Basic Information:

  VIRBase ID:  

HHID00011290

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          CATSPERE:  NM_001242340     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	CATSPERE
miRBase Accession/Entrez ID	MIMAT0004588	257044
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C10orf101//C1orf101

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CATSPERE	chr1:244680898(+) A-I      intronic chr1:244644475(+) A-I      intronic chr1:244669179(+) A-I      intronic chr1:244669148(+) A-I      intronic chr1:244680964(+) A-I      intronic chr1:244680954(+) A-I      intronic chr1:244680952(+) A-I      intronic chr1:244680854(+) A-I      intronic chr1:244669151(+) A-I      intronic chr1:244669161(+) A-I      intronic chr1:244669169(+) A-I      intronic chr1:244680890(+) A-I      intronic chr1:244649074(+) A-I      intronic chr1:244680873(+) A-I      intronic chr1:244680851(+) A-I      intronic chr1:244649078(+) A-I      intronic chr1:244680827(+) A-I      intronic chr1:244680896(+) A-I      intronic chr1:244739873(+) A-I      intronic chr1:244739870(+) A-I      intronic chr1:244739862(+) A-I      intronic chr1:244739859(+) A-I      intronic chr1:244680897(+) A-I      intronic chr1:244649085(+) A-I      intronic chr1:244649111(+) A-I      intronic chr1:244669142(+) A-I      intronic chr1:244669145(+) A-I      intronic chr1:244680987(+) A-I      intronic chr1:244739846(+) A-I      intronic chr1:244774817(+) A-I      intronic chr1:244774812(+) A-I      intronic chr1:244751385(+) A-I      intronic chr1:244751376(+) A-I      intronic chr1:244751375(+) A-I      intronic chr1:244751373(+) A-I      intronic chr1:244743400(+) A-I      intronic chr1:244736530(+) A-I      intronic chr1:244736526(+) A-I      intronic chr1:244721597(+) A-I      intronic chr1:244680884(+) A-I      intronic chr1:244680878(+) A-I      intronic chr1:244649084(+) A-I      intronic chr1:244638146(+) A-I      intronic chr1:244631966(+) A-I      intronic chr1:244772782(+) A-I      intronic chr1:244649236(+) A-I      intronic chr1:244773114(+) A-I      intronic chr1:244689674(+) A-I      intronic chr1:244743419(+) A-I      intronic chr1:244644395(+) A-I      intronic chr1:244789555(+) A-I      intronic chr1:244773087(+) A-I      intronic chr1:244795442(+) A-I      intronic chr1:244743443(+) A-I      intronic chr1:244639513(+) A-I      intronic chr1:244787947(+) A-I      intronic chr1:244787953(+) A-I      intronic chr1:244649058(+) A-I      intronic chr1:244680038(+) A-I      intronic chr1:244671877(+) A-I      intronic chr1:244642265(+) A-I      intronic chr1:244645837(+) A-I      intronic chr1:244795575(+) A-I      intronic chr1:244679963(+) A-I      intronic chr1:244642271(+) A-I      intronic chr1:244741644(+) A-I      intronic chr1:244645492(+) A-I      intronic chr1:244672068(+) A-I      intronic chr1:244639516(+) A-I      intronic chr1:244639486(+) A-I      intronic chr1:244690031(+) A-I      intronic chr1:244745932(+) A-I      intronic chr1:244639487(+) A-I      intronic chr1:244672113(+) A-I      intronic chr1:244798286(+) A-I      intronic chr1:244645853(+) A-I      intronic chr1:244632140(+) A-I      intronic chr1:244649023(+) A-I      intronic chr1:244638172(+) A-I      intronic chr1:244798327(+) A-I      intronic chr1:244773290(+) A-I      intronic chr1:244680004(+) A-I      intronic chr1:244773093(+) A-I      intronic chr1:244743439(+) A-I      intronic chr1:244638597(+) A-I      intronic chr1:244743442(+) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	CATSPERE	Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: CATSPERE

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).