Detail Information

Basic Information:


  VIRBase ID:  

HHID00010959

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           MYCT1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p MYCT1
miRBase
Accession/Entrez ID		 MIMAT0004588 80177
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - MTLC

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MYCT1
chr6:153026380(+) A-I      intronic
chr6:153027821(+) A-I      intronic
chr6:153027771(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MYCT1
chr6:153043046-153043047(+) m6A CDS//intron       24981863
chr6:153043132-153043133(+) m6A CDS//intron       24981863
chr6:153043217-153043218(+) m6A CDS//intron       -
chr6:153043459-153043460(+) m6A 3'UTR//intron       -
chr6:153043508-153043509(+) m6A 3'UTR//intron       -
chr6:153043527-153043528(+) m6A 3'UTR//intron       -
chr6:153043542-153043543(+) m6A 3'UTR//intron       -
chr6:153043557-153043558(+) m6A 3'UTR//intron       -
chr6:153043893-153043894(+) m6A 3'UTR//intron       -
chr6:153043943-153043944(+) m6A 3'UTR       24209618//24981863
chr6:153044009-153044010(+) m6A 3'UTR       24209618//24981863
chr6:153044098-153044099(+) m6A 3'UTR       24209618//24981863
chr6:153044106-153044107(+) m6A 3'UTR       24209618//24981863
chr6:153044202-153044203(+) m6A 3'UTR       24209618//24981863
chr6:153044209-153044210(+) m6A 3'UTR       24209618//24981863
chr6:153044252-153044253(+) m6A 3'UTR       24209618//24981863
chr6:153044267-153044268(+) m6A 3'UTR       24209618//24981863
chr6:153044272-153044273(+) m6A 3'UTR       24209618//24981863
chr6:153044322-153044323(+) m6A 3'UTR       24209618//24981863
chr6:153044476-153044477(+) m6A 3'UTR       -
chr6:153044494-153044495(+) m6A 3'UTR       -
chr6:153044537-153044538(+) m6A 3'UTR       -
chr6:153044597-153044598(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
MYCT1
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: MYCT1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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