Detail Information

Basic Information:


  VIRBase ID:  

HHID00010861

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           MRPL17:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p MRPL17
miRBase
Accession/Entrez ID		 MIMAT0004588 63875
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - L17mt//LIP2//MRP-L17//MRP-L26//RPL17L//RPML26

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MRPL17
chr11:6702406-6702407(-) m6A 3'UTR//exon       24981863
chr11:6703224-6703225(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr11:6703245-6703246(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr11:6703269-6703270(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr11:6703362-6703363(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr11:6703412-6703413(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr11:6703439-6703440(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr11:6703460-6703461(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr11:6703575-6703576(-) m6A CDS//exon       24209618//26404942//27773535//27773536//22575960
chr11:6704020-6704021(-) m6A CDS//exon//intron       27773535//27371828//27773536
chr11:6704190-6704191(-) m6A exon//intron       25456834//27371828//22608085
chr11:6704219-6704220(-) m6A exon//intron       25456834//27371828//22608085
chr11:6704231-6704232(-) m6A exon//intron       25456834//27371828//22608085
chr11:6704259-6704260(-) m6A exon//intron       25456834//27371828//27773536//22608085
chr11:6704272-6704273(-) m6A exon//intron       25456834//27371828//27773536//22608085
chr11:6704278-6704279(-) m6A exon//intron       25456834//27371828//27773536//22608085
chr11:6704435-6704436(-) m6A CDS//exon       24284625//24981863//27773535//27371828//27773536//22575960
chr11:6704528-6704529(-) m6A 5'UTR       24284625//24981863//26404942//27371828//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
MRPL17
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: MRPL17

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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