Detail Information

Basic Information:


  VIRBase ID:  

HHID00010946

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           PYROXD1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p PYROXD1
miRBase
Accession/Entrez ID		 MIMAT0004588 79912
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - MFM8

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PYROXD1
chr12:21593918(+) A-I      intronic
chr12:21592469(+) A-I      intronic
chr12:21600733(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PYROXD1
chr12:21603082(+) G-A intron -    22484847
chr12:21602804(+) T-C intron -    22484847
chr12:21616574(+) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PYROXD1
chr12:21590644-21590645(+) m6A 5'UTR       24981863
chr12:21608207-21608208(+) m6A 3'UTR//CDS//exon       24981863
chr12:21608986-21608987(+) m6A 3'UTR//CDS//exon       24981863
chr12:21621577-21621578(+) m6A 3'UTR//CDS//exon       24981863//22608085
chr12:21621592-21621593(+) m6A 3'UTR//CDS//exon       24981863//22608085
chr12:21621602-21621603(+) m6A 3'UTR//CDS//exon       24981863//22608085
chr12:21621614-21621615(+) m6A 3'UTR//CDS//exon       24981863//22608085
chr12:21621833-21621834(+) m6A 3'UTR       24981863
chr12:21621944-21621945(+) m6A 3'UTR       27773535
chr12:21622023-21622024(+) m6A 3'UTR       27773535
chr12:21622029-21622030(+) m6A 3'UTR       27773535
chr12:21622072-21622073(+) m6A 3'UTR       27773535
chr12:21622243-21622244(+) m6A 3'UTR       27773535
chr12:21622277-21622278(+) m6A 3'UTR       27773535
chr12:21622288-21622289(+) m6A 3'UTR       27773535
chr12:21622370-21622371(+) m6A 3'UTR       27773535
chr12:21622413-21622414(+) m6A 3'UTR       27773535
chr12:21622456-21622457(+) m6A 3'UTR       27773535
chr12:21622589-21622590(+) m6A 3'UTR       27773535
chr12:21622600-21622601(+) m6A 3'UTR       27773535
chr12:21622679-21622680(+) m6A 3'UTR       27773535
chr12:21622722-21622723(+) m6A 3'UTR       27773535
chr12:21622866-21622867(+) m6A 3'UTR       27773535
chr12:21622965-21622966(+) m6A 3'UTR       27773535
chr12:21623050-21623051(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
PYROXD1
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: PYROXD1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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