Detail Information

Basic Information:


  VIRBase ID:  

HHID00010897

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           DBNDD1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p DBNDD1
miRBase
Accession/Entrez ID		 MIMAT0004588 79007
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DBNDD1
chr16:90079113(-) A-I      intronic
chr16:90080729(-) A-I      intronic
chr16:90081337(-) A-I      intronic
chr16:90078979(-) A-I      intronic
chr16:90079537(-) A-I      intronic
chr16:90079250(-) A-I      intronic
chr16:90083781(-) A-I      intronic
chr16:90079006(-) A-I      intronic
chr16:90078989(-) A-I      intronic
chr16:90084243(-) A-I      intronic
chr16:90073039(-) A-I      intronic
chr16:90078727(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DBNDD1
chr16:90071489-90071490(-) m6A 3'UTR//exon       24284625//27773535
chr16:90071609-90071610(-) m6A 3'UTR//exon       24284625//27773535
chr16:90071885-90071886(-) m6A 3'UTR//exon       24284625//27773535
chr16:90072017-90072018(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//22608085
chr16:90072029-90072030(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//22608085
chr16:90072046-90072047(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//22608085
chr16:90072073-90072074(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//22608085
chr16:90072108-90072109(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//22608085
chr16:90072242-90072243(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22608085
chr16:90072325-90072326(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085
chr16:90072353-90072354(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22608085
chr16:90072426-90072427(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22608085
chr16:90072520-90072521(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr16:90072541-90072542(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr16:90072584-90072585(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr16:90072663-90072664(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22608085
chr16:90072699-90072700(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr16:90072741-90072742(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr16:90072746-90072747(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr16:90072779-90072780(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr16:90072846-90072847(-) m6A CDS//exon       24284625//25456834//24981863//27371828//27773536//22608085
chr16:90073227-90073228(-) m6A exon//intron       -
chr16:90073302-90073303(-) m6A exon//intron       -
chr16:90073346-90073347(-) m6A exon//intron       -
chr16:90073390-90073391(-) m6A exon//intron       -
chr16:90073436-90073437(-) m6A exon//intron       -
chr16:90075214-90075215(-) m6A 3'UTR//CDS//exon       24284625//27773536
chr16:90075256-90075257(-) m6A 3'UTR//CDS//exon       24284625//27773536
chr16:90075283-90075284(-) m6A 3'UTR//CDS//exon       27773536
chr16:90075774-90075775(-) m6A 3'UTR//CDS       24284625
chr16:90075781-90075782(-) m6A 3'UTR//CDS       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
DBNDD1
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus K562 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: DBNDD1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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