Detail Information

Basic Information:


  VIRBase ID:  

HHID00011406

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           FXYD6-FXYD2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p FXYD6-FXYD2
miRBase
Accession/Entrez ID
MIMAT0004588 100533181
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - FXYD6

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase FXYD6-FXYD2
chr11:117690949-117690950(-) m6A 3'UTR       -
chr11:117690996-117690997(-) m6A 3'UTR       -
chr11:117693154-117693155(-) m6A CDS//intron       24981863
chr11:117693186-117693187(-) m6A CDS//intron       24981863
chr11:117693194-117693195(-) m6A CDS//intron       24981863
chr11:117693232-117693233(-) m6A intron       24981863
chr11:117693248-117693249(-) m6A intron       24981863
chr11:117693352-117693353(-) m6A intron       -
chr11:117693407-117693408(-) m6A CDS       24981863
chr11:117694901-117694902(-) m6A intron       24981863
chr11:117694919-117694920(-) m6A intron       24981863
chr11:117695288-117695289(-) m6A intron       24981863
chr11:117695436-117695437(-) m6A intron       24981863//26404942
chr11:117695456-117695457(-) m6A intron       24981863//26404942
chr11:117698723-117698724(-) m6A intron       24981863//26404942
chr11:117698748-117698749(-) m6A intron       24981863
chr11:117707874-117707875(-) m6A intron       25456834
chr11:117707903-117707904(-) m6A intron       25456834
chr11:117708061-117708062(-) m6A intron       25456834//24981863//22608085
chr11:117708106-117708107(-) m6A intron       25456834//24981863//22608085
chr11:117708140-117708141(-) m6A intron       25456834//22608085
chr11:117708173-117708174(-) m6A intron       22608085
chr11:117708440-117708441(-) m6A intron       24981863
chr11:117708464-117708465(-) m6A intron       24981863
chr11:117708575-117708576(-) m6A intron       24981863
chr11:117710520-117710521(-) m6A CDS       24981863
chr11:117711050-117711051(-) m6A CDS//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
FXYD6-FXYD2
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID
Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: FXYD6-FXYD2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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