Detail Information

Basic Information:


  VIRBase ID:  

HHID00011402

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           ZNF605:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p ZNF605
miRBase
Accession/Entrez ID		 MIMAT0004588 100289635
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZNF605
chr12:133524580(-) A-I      intronic
chr12:133524557(-) A-I      intronic
chr12:133524543(-) A-I      intronic
chr12:133511154(-) A-I      intronic
chr12:133511164(-) A-I      intronic
chr12:133524544(-) A-I      intronic
chr12:133515066(-) A-I      intronic
chr12:133519692(-) A-I      intronic
chr12:133515055(-) A-I      intronic
chr12:133519767(-) A-I      intronic
chr12:133519781(-) A-I      intronic
chr12:133504014(-) A-I      intronic
chr12:133504057(-) A-I      intronic
chr12:133504076(-) A-I      intronic
chr12:133504128(-) A-I      intronic
chr12:133528879(-) A-I      intronic
chr12:133521670(-) A-I      intronic
chr12:133511152(-) A-I      intronic
chr12:133505534(-) A-I      intronic
chr12:133510862(-) A-I      intronic
chr12:133510608(-) A-I      intronic
chr12:133530089(-) A-I      intronic
chr12:133511180(-) A-I      intronic
chr12:133505884(-) A-I      intronic
chr12:133506422(-) A-I      intronic
chr12:133507599(-) A-I      intronic
chr12:133513797(-) A-I      intronic
chr12:133508829(-) A-I      intronic
chr12:133514972(-) A-I      intronic
chr12:133507716(-) A-I      intronic
chr12:133507640(-) A-I      intronic
chr12:133504239(-) A-I      intronic
chr12:133507631(-) A-I      intronic
chr12:133521646(-) A-I      intronic
chr12:133506725(-) A-I      intronic
chr12:133508642(-) A-I      intronic
chr12:133505586(-) A-I      intronic
chr12:133504303(-) A-I      intronic
chr12:133506871(-) A-I      intronic
chr12:133507730(-) A-I      intronic
chr12:133506431(-) A-I      intronic
chr12:133505455(-) A-I      intronic
chr12:133508668(-) A-I      intronic
chr12:133506763(-) A-I      intronic
chr12:133523930(-) A-I      intronic
chr12:133521666(-) A-I      intronic
chr12:133508603(-) A-I      intronic
chr12:133505395(-) A-I      intronic
chr12:133506781(-) A-I      intronic
chr12:133530283(-) A-I      intronic
chr12:133510796(-) A-I      intronic
chr12:133505811(-) A-I      intronic
chr12:133530190(-) A-I      intronic
chr12:133505415(-) A-I      intronic
chr12:133507511(-) A-I      intronic
chr12:133510821(-) A-I      intronic
chr12:133505380(-) A-I      intronic
chr12:133505426(-) A-I      intronic
chr12:133508666(-) A-I      intronic
chr12:133523752(-) A-I      intronic
chr12:133506409(-) A-I      intronic
chr12:133505802(-) A-I      intronic
chr12:133528984(-) A-I      intronic
chr12:133506757(-) A-I      intronic
chr12:133506288(-) A-I      intronic
chr12:133505432(-) A-I      intronic
chr12:133506773(-) A-I      intronic
chr12:133508763(-) A-I      intronic
chr12:133505377(-) A-I      intronic
chr12:133511170(-) A-I      intronic
chr12:133530290(-) A-I      intronic
chr12:133528925(-) A-I      intronic
chr12:133506471(-) A-I      intronic
chr12:133507680(-) A-I      intronic
chr12:133528798(-) A-I      intronic
chr12:133507648(-) A-I      intronic
chr12:133530177(-) A-I      intronic
chr12:133510586(-) A-I      intronic
chr12:133506893(-) A-I      intronic
