Detail Information

Basic Information:


  VIRBase ID:  

HHID00010926

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           SUV39H2:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p SUV39H2
miRBase
Accession/Entrez ID		 MIMAT0004588 79723
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - KMT1B

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SUV39H2
chr10:14932533(+) A-I      intronic
chr10:14925584(+) A-I      intronic
chr10:14932570(+) A-I      intronic
chr10:14925449(+) A-I      intronic
chr10:14937377(+) A-I      intronic
chr10:14925583(+) A-I      intronic
chr10:14925448(+) A-I      intronic
chr10:14932583(+) A-I      intronic
chr10:14924996(+) A-I      intronic
chr10:14946157(+) A-I      3'UTR

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SUV39H2
chr10:14920856-14920857(+) m6A 5'UTR       24981863//22608085
chr10:14923600-14923601(+) m6A 5'UTR//CDS//intron       27773535
chr10:14938903-14938904(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085
chr10:14939007-14939008(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr10:14939018-14939019(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr10:14939026-14939027(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr10:14939062-14939063(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr10:14939095-14939096(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr10:14939169-14939170(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22575960//22608085
chr10:14939194-14939195(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22575960//22608085
chr10:14939310-14939311(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22575960//22608085
chr10:14939435-14939436(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//22608085
chr10:14939465-14939466(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//22608085
chr10:14941569-14941570(+) m6A 3'UTR//CDS       24209618//24981863//22608085
chr10:14941613-14941614(+) m6A 3'UTR//CDS       24209618//22608085
chr10:14944587-14944588(+) m6A 3'UTR       22608085
chr10:14944638-14944639(+) m6A 3'UTR       22608085
chr10:14945122-14945123(+) m6A 3'UTR       22608085
chr10:14945147-14945148(+) m6A 3'UTR       22608085
chr10:14945165-14945166(+) m6A 3'UTR       22608085
chr10:14945249-14945250(+) m6A 3'UTR       22608085
chr10:14945262-14945263(+) m6A 3'UTR       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
SUV39H2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: SUV39H2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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