       24284625//27773535//22608085 chr17:15340973-15340974(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr17:15341075-15341076(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr17:15341153-15341154(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr17:15341168-15341169(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr17:15341197-15341198(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr17:15341273-15341274(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr17:15341341-15341342(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr17:15341365-15341366(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr17:15341395-15341396(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr17:15341403-15341404(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr17:15341422-15341423(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr17:15341433-15341434(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr17:15341473-15341474(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr17:15341497-15341498(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr17:15341504-15341505(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr17:15343590-15343591(-) m6A 3'UTR//CDS//intron       24284625//27773535//22608085 chr17:15355830-15355831(-) m6A intron       27773535 chr17:15405683-15405684(-) m6A intron       27773535 chr17:15405994-15405995(-) m6A intron       24284625//25456834//24981863//27773535//27773536//22608085 chr17:15406003-15406004(-) m6A intron       24284625//25456834//24981863//27773535//27773536//22608085 chr17:15406010-15406011(-) m6A intron       24284625//25456834//24981863//27773535//27773536//22608085 chr17:15406174-15406175(-) m6A intron       24284625//25456834//24981863//27773535//27371828 chr17:15406224-15406225(-) m6A intron       24284625//24981863//27773535 chr17:15406360-15406361(-) m6A intron       24981863//27773535 chr17:15406406-15406407(-) m6A intron       24981863//27773535 chr17:15419840-15419841(-) m6A intron       27773535 chr17:15419855-15419856(-) m6A intron       27773535 chr17:15419861-15419862(-) m6A intron       27773535 chr17:15419941-15419942(-) m6A intron       24284625//27773535//22608085 chr17:15419951-15419952(-) m6A intron       27773535//22608085 chr17:15419956-15419957(-) m6A intron       27773535//22608085 chr17:15465543-15465544(-) m6A intron       24981863 chr17:15465548-15465549(-) m6A intron       24981863 chr17:15466818-15466819(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	TVP23C-CDRT4	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: TVP23C-CDRT4

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).