Detail Information

Basic Information:


  VIRBase ID:  

HHID00010976

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           TXNDC5:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p TXNDC5
miRBase
Accession/Entrez ID		 MIMAT0004588 81567
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ENDOPDI//ERP46//HCC-2//HCC2//PDIA15//STRF8//UNQ364

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TXNDC5
chr6:7882611-7882612(-) m6A 3'UTR//exon       24981863//26404942
chr6:7882658-7882659(-) m6A 3'UTR//exon       24981863//26404942
chr6:7882867-7882868(-) m6A 3'UTR//exon       26404942//22575960
chr6:7883049-7883050(-) m6A 3'UTR//exon       24284625//24981863//26404942//22575960//22608085
chr6:7883083-7883084(-) m6A 3'UTR//exon       24284625//24981863//26404942//22575960//22608085
chr6:7883149-7883150(-) m6A 3'UTR//exon       24284625//24981863
chr6:7883267-7883268(-) m6A 3'UTR//exon       24284625
chr6:7883373-7883374(-) m6A 3'UTR//exon       24284625//24981863//26404942//22575960
chr6:7883382-7883383(-) m6A CDS//exon       24284625//24981863//26404942//22575960
chr6:7883428-7883429(-) m6A CDS//exon       24284625//24981863//26404942//22575960
chr6:7884628-7884629(-) m6A CDS//exon       24284625//22575960
chr6:7884681-7884682(-) m6A CDS//exon       22575960
chr6:7884704-7884705(-) m6A CDS//exon       22575960
chr6:7888990-7888991(-) m6A CDS//exon       24981863//26404942//27773536//22575960
chr6:7889005-7889006(-) m6A CDS//exon       24981863//26404942//27773536//22575960
chr6:7889113-7889114(-) m6A exon//intron       24981863//26404942//27773536//22575960
chr6:7889125-7889126(-) m6A exon//intron       24981863//26404942//27773536//22575960
chr6:7889184-7889185(-) m6A exon//intron       27773536
chr6:7889437-7889438(-) m6A exon//intron       24284625
chr6:7889453-7889454(-) m6A exon//intron       24284625
chr6:7889459-7889460(-) m6A exon//intron       24284625
chr6:7889776-7889777(-) m6A CDS       27773536//22575960//22608085
chr6:7889790-7889791(-) m6A CDS       27773536//22575960
chr6:7891870-7891871(-) m6A CDS       22575960
chr6:7891880-7891881(-) m6A CDS       22575960
chr6:7895414-7895415(-) m6A CDS//exon       27773535//22575960
chr6:7898846-7898847(-) Gm intron       -
chr6:7899828-7899829(-) m6A CDS//exon       27773535//22575960
chr6:7899842-7899843(-) m6A CDS//exon       27773535//22575960
chr6:7899852-7899853(-) m6A CDS//exon       27773535//22575960
chr6:7899860-7899861(-) m6A CDS//exon       27773535//22575960
chr6:7899957-7899958(-) m6A exon//intron       27773535
chr6:7904860-7904861(-) m6A CDS       26404942//27773535//22575960
chr6:7904898-7904899(-) Cm 5'UTR//CDS       -
chr6:7904908-7904909(-) m6A 5'UTR//CDS       26404942//27773535//22575960
chr6:7904949-7904950(-) m6A 5'UTR//CDS       24284625//24209618//27773535//22575960
chr6:7910054-7910055(-) m6A 5'UTR//intron       24284625//24209618//22575960
chr6:7910102-7910103(-) m6A 5'UTR//intron       24284625//24209618//27773536
chr6:7910197-7910198(-) m6A 5'UTR//intron       24209618//27773536
chr6:7910833-7910834(-) m6A CDS       24284625//24209618//27371828//27773536//22575960
chr6:7910838-7910839(-) m6A CDS       24284625//24209618//27371828//27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
TXNDC5
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|HeLa-S3 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: TXNDC5

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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