Basic Information:

  VIRBase ID:  

HHID00011044

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          ZCCHC3:  NM_033089     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	ZCCHC3
miRBase Accession/Entrez ID	MIMAT0004588	85364
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C20orf99

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZCCHC3	chr20:278137-278138(+) m6A 5'UTR       25456834//24981863 chr20:278142-278143(+) m6A 5'UTR       25456834//24981863 chr20:278377-278378(+) m1A CDS       26863196//26863410 chr20:278480-278481(+) m6A CDS       24209618//25456834//24981863//22575960//22608085 chr20:278555-278556(+) m6A CDS       24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr20:278599-278600(+) m1A CDS       26863196 chr20:278774-278775(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:278816-278817(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:278939-278940(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:278951-278952(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:279032-279033(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr20:279109-279110(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr20:279229-279230(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr20:279253-279254(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr20:279281-279282(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr20:279366-279367(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr20:279442-279443(+) m6A 3'UTR       24284625//24209618//24981863 chr20:279466-279467(+) m6A 3'UTR       24284625//24209618//24981863 chr20:279500-279501(+) m6A 3'UTR       24284625//24981863//26404942 chr20:279512-279513(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:279549-279550(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:279560-279561(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:279582-279583(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:279648-279649(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:279892-279893(+) m6A 3'UTR       24284625//24981863//22608085 chr20:279996-279997(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:280083-280084(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:280162-280163(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:280180-280181(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:280209-280210(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr20:280481-280482(+) m6A 3'UTR       24284625//26404942 chr20:280488-280489(+) m6A 3'UTR       24284625//26404942 chr20:280667-280668(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	ZCCHC3	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: ZCCHC3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).