Basic Information:

  VIRBase ID:  

HHID00010880

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          MFSD14A:  NM_033055     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	MFSD14A
miRBase Accession/Entrez ID	MIMAT0004588	64645
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HIAT1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MFSD14A	chr1:100516483(+) A-I      intronic chr1:100542990(+) A-I      intronic chr1:100540363(+) A-I      intronic chr1:100540343(+) A-I      intronic chr1:100540341(+) A-I      intronic chr1:100540340(+) A-I      intronic chr1:100540320(+) A-I      intronic chr1:100516512(+) A-I      intronic chr1:100516489(+) A-I      intronic chr1:100507392(+) A-I      intronic chr1:100507382(+) A-I      intronic chr1:100541364(+) A-I      intronic chr1:100508305(+) A-I      intronic chr1:100539916(+) A-I      intronic chr1:100540014(+) A-I      intronic chr1:100532900(+) A-I      intronic chr1:100541376(+) A-I      intronic chr1:100532942(+) A-I      intronic chr1:100533105(+) A-I      intronic chr1:100533286(+) A-I      intronic chr1:100540004(+) A-I      intronic chr1:100541314(+) A-I      intronic chr1:100541309(+) A-I      intronic chr1:100540396(+) A-I      intronic chr1:100539954(+) A-I      intronic chr1:100534319(+) A-I      intronic chr1:100540381(+) A-I      intronic chr1:100540282(+) A-I      intronic chr1:100506081(+) A-I      intronic chr1:100506146(+) A-I      intronic chr1:100507225(+) A-I      intronic chr1:100507241(+) A-I      intronic chr1:100540268(+) A-I      intronic chr1:100534337(+) A-I      intronic chr1:100507281(+) A-I      intronic chr1:100507386(+) A-I      intronic chr1:100539875(+) A-I      intronic chr1:100516542(+) A-I      intronic chr1:100539876(+) A-I      intronic chr1:100507469(+) A-I      intronic chr1:100541399(+) A-I      intronic chr1:100508238(+) A-I      intronic chr1:100523076(+) A-I      intronic chr1:100529166(+) A-I      intronic chr1:100529170(+) A-I      intronic chr1:100541496(+) A-I      intronic chr1:100508325(+) A-I      intronic chr1:100516788(+) A-I      intronic chr1:100529267(+) A-I      intronic chr1:100508276(+) A-I      intronic chr1:100529862(+) A-I      intronic chr1:100523091(+) A-I      intronic chr1:100532290(+) A-I      intronic chr1:100516601(+) A-I      intronic chr1:100532464(+) A-I      intronic chr1:100529717(+) A-I      intronic chr1:100532831(+) A-I      intronic chr1:100507395(+) A-I      intronic chr1:100507359(+) A-I      intronic chr1:100532398(+) A-I      intronic chr1:100540015(+) A-I      intronic chr1:100523153(+) A-I      intronic chr1:100529151(+) A-I      intronic chr1:100529798(+) A-I      intronic chr1:100541400(+) A-I      intronic chr1:100522980(+) A-I      intronic chr1:100522972(+) A-I      intronic chr1:100508303(+) A-I      intronic chr1:100506134(+) A-I      intronic chr1:100508220(+) A-I      intronic chr1:100532291(+) A-I      intronic chr1:100530664(+) A-I      intronic chr1:100540050(+) A-I      intronic chr1:100506033(+) A-I      intronic chr1:100533176(+) A-I      intronic chr1:100507360(+) A-I      intronic chr1:100541454(+) A-I      intronic chr1:100507330(+) A-I      intronic chr1:100541469(+) A-I      intronic chr1:100540281(+) A-I      intronic chr1:100507337(+) A-I      intronic chr1:100519697(+) A-I      intronic chr1:100519791(+) A-I      intronic chr1:100508437(+) A-I      intronic chr1:100522051(+) A-I      intronic chr1:100529947(+) A-I      intronic chr1:100507425(+) A-I      intronic chr1:100530665(+) A-I      intronic chr1:100507327(+) A-I      intronic chr1:100507435(+) A-I      intronic chr1:100516530(+) A-I      intronic chr1:100522116(+) A-I      intronic chr1:100506278(+) A-I      intronic chr1:100508240(+) A-I      intronic chr1:100508395(+) A-I      intronic chr1:100521492(+) A-I      intronic chr1:100508293(+) A-I      intronic chr1:100544761(+) A-I      intronic chr1:100506117(+) A-I      intronic chr1:100506220(+) A-I      intronic chr1:100508349(+) A-I      intronic chr1:100508268(+) A-I      intronic chr1:100540286(+) A-I      intronic chr1:100507224(+) A-I      intronic chr1:100541374(+) A-I      intronic chr1:100507208(+) A-I      intronic chr1:100516462(+) A-I      intronic chr1:100508281(+) A-I      intronic chr1:100507255(+) A-I      intronic chr1:100522115(+) A-I      intronic chr1:100516463(+) A-I      intronic chr1:100508375(+) A-I      intronic chr1:100533222(+) A-I      intronic chr1:100539873(+) A-I      intronic chr1:100541486(+) A-I      intronic chr1:100529888(+) A-I      intronic chr1:100507421(+) A-I      intronic chr1:100519698(+) A-I      intronic chr1:100521378(+) A-I      intronic chr1:100530691(+) A-I      intronic chr1:100522118(+) A-I      intronic chr1:100516520(+) A-I      intronic chr1:100508346(+) A-I      intronic chr1:100529890(+) A-I      intronic chr1:100507329(+) A-I      intronic chr1:100516490(+) A-I      intronic chr1:100507369(+) A-I      intronic chr1:100507333(+) A-I      intronic chr1:100522014(+) A-I      intronic chr1:100508267(+) A-I      intronic chr1:100519653(+) A-I      intronic chr1:100533305(+) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	MFSD14A	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: MFSD14A

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).