Detail Information

Basic Information:


  VIRBase ID:  

HHID00010853

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           CWC22:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p CWC22
miRBase
Accession/Entrez ID		 MIMAT0004588 57703
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EIF4GL//fSAPb//NCM

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CWC22
chr2:180810955(-) A-I      intronic
chr2:180810702(-) A-I      intronic
chr2:180870216(-) A-I      intronic
chr2:180870140(-) A-I      intronic
chr2:180841862(-) A-I      intronic
chr2:180841856(-) A-I      intronic
chr2:180841637(-) A-I      intronic
chr2:180811116(-) A-I      intronic
chr2:180870221(-) A-I      intronic
chr2:180810817(-) A-I      intronic
chr2:180811029(-) A-I      intronic
chr2:180811102(-) A-I      intronic
chr2:180810747(-) A-I      intronic
chr2:180810956(-) A-I      intronic
chr2:180839653(-) A-I      intronic
chr2:180841846(-) A-I      intronic
chr2:180810706(-) A-I      intronic
chr2:180839713(-) A-I      intronic
chr2:180811056(-) A-I      intronic
chr2:180811030(-) A-I      intronic
chr2:180811083(-) A-I      intronic
chr2:180810989(-) A-I      intronic
chr2:180810777(-) A-I      intronic
chr2:180810847(-) A-I      intronic
chr2:180811156(-) A-I      intronic
chr2:180839724(-) A-I      intronic
chr2:180839643(-) A-I      intronic
chr2:180839594(-) A-I      intronic
chr2:180810787(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CWC22
chr2:180810842(-) A-G intron -    22484847
chr2:180811056(-) A-G intron -    22484847
chr2:180811156(-) A-G intron -    22484847
chr2:180841846(-) A-G intron -    22484847
chr2:180870191(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CWC22
chr2:180809664-180809665(-) m6A 3'UTR       27773535//22608085
chr2:180809785-180809786(-) m6A 3'UTR       24209618//25456834//24981863//27773535//27371828//22608085
chr2:180809809-180809810(-) m6A 3'UTR       24209618//25456834//24981863//27773535//27371828//22608085
chr2:180809831-180809832(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr2:180809836-180809837(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr2:180809864-180809865(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr2:180809892-180809893(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr2:180809921-180809922(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr2:180810057-180810058(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085
chr2:180810168-180810169(-) m6A CDS       24284625//24981863//27773535//22608085
chr2:180810222-180810223(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr2:180810284-180810285(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr2:180810310-180810311(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828//22608085
chr2:180810316-180810317(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828//22608085
chr2:180810332-180810333(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828//22608085
chr2:180810338-180810339(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828//22608085
chr2:180810353-180810354(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828//22608085
chr2:180810367-180810368(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828//22608085
chr2:180810375-180810376(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828//22608085
chr2:180810409-180810410(-) m6A CDS       24284625//25456834//24981863//27773535//22608085
chr2:180810419-180810420(-) m6A CDS       24284625//24981863//27773535//22608085
chr2:180819715-180819716(-) m6A CDS       27773535
chr2:180819755-180819756(-) m6A CDS       27773535
chr2:180823750-180823751(-) m6A CDS       27773535
chr2:180829328-180829329(-) m6A CDS       24981863//27773535
chr2:180830672-180830673(-) m6A CDS       24981863//27773535
chr2:180830678-180830679(-) m6A CDS       24981863//27773535
chr2:180835397-180835398(-) Y CDS       26075521
chr2:180846481-180846482(-) m6A CDS       24981863
chr2:180846498-180846499(-) m6A CDS       24981863//27773535
chr2:180846594-180846595(-) m6A CDS       24981863//27773535
chr2:180846629-180846630(-) m6A CDS       24981863//27773535
chr2:180846637-180846638(-) m6A CDS       24981863//27773535
chr2:180846715-180846716(-) m6A CDS       24981863//27773535
chr2:180846721-180846722(-) m6A CDS       24981863//27773535
chr2:180851472-180851473(-) m6A CDS       24981863//27773535
chr2:180851522-180851523(-) m6A CDS       27773535
chr2:180853306-180853307(-) m6A CDS       27773535
chr2:180853321-180853322(-) m6A CDS       27773535
chr2:180853342-180853343(-) m6A CDS       27773535
chr2:180858085-180858086(-) m6A 5'UTR       24981863//27773535
chr2:180858114-180858115(-) m6A 5'UTR       24981863//27773535
chr2:180858154-180858155(-) m6A 5'UTR       24981863//27773535
chr2:180858167-180858168(-) m6A 5'UTR       24981863//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
CWC22
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: CWC22

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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