Detail Information

Basic Information:


  VIRBase ID:  

HHID00011399

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           NEMP2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p NEMP2
miRBase
Accession/Entrez ID		 MIMAT0004588 100131211
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - TMEM194B

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NEMP2
chr2:191384220(-) A-I      intronic
chr2:191384219(-) A-I      intronic
chr2:191384196(-) A-I      intronic
chr2:191375352(-) A-I      intronic
chr2:191374598(-) A-I      intronic
chr2:191384062(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NEMP2
chr2:191371658-191371659(-) m6A 3'UTR       27773535
chr2:191373386-191373387(-) m6A 3'UTR       24981863
chr2:191373478-191373479(-) m6A 3'UTR       24981863//27773535
chr2:191373487-191373488(-) m6A 3'UTR       24981863//27773535
chr2:191373494-191373495(-) m6A 3'UTR       24981863//27773535
chr2:191373542-191373543(-) m6A 3'UTR       24981863//27773535//22608085
chr2:191373556-191373557(-) m6A 3'UTR       24981863//27773535//22608085
chr2:191373606-191373607(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr2:191373647-191373648(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr2:191373771-191373772(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr2:191373793-191373794(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr2:191373812-191373813(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr2:191373837-191373838(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr2:191373883-191373884(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr2:191375173-191375174(-) m6A CDS       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
NEMP2
Exosome Blood     -
Nucleoplasm K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: NEMP2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

Starting a new search, please wait ...