Basic Information:

  VIRBase ID:  

HHID00011086

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          PIK3IP1:  NM_052880     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	PIK3IP1
miRBase Accession/Entrez ID	MIMAT0004588	113791
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HGFL//hHGFL(S)//TrIP

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PIK3IP1	chr22:31681258(-) A-I      intronic chr22:31681261(-) A-I      intronic chr22:31681262(-) A-I      intronic chr22:31681282(-) A-I      intronic chr22:31683129(-) A-I      intronic chr22:31683179(-) A-I      intronic chr22:31683119(-) A-I      intronic chr22:31683173(-) A-I      intronic chr22:31683184(-) A-I      intronic chr22:31683185(-) A-I      intronic chr22:31683201(-) A-I      intronic chr22:31683218(-) A-I      intronic chr22:31684160(-) A-I      intronic chr22:31684171(-) A-I      intronic chr22:31683477(-) A-I      intronic chr22:31683512(-) A-I      intronic chr22:31683583(-) A-I      intronic chr22:31683589(-) A-I      intronic chr22:31684142(-) A-I      intronic chr22:31683092(-) A-I      intronic chr22:31683125(-) A-I      intronic chr22:31683164(-) A-I      intronic chr22:31683168(-) A-I      intronic chr22:31683172(-) A-I      intronic chr22:31683174(-) A-I      intronic chr22:31683177(-) A-I      intronic chr22:31683187(-) A-I      intronic chr22:31683231(-) A-I      intronic chr22:31683075(-) A-I      intronic chr22:31681896(-) A-I      intronic chr22:31683181(-) A-I      intronic chr22:31683588(-) A-I      intronic chr22:31683182(-) A-I      intronic chr22:31683454(-) A-I      intronic chr22:31679625(-) A-I      intronic chr22:31680084(-) A-I      intronic chr22:31682037(-) A-I      intronic chr22:31684296(-) A-I      intronic chr22:31679982(-) A-I      intronic chr22:31684281(-) A-I      intronic chr22:31684145(-) A-I      intronic chr22:31679918(-) A-I      intronic chr22:31681914(-) A-I      intronic chr22:31684241(-) A-I      intronic chr22:31683428(-) A-I      intronic chr22:31683284(-) A-I      intronic chr22:31682031(-) A-I      intronic chr22:31680083(-) A-I      intronic chr22:31684197(-) A-I      intronic chr22:31683595(-) A-I      intronic chr22:31684199(-) A-I      intronic chr22:31684268(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PIK3IP1	chr22:31682207(-) A-I intron -    21960545

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PIK3IP1	chr22:31678973-31678974(-) m6A 3'UTR//exon       24209618//25456834//24981863//27773535//27371828//22608085 chr22:31678998-31678999(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr22:31679026-31679027(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr22:31679039-31679040(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr22:31679083-31679084(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr22:31679134-31679135(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr22:31679158-31679159(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr22:31679255-31679256(-) m6A 3'UTR//CDS//exon       24209618//27773535//27371828 chr22:31685050-31685051(-) m6A 3'UTR//intron       24209618//27773535 chr22:31687245-31687246(-) m6A CDS       27371828 chr22:31687269-31687270(-) m6A CDS       27371828 chr22:31688370-31688371(-) m6A 5'UTR       24981863//27371828 chr22:31688409-31688410(-) m6A 5'UTR       24981863//27371828 chr22:31688446-31688447(-) m6A 5'UTR       24981863//27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	PIK3IP1	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: PIK3IP1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).