Basic Information:

  VIRBase ID:  

HHID00011405

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          RPL36A-HNRNPH2:  NM_001199974     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	RPL36A-HNRNPH2
miRBase Accession/Entrez ID	MIMAT0004588	100529097
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RPL36A-HNRNPH2	chrX:100649168(+) A-I      intronic chrX:100649160(+) A-I      intronic chrX:100649159(+) A-I      intronic chrX:100649233(+) A-I      intronic chrX:100649232(+) A-I      intronic chrX:100649174(+) A-I      intronic chrX:100649148(+) A-I      intronic chrX:100649142(+) A-I      intronic chrX:100649068(+) A-I      intronic chrX:100649134(+) A-I      intronic chrX:100649132(+) A-I      intronic chrX:100649459(+) A-I      intronic chrX:100649122(+) A-I      intronic chrX:100649837(+) A-I      intronic chrX:100649223(+) A-I      intronic chrX:100649328(+) A-I      intronic chrX:100650176(+) A-I      intronic chrX:100650184(+) A-I      intronic chrX:100650185(+) A-I      intronic chrX:100649214(+) A-I      intronic chrX:100650200(+) A-I      intronic chrX:100649119(+) A-I      intronic chrX:100649201(+) A-I      intronic chrX:100649084(+) A-I      intronic chrX:100649170(+) A-I      intronic chrX:100650201(+) A-I      intronic chrX:100649167(+) A-I      intronic chrX:100650229(+) A-I      intronic chrX:100649169(+) A-I      intronic chrX:100649903(+) A-I      intronic chrX:100649154(+) A-I      intronic chrX:100650057(+) A-I      intronic chrX:100649246(+) A-I      intronic chrX:100649894(+) A-I      intronic chrX:100651706(+) A-I      intronic chrX:100651367(+) A-I      intronic chrX:100649210(+) A-I      intronic chrX:100650051(+) A-I      intronic chrX:100649876(+) A-I      intronic chrX:100649242(+) A-I      intronic chrX:100649108(+) A-I      intronic chrX:100649853(+) A-I      intronic chrX:100649435(+) A-I      intronic chrX:100649906(+) A-I      intronic chrX:100649448(+) A-I      intronic chrX:100649299(+) A-I      intronic chrX:100649976(+) A-I      intronic chrX:100649085(+) A-I      intronic chrX:100649902(+) A-I      intronic chrX:100649157(+) A-I      intronic chrX:100649442(+) A-I      intronic chrX:100649962(+) A-I      intronic chrX:100649877(+) A-I      intronic chrX:100649063(+) A-I      intronic chrX:100650045(+) A-I      intronic chrX:100649161(+) A-I      intronic chrX:100649217(+) A-I      intronic chrX:100649431(+) A-I      intronic chrX:100649922(+) A-I      intronic chrX:100649953(+) A-I      intronic chrX:100649163(+) A-I      intronic chrX:100649117(+) A-I      intronic chrX:100649959(+) A-I      intronic chrX:100649137(+) A-I      intronic chrX:100649918(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RPL36A-HNRNPH2	chrX:100646131-100646132(+) m6A intron       22575960 chrX:100646180-100646181(+) m6A intron       22575960 chrX:100646430-100646431(+) m6A intron       - chrX:100646461-100646462(+) m6A CDS       22575960 chrX:100646470-100646471(+) m6A CDS       22575960 chrX:100646505-100646506(+) Y CDS       26075521 chrX:100646680-100646681(+) m6A intron       22575960 chrX:100646689-100646690(+) m6A intron       - chrX:100646786-100646787(+) m6A CDS       27773535//22575960 chrX:100650328-100650329(+) m6A CDS//intron       27773535//22575960//22608085 chrX:100650420-100650421(+) m6A CDS//intron       27773535//22608085 chrX:100650505-100650506(+) m6A intron       27773535//22608085 chrX:100656624-100656625(+) Gm intron       - chrX:100658868-100658869(+) Cm intron       - chrX:100666939-100666940(+) Y CDS       25219674 chrX:100666948-100666949(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chrX:100667131-100667132(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chrX:100667155-100667156(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chrX:100667196-100667197(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chrX:100667204-100667205(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chrX:100667212-100667213(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	RPL36A-HNRNPH2	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: RPL36A-HNRNPH2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).