Detail Information

Basic Information:


  VIRBase ID:  

HHID00011123

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           FAM210A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p FAM210A
miRBase
Accession/Entrez ID		 MIMAT0004588 125228
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - C18orf19//HsT2329

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR FAM210A
chr18:13710362(-) A-I      intronic
chr18:13724825(-) A-I      intronic
chr18:13678453(-) A-I      intronic
chr18:13724910(-) A-I      intronic
chr18:13711213(-) A-I      intronic
chr18:13710441(-) A-I      intronic
chr18:13710425(-) A-I      intronic
chr18:13710279(-) A-I      intronic
chr18:13665205(-) A-I      3'UTR
chr18:13665199(-) A-I      3'UTR
chr18:13711262(-) A-I      intronic
chr18:13710294(-) A-I      intronic
chr18:13665216(-) A-I      3'UTR
chr18:13710280(-) A-I      intronic
chr18:13672476(-) A-I      intronic
chr18:13698268(-) A-I      intronic
chr18:13699008(-) A-I      intronic
chr18:13711207(-) A-I      intronic
chr18:13710347(-) A-I      intronic
chr18:13684372(-) A-I      intronic
chr18:13670959(-) A-I      intronic
chr18:13678407(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase FAM210A
chr18:13663468-13663469(-) m6A 3'UTR       27773535
chr18:13663500-13663501(-) m6A 3'UTR       27773535
chr18:13663528-13663529(-) m6A 3'UTR       27773535
chr18:13663611-13663612(-) m6A 3'UTR       27773535
chr18:13666283-13666284(-) m6A 3'UTR//exon       27773535
chr18:13666427-13666428(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr18:13666516-13666517(-) m6A 3'UTR//CDS//exon       24284625//24981863//28052920//27773535//27371828//22608085
chr18:13666538-13666539(-) m6A 3'UTR//CDS//exon       24284625//24981863//28052920//27773535//27371828//22608085
chr18:13666549-13666550(-) m6A 3'UTR//CDS//exon       24284625//24981863//28052920//27773535//27371828//22608085
chr18:13666582-13666583(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//22608085
chr18:13666596-13666597(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828//22608085
chr18:13666672-13666673(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828
chr18:13681683-13681684(-) m6A CDS//exon//intron       24981863
chr18:13681691-13681692(-) m6A CDS//exon//intron       24981863
chr18:13681726-13681727(-) m6A CDS//exon//intron       24981863//27773535//22608085
chr18:13681763-13681764(-) m6A CDS//exon//intron       24981863//27773535//22608085
chr18:13681917-13681918(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:13681974-13681975(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:13681995-13681996(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:13682019-13682020(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:13682030-13682031(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:13682054-13682055(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:13682095-13682096(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr18:13687761-13687762(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr18:13687788-13687789(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr18:13687840-13687841(-) m6A 5'UTR//intron       24209618//27371828
chr18:13726437-13726438(-) m6A 5'UTR//exon       24284625//24209618//24981863//27371828//27773536//22575960
chr18:13726589-13726590(-) m6A 5'UTR//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
FAM210A
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: FAM210A

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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