chr12:133521754(-) A-I      intronic
chr12:133519714(-) A-I      intronic
chr12:133505363(-) A-I      intronic
chr12:133511192(-) A-I      intronic
chr12:133506765(-) A-I      intronic
chr12:133505861(-) A-I      intronic
chr12:133505401(-) A-I      intronic
chr12:133521746(-) A-I      intronic
chr12:133506868(-) A-I      intronic
chr12:133504381(-) A-I      intronic
chr12:133505494(-) A-I      intronic
chr12:133528995(-) A-I      intronic
chr12:133506728(-) A-I      intronic
chr12:133511282(-) A-I      intronic
chr12:133521823(-) A-I      intronic
chr12:133508592(-) A-I      intronic
chr12:133523737(-) A-I      intronic
chr12:133530084(-) A-I      intronic
chr12:133513823(-) A-I      intronic
chr12:133505545(-) A-I      intronic
chr12:133508567(-) A-I      intronic
chr12:133505471(-) A-I      intronic
chr12:133507587(-) A-I      intronic
chr12:133506815(-) A-I      intronic
chr12:133508602(-) A-I      intronic
chr12:133506870(-) A-I      intronic
chr12:133507670(-) A-I      intronic
chr12:133504349(-) A-I      intronic
chr12:133511209(-) A-I      intronic
chr12:133528786(-) A-I      intronic
chr12:133505790(-) A-I      intronic
chr12:133505871(-) A-I      intronic
chr12:133506719(-) A-I      intronic
chr12:133505394(-) A-I      intronic
chr12:133510867(-) A-I      intronic
chr12:133506362(-) A-I      intronic
chr12:133506311(-) A-I      intronic
chr12:133521822(-) A-I      intronic
chr12:133508727(-) A-I      intronic
chr12:133505789(-) A-I      intronic
chr12:133505526(-) A-I      intronic
chr12:133514983(-) A-I      intronic
chr12:133505539(-) A-I      intronic
chr12:133510753(-) A-I      intronic
chr12:133508731(-) A-I      intronic
chr12:133513829(-) A-I      intronic
chr12:133506852(-) A-I      intronic
chr12:133508826(-) A-I      intronic
chr12:133505759(-) A-I      intronic
chr12:133530239(-) A-I      intronic
chr12:133506714(-) A-I      intronic
chr12:133506892(-) A-I      intronic
chr12:133506348(-) A-I      intronic
chr12:133508758(-) A-I      intronic
chr12:133515119(-) A-I      intronic
chr12:133506816(-) A-I      intronic
chr12:133505491(-) A-I      intronic
chr12:133514855(-) A-I      intronic
chr12:133505540(-) A-I      intronic
chr12:133506808(-) A-I      intronic
chr12:133504402(-) A-I      intronic
chr12:133507584(-) A-I      intronic
chr12:133505368(-) A-I      intronic
chr12:133506276(-) A-I      intronic
chr12:133507595(-) A-I      intronic
chr12:133506468(-) A-I      intronic
chr12:133511240(-) A-I      intronic
chr12:133507551(-) A-I      intronic
chr12:133507550(-) A-I      intronic
chr12:133528935(-) A-I      intronic
chr12:133510733(-) A-I      intronic
chr12:133504339(-) A-I      intronic
chr12:133510598(-) A-I      intronic
chr12:133505869(-) A-I      intronic
chr12:133507759(-) A-I      intronic
chr12:133506866(-) A-I      intronic
chr12:133508764(-) A-I      intronic
chr12:133507714(-) A-I      intronic
chr12:133519759(-) A-I      intronic
chr12:133506819(-) A-I      intronic
chr12:133521745(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZNF605
chr12:133521666(-) A-I intron -    15258596
chr12:133521745(-) A-I intron -    15258596
chr12:133521746(-) A-I intron -    15258596
chr12:133506819(-) A-I intron -    22327324

