Basic Information:

  VIRBase ID:  

HHID00011178

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          POGLUT3:  NM_001363502     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	POGLUT3
miRBase Accession/Entrez ID	MIMAT0004588	143888
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	KDELC2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	POGLUT3	chr11:108364348(-) A-I      intronic chr11:108364419(-) A-I      intronic chr11:108354575(-) A-I      intronic chr11:108346998(-) A-I      intronic chr11:108350699(-) A-I      intronic chr11:108350844(-) A-I      intronic chr11:108360452(-) A-I      intronic chr11:108353236(-) A-I      intronic chr11:108346985(-) A-I      intronic chr11:108353306(-) A-I      intronic chr11:108362254(-) A-I      intronic chr11:108360557(-) A-I      intronic chr11:108354498(-) A-I      intronic chr11:108354596(-) A-I      intronic chr11:108346958(-) A-I      intronic chr11:108346860(-) A-I      intronic chr11:108346806(-) A-I      intronic chr11:108350615(-) A-I      intronic chr11:108355283(-) A-I      intronic chr11:108346378(-) A-I      intronic chr11:108355303(-) A-I      intronic chr11:108355420(-) A-I      intronic chr11:108350653(-) A-I      intronic chr11:108360561(-) A-I      intronic chr11:108356119(-) A-I      intronic chr11:108346766(-) A-I      intronic chr11:108354572(-) A-I      intronic chr11:108355439(-) A-I      intronic chr11:108356137(-) A-I      intronic chr11:108346805(-) A-I      intronic chr11:108355400(-) A-I      intronic chr11:108356151(-) A-I      intronic chr11:108356586(-) A-I      intronic chr11:108356604(-) A-I      intronic chr11:108356658(-) A-I      intronic chr11:108360445(-) A-I      intronic chr11:108360446(-) A-I      intronic chr11:108354573(-) A-I      intronic chr11:108354464(-) A-I      intronic chr11:108353351(-) A-I      intronic chr11:108344065(-) A-I      3'UTR chr11:108343895(-) A-I      3'UTR chr11:108344011(-) A-I      3'UTR chr11:108343961(-) A-I      3'UTR chr11:108343886(-) A-I      3'UTR chr11:108343922(-) A-I      3'UTR chr11:108343948(-) A-I      3'UTR chr11:108348841(-) A-I      Syn:Glu->Glu chr11:108346297(-) A-I      intronic chr11:108362269(-) A-I      intronic chr11:108355315(-) A-I      intronic chr11:108364351(-) A-I      intronic chr11:108355469(-) A-I      intronic chr11:108346812(-) A-I      intronic chr11:108354534(-) A-I      intronic chr11:108366026(-) A-I      intronic chr11:108355320(-) A-I      intronic chr11:108346384(-) A-I      intronic chr11:108346375(-) A-I      intronic chr11:108355244(-) A-I      intronic chr11:108356649(-) A-I      intronic chr11:108353326(-) A-I      intronic chr11:108348074(-) A-I      intronic chr11:108346771(-) A-I      intronic chr11:108356097(-) A-I      intronic chr11:108348119(-) A-I      intronic chr11:108353294(-) A-I      intronic chr11:108355323(-) A-I      intronic chr11:108355338(-) A-I      intronic chr11:108353302(-) A-I      intronic chr11:108355401(-) A-I      intronic chr11:108356657(-) A-I      intronic chr11:108356694(-) A-I      intronic chr11:108359047(-) A-I      intronic chr11:108366049(-) A-I      intronic chr11:108354504(-) A-I      intronic chr11:108362273(-) A-I      intronic chr11:108346224(-) A-I      intronic chr11:108362236(-) A-I      intronic chr11:108346989(-) A-I      intronic chr11:108353467(-) A-I      intronic chr11:108364288(-) A-I      intronic chr11:108353224(-) A-I      intronic chr11:108353348(-) A-I      intronic chr11:108360881(-) A-I      intronic chr11:108354458(-) A-I      intronic chr11:108353308(-) A-I      intronic chr11:108364289(-) A-I      intronic chr11:108343987(-) A-I      3'UTR chr11:108343869(-) A-I      3'UTR chr11:108344056(-) A-I      3'UTR chr11:108344073(-) A-I      3'UTR chr11:108344057(-) A-I      3'UTR chr11:108343921(-) A-I      3'UTR

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	POGLUT3	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: POGLUT3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).