Detail Information

Basic Information:


  VIRBase ID:  

HHID00010963

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           FAM214B:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p FAM214B
miRBase
Accession/Entrez ID		 MIMAT0004588 80256
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - KIAA1539

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase FAM214B
chr9:35104329-35104330(-) m6A 3'UTR       27773535
chr9:35104373-35104374(-) m6A 3'UTR       27773535
chr9:35104491-35104492(-) m6A 3'UTR       27773535
chr9:35105132-35105133(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr9:35105142-35105143(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr9:35105156-35105157(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr9:35105201-35105202(-) m6A 3'UTR       24284625//24209618//24981863//27773535
chr9:35105271-35105272(-) m6A CDS       24284625//24209618//24981863//27773535
chr9:35105290-35105291(-) m6A CDS       24284625//24209618//24981863//27773535
chr9:35105792-35105793(-) m6A CDS       27773535
chr9:35105832-35105833(-) m6A CDS       27773535
chr9:35105989-35105990(-) m6A CDS       27773535
chr9:35107770-35107771(-) m6A CDS//intron       24284625//24981863//27371828
chr9:35107795-35107796(-) m6A CDS//intron       24284625//24981863//27371828
chr9:35107862-35107863(-) m6A CDS//intron       24284625//25456834//24981863//27371828
chr9:35107890-35107891(-) m6A CDS//intron       24284625//25456834//24981863//27371828
chr9:35107941-35107942(-) m6A CDS//intron       24284625//25456834//24981863//27371828
chr9:35107953-35107954(-) m6A CDS//intron       24284625//25456834//24981863//27773535//27371828
chr9:35107986-35107987(-) m6A CDS//intron       24284625//25456834//24981863//27773535//27371828
chr9:35108001-35108002(-) m6A CDS//intron       25456834//24981863//27773535//27371828
chr9:35108663-35108664(-) m6A 5'UTR//exon       24284625//24209618//27371828
chr9:35111332-35111333(-) m6A 5'UTR//intron       24209618
chr9:35111345-35111346(-) m6A 5'UTR//intron       24209618
chr9:35111353-35111354(-) m6A 5'UTR//intron       24209618
chr9:35111428-35111429(-) m6A 5'UTR//intron       -
chr9:35115687-35115688(-) m6A 5'UTR//exon//intron       24284625//24981863//27371828
chr9:35115734-35115735(-) m6A 5'UTR//exon//intron       24284625//24981863//27371828
chr9:35115775-35115776(-) m1A 5'UTR//exon//intron       26863196
chr9:35115807-35115808(-) m6A 5'UTR//exon//intron       24284625//24981863//27371828
chr9:35115816-35115817(-) m6A 5'UTR//exon//intron       24284625//24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
FAM214B
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: FAM214B

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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