Basic Information:

  VIRBase ID:  

HHID00011205

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          CCDC50:  NM_178335     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	CCDC50
miRBase Accession/Entrez ID	MIMAT0004588	152137
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C3orf6//DFNA44//YMER

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CCDC50	chr3:191110237(+) A-I      3'UTR chr3:191110668(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CCDC50	chr3:191055259(+) G-A intron -    22484847 chr3:191081863(+) A-T intron -    22484847 chr3:191088286(+) T-G intron -    22484847 chr3:191088287(+) G-T intron -    22484847 chr3:191110789(+) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CCDC50	chr3:191047039-191047040(+) m6A 5'UTR       24981863 chr3:191047103-191047104(+) m6A 5'UTR       24981863 chr3:191047279-191047280(+) m6A 5'UTR       24981863 chr3:191075909-191075910(+) m6A CDS       24981863//27773535 chr3:191078860-191078861(+) m6A CDS       24981863//27773535 chr3:191078868-191078869(+) m6A CDS       24981863//27773535 chr3:191087763-191087764(+) m6A CDS//exon       24981863//27773535//22608085 chr3:191087862-191087863(+) m6A exon//intron       24981863//27773535 chr3:191087875-191087876(+) m6A exon//intron       24981863//27773535 chr3:191087912-191087913(+) m6A exon//intron       27773535 chr3:191092899-191092900(+) m6A CDS//intron       25456834//22608085 chr3:191092908-191092909(+) m6A CDS//intron       25456834//22608085 chr3:191092927-191092928(+) m6A CDS//intron       25456834//24981863//22608085 chr3:191092950-191092951(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr3:191092956-191092957(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr3:191092970-191092971(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr3:191092986-191092987(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr3:191093042-191093043(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr3:191093106-191093107(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr3:191093167-191093168(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr3:191093185-191093186(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr3:191093202-191093203(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr3:191093285-191093286(+) m6A CDS//intron       25456834//24981863//22608085 chr3:191093316-191093317(+) m6A CDS//intron       25456834//24981863//22608085 chr3:191093329-191093330(+) m6A CDS//intron       25456834//24981863//22608085 chr3:191098041-191098042(+) m6A CDS       24981863//27773535 chr3:191098056-191098057(+) m6A CDS       24981863//27773535 chr3:191098488-191098489(+) m6A CDS       24981863//27773535 chr3:191098692-191098693(+) m6A CDS       24981863//27773535 chr3:191098707-191098708(+) m6A CDS       24981863//27773535 chr3:191100540-191100541(+) m6A CDS       24981863//27773535 chr3:191100581-191100582(+) m6A CDS       24981863//27773535 chr3:191107340-191107341(+) m6A CDS       24981863//27773535//22608085 chr3:191109542-191109543(+) m6A CDS       24981863//27773535//22608085 chr3:191109551-191109552(+) m6A 3'UTR       24981863//27773535//22608085 chr3:191109576-191109577(+) m6A 3'UTR       24981863//27773535//22608085 chr3:191109809-191109810(+) m6A 3'UTR       27773535 chr3:191109819-191109820(+) m6A 3'UTR       27773535 chr3:191109910-191109911(+) m6A 3'UTR       27773535 chr3:191113376-191113377(+) m6A 3'UTR       24981863//22608085 chr3:191113391-191113392(+) m6A 3'UTR       24981863//22608085 chr3:191113408-191113409(+) m6A 3'UTR       24981863//22608085 chr3:191113472-191113473(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	CCDC50	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: CCDC50

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).