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZNF605
chr12:133498144-133498145(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133498208-133498209(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133498626-133498627(-) m6A 3'UTR       27773535
chr12:133498816-133498817(-) m6A 3'UTR       27773535
chr12:133498823-133498824(-) m6A 3'UTR       27773535
chr12:133499899-133499900(-) m6A 3'UTR       27773535//22608085
chr12:133499940-133499941(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133499955-133499956(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133499986-133499987(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133500000-133500001(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133500062-133500063(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr12:133500069-133500070(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr12:133500107-133500108(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr12:133500124-133500125(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr12:133500154-133500155(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr12:133500189-133500190(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr12:133500205-133500206(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr12:133500263-133500264(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133500312-133500313(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133500430-133500431(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133500458-133500459(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133500490-133500491(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133500511-133500512(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133500596-133500597(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133500635-133500636(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133500651-133500652(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133500695-133500696(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133500717-133500718(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133500728-133500729(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133500791-133500792(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133500817-133500818(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133500901-133500902(-) m6A 3'UTR       25456834//24981863
chr12:133500912-133500913(-) m6A 3'UTR       25456834//24981863
chr12:133500961-133500962(-) m6A 3'UTR       25456834//24981863
chr12:133500973-133500974(-) m6A 3'UTR       25456834//24981863
chr12:133501713-133501714(-) m6A 3'UTR       27773535
chr12:133501753-133501754(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133501782-133501783(-) m6A 3'UTR       24981863//27773535//22608085
chr12:133501874-133501875(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr12:133502014-133502015(-) m6A CDS       24981863//27773535//22608085
chr12:133502123-133502124(-) m6A CDS       24981863//27773535//22608085
chr12:133502206-133502207(-) m6A CDS       24981863//27773535//22608085
chr12:133502291-133502292(-) m6A CDS       27773535
chr12:133502392-133502393(-) m6A CDS       27773535
chr12:133502431-133502432(-) m6A CDS       27773535
chr12:133502459-133502460(-) m6A CDS       27773535
chr12:133502476-133502477(-) m6A CDS       27773535
chr12:133502560-133502561(-) m6A CDS       27773535//22608085
chr12:133502599-133502600(-) m6A CDS       24981863//27773535//22608085
chr12:133502627-133502628(-) m6A CDS       24981863//27773535//22608085
chr12:133502654-133502655(-) m6A CDS       24981863//27773535//22608085
chr12:133502709-133502710(-) m6A CDS       24981863//27773535//22608085
chr12:133502738-133502739(-) m6A CDS       24284625//24981863//27773535//22608085
chr12:133502753-133502754(-) m6A CDS       24284625//24981863//27773535//22608085
chr12:133502838-133502839(-) m6A CDS       24981863//27773535//22608085
chr12:133502879-133502880(-) m6A CDS       24284625//24981863//27773535//22608085
chr12:133502896-133502897(-) m6A CDS       24284625//24981863//27773535//22608085
chr12:133502963-133502964(-) m6A CDS       24284625//24981863//27773535//22608085
chr12:133502999-133503000(-) m6A CDS       24284625//24981863//27773535//22608085
chr12:133503047-133503048(-) m6A CDS       24284625//24981863//27773535//22608085
chr12:133503074-133503075(-) m6A CDS       24284625//24981863//27773535//22608085
chr12:133503215-133503216(-) m6A CDS       24284625//25456834//24981863//27773535//22608085
chr12:133503232-133503233(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085
chr12:133503316-133503317(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085
chr12:133503478-133503479(-) m6A CDS//exon       24284625//24981863//27773535//22608085
chr12:133503488-133503489(-) m6A CDS//exon       24284625//24981863//27773535//22608085
chr12:133503518-133503519(-) m6A CDS//exon       24284625//24981863//27773535//22608085
chr12:133503617-133503618(-) m6A CDS//exon       24284625//24981863//27773535//22608085
chr12:133503633-133503634(-) m6A CDS//exon       24284625//24981863//27773535//22608085
chr12:133503702-133503703(-) m6A CDS//exon       24284625//24981863//27773535//22608085
chr12:133509306-133509307(-) m6A CDS//intron       24284625
chr12:133522248-133522249(-) m6A 5'UTR//exon       27773535
chr12:133522266-133522267(-) m6A 5'UTR//exon       27773535
chr12:133522299-133522300(-) m6A 5'UTR//exon       27773535
chr12:133522325-133522326(-) m6A 5'UTR//exon       27773535
chr12:133522361-133522362(-) m6A 5'UTR//exon       27773535
chr12:133522366-133522367(-) m6A 5'UTR//exon       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
ZNF605
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: ZNF605

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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