Basic Information:

  VIRBase ID:  

HHID00011241

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          OLFML2A:  NM_001282715     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	OLFML2A
miRBase Accession/Entrez ID	MIMAT0004588	169611
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PRO34319

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	OLFML2A	chr9:127565257(+) A-I      intronic chr9:127566788(+) A-I      intronic chr9:127567105(+) A-I      intronic chr9:127556147(+) A-I      intronic chr9:127548207(+) A-I      intronic chr9:127560951(+) A-I      intronic chr9:127560937(+) A-I      intronic chr9:127566770(+) A-I      intronic chr9:127566769(+) A-I      intronic chr9:127566747(+) A-I      intronic chr9:127560948(+) A-I      intronic chr9:127560917(+) A-I      intronic chr9:127560903(+) A-I      intronic chr9:127560955(+) A-I      intronic chr9:127574613(+) A-I      3'UTR chr9:127574584(+) A-I      3'UTR chr9:127574596(+) A-I      3'UTR chr9:127574579(+) A-I      3'UTR chr9:127574557(+) A-I      3'UTR chr9:127575283(+) A-I      3'UTR chr9:127575288(+) A-I      3'UTR chr9:127575348(+) A-I      3'UTR chr9:127575300(+) A-I      3'UTR chr9:127557862(+) A-I      intronic chr9:127566734(+) A-I      intronic chr9:127550112(+) A-I      intronic chr9:127556139(+) A-I      intronic chr9:127560858(+) A-I      intronic chr9:127546622(+) A-I      intronic chr9:127566741(+) A-I      intronic chr9:127557882(+) A-I      intronic chr9:127559481(+) A-I      intronic chr9:127557838(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	OLFML2A	chr9:127566734(+) A-I intron -    21960545 chr9:127566741(+) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	OLFML2A	chr9:127549263-127549264(+) m6A CDS       24284625 chr9:127549269-127549270(+) m6A CDS       24284625 chr9:127549380-127549381(+) m6A CDS       24284625 chr9:127549397-127549398(+) m6A CDS       24284625 chr9:127557348-127557349(+) m6A CDS//intron       24284625 chr9:127557396-127557397(+) m6A CDS//intron       24284625 chr9:127563198-127563199(+) m6A 5'UTR//intron       24284625 chr9:127563717-127563718(+) m6A CDS       24284625 chr9:127563756-127563757(+) m6A CDS       24284625 chr9:127563772-127563773(+) m6A CDS       24284625 chr9:127566498-127566499(+) m6A CDS       24284625 chr9:127570098-127570099(+) m6A CDS       24284625 chr9:127570152-127570153(+) m6A CDS       24284625 chr9:127570203-127570204(+) m6A CDS       24284625 chr9:127570233-127570234(+) m6A CDS       24284625 chr9:127572185-127572186(+) m6A CDS       24284625//25456834//24981863//22575960 chr9:127572257-127572258(+) m6A CDS       24284625//25456834//24981863//22575960 chr9:127572282-127572283(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr9:127572290-127572291(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr9:127572392-127572393(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr9:127572421-127572422(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr9:127572433-127572434(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr9:127572449-127572450(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr9:127572461-127572462(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr9:127572497-127572498(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr9:127572647-127572648(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr9:127572697-127572698(+) m6A 3'UTR       24284625//25456834//24981863//22575960 chr9:127572804-127572805(+) m6A 3'UTR       24284625//25456834//24981863//22575960 chr9:127572952-127572953(+) m6A 3'UTR       24284625//24209618//24981863 chr9:127572962-127572963(+) Cm 3'UTR       - chr9:127572973-127572974(+) m6A 3'UTR       24284625//24209618//24981863 chr9:127573041-127573042(+) m6A 3'UTR       24284625//24981863 chr9:127573066-127573067(+) m6A 3'UTR       24284625//24981863 chr9:127573663-127573664(+) m6A 3'UTR       24284625 chr9:127573714-127573715(+) m6A 3'UTR       24284625 chr9:127573886-127573887(+) m6A 3'UTR       25456834//24981863 chr9:127573914-127573915(+) m6A 3'UTR       25456834//24981863 chr9:127573929-127573930(+) m6A 3'UTR       25456834//24981863 chr9:127573934-127573935(+) m6A 3'UTR       25456834//24981863 chr9:127573956-127573957(+) m6A 3'UTR       25456834//24981863 chr9:127574288-127574289(+) m6A 3'UTR       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	OLFML2A	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: OLFML2A

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).