Basic Information:

  VIRBase ID:  

HHID00010765

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          MCM10:  NM_018518     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	MCM10
miRBase Accession/Entrez ID	MIMAT0004588	55388
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CNA43//DNA43//PRO2249

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MCM10	chr10:13231532(+) A-I      intronic chr10:13231597(+) A-I      intronic chr10:13232422(+) A-I      intronic chr10:13232428(+) A-I      intronic chr10:13232505(+) A-I      intronic chr10:13232546(+) A-I      intronic chr10:13232564(+) A-I      intronic chr10:13231520(+) A-I      intronic chr10:13231512(+) A-I      intronic chr10:13231440(+) A-I      intronic chr10:13231403(+) A-I      intronic chr10:13216291(+) A-I      intronic chr10:13231557(+) A-I      intronic chr10:13231462(+) A-I      intronic chr10:13244272(+) A-I      intronic chr10:13228030(+) A-I      intronic chr10:13227886(+) A-I      intronic chr10:13220309(+) A-I      intronic chr10:13220147(+) A-I      intronic chr10:13217275(+) A-I      intronic chr10:13236461(+) A-I      intronic chr10:13205751(+) A-I      intronic chr10:13236466(+) A-I      intronic chr10:13244876(+) A-I      intronic chr10:13232468(+) A-I      intronic chr10:13232508(+) A-I      intronic chr10:13250129(+) A-I      intronic chr10:13244944(+) A-I      intronic chr10:13244164(+) A-I      intronic chr10:13244143(+) A-I      intronic chr10:13228036(+) A-I      intronic chr10:13241131(+) A-I      intronic chr10:13241105(+) A-I      intronic chr10:13250137(+) A-I      intronic chr10:13206904(+) A-I      intronic chr10:13245019(+) A-I      intronic chr10:13244109(+) A-I      intronic chr10:13241021(+) A-I      intronic chr10:13244112(+) A-I      intronic chr10:13227982(+) A-I      intronic chr10:13216243(+) A-I      intronic chr10:13232469(+) A-I      intronic chr10:13216242(+) A-I      intronic chr10:13219799(+) A-I      intronic chr10:13227976(+) A-I      intronic chr10:13217274(+) A-I      intronic chr10:13244945(+) A-I      intronic chr10:13217338(+) A-I      intronic chr10:13220163(+) A-I      intronic chr10:13250202(+) A-I      intronic chr10:13232668(+) A-I      intronic chr10:13217337(+) A-I      intronic chr10:13232570(+) A-I      intronic chr10:13205722(+) A-I      intronic chr10:13228753(+) A-I      intronic chr10:13232450(+) A-I      intronic chr10:13220152(+) A-I      intronic chr10:13219662(+) A-I      intronic chr10:13242999(+) A-I      intronic chr10:13242066(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MCM10	chr10:13244112(+) A-G intron -    22484847 chr10:13245019(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MCM10	chr10:13212930-13212931(+) m6A 5'UTR//CDS       - chr10:13213103-13213104(+) m6A 5'UTR//CDS       24981863//27773535//22608085 chr10:13213112-13213113(+) m6A 5'UTR//CDS       24981863//27773535//22608085 chr10:13213161-13213162(+) m6A CDS       24981863//22608085 chr10:13214743-13214744(+) m6A CDS       - chr10:13217575-13217576(+) m6A CDS       - chr10:13217613-13217614(+) m6A CDS       - chr10:13225043-13225044(+) m6A CDS       - chr10:13228244-13228245(+) Am CDS       - chr10:13234469-13234470(+) m6A CDS       24981863 chr10:13237235-13237236(+) m6A CDS//exon       - chr10:13237241-13237242(+) m6A CDS//exon       - chr10:13239670-13239671(+) m6A CDS//exon       24981863 chr10:13239680-13239681(+) m6A CDS//exon       24981863 chr10:13239696-13239697(+) m6A CDS//exon       24981863 chr10:13239704-13239705(+) m6A CDS//exon       24981863 chr10:13239713-13239714(+) m6A CDS//exon       24981863 chr10:13239746-13239747(+) m6A CDS//exon       24981863 chr10:13240728-13240729(+) m6A CDS//exon       24981863 chr10:13240785-13240786(+) m6A CDS//exon       24981863 chr10:13243470-13243471(+) m6A CDS//exon       24981863 chr10:13243493-13243494(+) m6A CDS//exon       24981863 chr10:13246248-13246249(+) m6A CDS//exon       24209618 chr10:13246321-13246322(+) m6A CDS//exon       24284625//24209618//22608085 chr10:13246339-13246340(+) m6A CDS//exon       24284625//24209618//24981863//22608085 chr10:13246351-13246352(+) m6A CDS//exon       24284625//24209618//24981863//22608085 chr10:13246496-13246497(+) m6A exon//intron       24284625//24209618//25456834//24981863//22608085 chr10:13251192-13251193(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr10:13251232-13251233(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr10:13251256-13251257(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:13251279-13251280(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:13251296-13251297(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:13251315-13251316(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:13251322-13251323(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:13251336-13251337(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:13251416-13251417(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr10:13251509-13251510(+) m6A 3'UTR       24209618//24981863//22608085 chr10:13251774-13251775(+) m6A 3'UTR       24981863//27773535 chr10:13251827-13251828(+) m6A 3'UTR       24981863//27773535 chr10:13251872-13251873(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	MCM10	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: MCM10

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).