Basic Information:

  VIRBase ID:  

HHID00011216

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          CLEC2L:  NM_001353368     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	CLEC2L
miRBase Accession/Entrez ID	MIMAT0004588	154790
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CLEC2L	chr7:139215397(+) A-I      intronic chr7:139218257(+) A-I      intronic chr7:139225558(+) A-I      intronic chr7:139215484(+) A-I      intronic chr7:139215491(+) A-I      intronic chr7:139225567(+) A-I      intronic chr7:139215394(+) A-I      intronic chr7:139215403(+) A-I      intronic chr7:139225590(+) A-I      intronic chr7:139218254(+) A-I      intronic chr7:139218251(+) A-I      intronic chr7:139225786(+) A-I      intronic chr7:139218376(+) A-I      intronic chr7:139218231(+) A-I      intronic chr7:139215407(+) A-I      intronic chr7:139225616(+) A-I      intronic chr7:139223240(+) A-I      intronic chr7:139215436(+) A-I      intronic chr7:139221642(+) A-I      intronic chr7:139225571(+) A-I      intronic chr7:139214555(+) A-I      intronic chr7:139215412(+) A-I      intronic chr7:139214851(+) A-I      intronic chr7:139225990(+) A-I      intronic chr7:139215408(+) A-I      intronic chr7:139221556(+) A-I      intronic chr7:139215301(+) A-I      intronic chr7:139225618(+) A-I      intronic chr7:139214850(+) A-I      intronic chr7:139218182(+) A-I      intronic chr7:139225682(+) A-I      intronic chr7:139225709(+) A-I      intronic chr7:139225585(+) A-I      intronic chr7:139225640(+) A-I      intronic chr7:139214693(+) A-I      intronic chr7:139215479(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CLEC2L	chr7:139219566-139219567(+) Y intron       25219674 chr7:139224285-139224286(+) m6A exon//intron       27773535 chr7:139224375-139224376(+) m6A exon//intron       27773535 chr7:139224493-139224494(+) m6A exon//intron       27773535 chr7:139224531-139224532(+) m6A exon//intron       27773535 chr7:139224556-139224557(+) m6A exon//intron       27773535 chr7:139224566-139224567(+) m6A exon//intron       27773535 chr7:139224581-139224582(+) m6A exon//intron       27773535 chr7:139224633-139224634(+) m6A exon//intron       27773535 chr7:139224746-139224747(+) m6A exon//intron       27773535 chr7:139224761-139224762(+) m6A exon//intron       27773535 chr7:139224812-139224813(+) m6A exon//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	CLEC2L	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: CLEC2L

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).