Detail Information

Basic Information:


  VIRBase ID:  

HHID00010865

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           RRAGC:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p RRAGC
miRBase
Accession/Entrez ID		 MIMAT0004588 64121
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - GTR2//RAGC//TIB929

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RRAGC
chr1:39307205(-) A-I      intronic
chr1:39307180(-) A-I      intronic
chr1:39307131(-) A-I      intronic
chr1:39307232(-) A-I      intronic
chr1:39319816(-) A-I      intronic
chr1:39319770(-) A-I      intronic
chr1:39319271(-) A-I      intronic
chr1:39319261(-) A-I      intronic
chr1:39320013(-) A-I      intronic
chr1:39320032(-) A-I      intronic
chr1:39314436(-) A-I      intronic
chr1:39316104(-) A-I      intronic
chr1:39314485(-) A-I      intronic
chr1:39314398(-) A-I      intronic
chr1:39313064(-) A-I      ncRNA
chr1:39319297(-) A-I      intronic
chr1:39319406(-) A-I      intronic
chr1:39314928(-) A-I      intronic
chr1:39315028(-) A-I      intronic
chr1:39319307(-) A-I      intronic
chr1:39307174(-) A-I      intronic
chr1:39319904(-) A-I      intronic
chr1:39305698(-) A-I      intronic
chr1:39307688(-) A-I      intronic
chr1:39314469(-) A-I      intronic
chr1:39307160(-) A-I      intronic
chr1:39319192(-) A-I      intronic
chr1:39319356(-) A-I      intronic
chr1:39307755(-) A-I      intronic
chr1:39313078(-) A-I      ncRNA
chr1:39313643(-) A-I      ncRNA
chr1:39314453(-) A-I      intronic
chr1:39307820(-) A-I      intronic
chr1:39319336(-) A-I      intronic
chr1:39314544(-) A-I      intronic
chr1:39314948(-) A-I      intronic
chr1:39320016(-) A-I      intronic
chr1:39307206(-) A-I      intronic
chr1:39319934(-) A-I      intronic
chr1:39316617(-) A-I      intronic
chr1:39319310(-) A-I      intronic
chr1:39316598(-) A-I      intronic
chr1:39319836(-) A-I      intronic
chr1:39319201(-) A-I      intronic
chr1:39307117(-) A-I      intronic
chr1:39314547(-) A-I      intronic
chr1:39307213(-) A-I      intronic
chr1:39307240(-) A-I      intronic
chr1:39316637(-) A-I      intronic
chr1:39319200(-) A-I      intronic
chr1:39319357(-) A-I      intronic
chr1:39319380(-) A-I      intronic
chr1:39307686(-) A-I      intronic
chr1:39314866(-) A-I      intronic
chr1:39307682(-) A-I      intronic
chr1:39319983(-) A-I      intronic
chr1:39307204(-) A-I      intronic
chr1:39307176(-) A-I      intronic
chr1:39315021(-) A-I      intronic
chr1:39319878(-) A-I      intronic
chr1:39316541(-) A-I      intronic
chr1:39307233(-) A-I      intronic
chr1:39307200(-) A-I      intronic
chr1:39314967(-) A-I      intronic
chr1:39319252(-) A-I      intronic
chr1:39307255(-) A-I      intronic
chr1:39307644(-) A-I      intronic
chr1:39307763(-) A-I      intronic
chr1:39319255(-) A-I      intronic
chr1:39319845(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED RRAGC
chr1:39307117(-) A-G intron -    22484847
chr1:39314866(-) A-G intron -    22484847
chr1:39314948(-) A-G intron -    22484847
chr1:39315021(-) A-G intron -    22484847
chr1:39315028(-) A-G intron -    22484847
chr1:39319192(-) A-G intron -    22484847
chr1:39319200(-) A-G intron -    22484847
chr1:39319201(-) A-G intron -    22484847
chr1:39319307(-) A-G intron -    22484847
chr1:39319310(-) A-G intron -    22484847
chr1:39319380(-) A-G intron -    22484847
chr1:39319406(-) A-G intron -    22484847
chr1:39319836(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RRAGC
chr1:39303911-39303912(-) m6A 3'UTR       24981863
chr1:39303967-39303968(-) m6A 3'UTR       24981863
chr1:39304313-39304314(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr1:39304385-39304386(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr1:39304442-39304443(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr1:39304583-39304584(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr1:39304684-39304685(-) m6A 3'UTR       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr1:39304703-39304704(-) m6A 3'UTR       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr1:39304737-39304738(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr1:39304753-39304754(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr1:39304811-39304812(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr1:39304853-39304854(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr1:39304928-39304929(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:39304985-39304986(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:39304993-39304994(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:39305074-39305075(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr1:39305105-39305106(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr1:39305152-39305153(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr1:39305283-39305284(-) m6A CDS//exon       24209618//22608085
chr1:39321439-39321440(-) m6A CDS//exon       27773535
chr1:39321449-39321450(-) m6A CDS//exon       27773535
chr1:39321511-39321512(-) m6A CDS//exon       27773535
chr1:39321552-39321553(-) m6A CDS//exon       27773535
chr1:39322390-39322391(-) m6A exon//intron       27773535
chr1:39322498-39322499(-) m6A exon//intron       24284625//24981863//27773535
chr1:39322582-39322583(-) m6A CDS       24284625//24209618//24981863//27773535
chr1:39322626-39322627(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr1:39322723-39322724(-) m6A CDS       24284625//24209618//27773535
chr1:39325114-39325115(-) m6A CDS       24209618
chr1:39325244-39325245(-) m6A CDS       24209618//25456834//27371828
chr1:39325388-39325389(-) m6A 5'UTR       24209618

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
RRAGC
Exosome Blood     -
Nucleolus K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: RRAGC

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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