Basic Information:

  VIRBase ID:  

HHID00010748

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          RPRD1A:  NM_001303412     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	RPRD1A
miRBase Accession/Entrez ID	MIMAT0004588	55197
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HsT3101//P15RS

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RPRD1A	chr18:33610336(-) A-I      intronic chr18:33610334(-) A-I      intronic chr18:33610329(-) A-I      intronic chr18:33610318(-) A-I      intronic chr18:33601901(-) A-I      intronic chr18:33601895(-) A-I      intronic chr18:33596383(-) A-I      intronic chr18:33596379(-) A-I      intronic chr18:33596363(-) A-I      intronic chr18:33578213(-) A-I      intronic chr18:33596355(-) A-I      intronic chr18:33596353(-) A-I      intronic chr18:33578267(-) A-I      intronic chr18:33595340(-) A-I      intronic chr18:33595353(-) A-I      intronic chr18:33634334(-) A-I      intronic chr18:33610338(-) A-I      intronic chr18:33604673(-) A-I      intronic chr18:33583725(-) A-I      intronic chr18:33584385(-) A-I      intronic chr18:33584413(-) A-I      intronic chr18:33584414(-) A-I      intronic chr18:33584421(-) A-I      intronic chr18:33584422(-) A-I      intronic chr18:33596318(-) A-I      intronic chr18:33578199(-) A-I      intronic chr18:33602879(-) A-I      intronic chr18:33610324(-) A-I      intronic chr18:33640284(-) A-I      intronic chr18:33639319(-) A-I      intronic chr18:33639277(-) A-I      intronic chr18:33637523(-) A-I      intronic chr18:33637522(-) A-I      intronic chr18:33637516(-) A-I      intronic chr18:33637480(-) A-I      intronic chr18:33637367(-) A-I      intronic chr18:33636961(-) A-I      intronic chr18:33636452(-) A-I      intronic chr18:33636389(-) A-I      intronic chr18:33636323(-) A-I      intronic chr18:33599128(-) A-I      intronic chr18:33598348(-) A-I      intronic chr18:33597262(-) A-I      intronic chr18:33597218(-) A-I      intronic chr18:33609829(-) A-I      intronic chr18:33596405(-) A-I      intronic chr18:33596389(-) A-I      intronic chr18:33596380(-) A-I      intronic chr18:33596302(-) A-I      intronic chr18:33596282(-) A-I      intronic chr18:33596278(-) A-I      intronic chr18:33595355(-) A-I      intronic chr18:33595352(-) A-I      intronic chr18:33595344(-) A-I      intronic chr18:33595343(-) A-I      intronic chr18:33595308(-) A-I      intronic chr18:33594630(-) A-I      intronic chr18:33594522(-) A-I      intronic chr18:33586453(-) A-I      intronic chr18:33586383(-) A-I      intronic chr18:33586358(-) A-I      intronic chr18:33586270(-) A-I      intronic chr18:33586257(-) A-I      intronic chr18:33585217(-) A-I      intronic chr18:33585207(-) A-I      intronic chr18:33585195(-) A-I      intronic chr18:33585106(-) A-I      intronic chr18:33585043(-) A-I      intronic chr18:33584860(-) A-I      intronic chr18:33584744(-) A-I      intronic chr18:33584398(-) A-I      intronic chr18:33584397(-) A-I      intronic chr18:33578273(-) A-I      intronic chr18:33578153(-) A-I      intronic chr18:33576937(-) A-I      intronic chr18:33576935(-) A-I      intronic chr18:33576927(-) A-I      intronic chr18:33576922(-) A-I      intronic chr18:33599139(-) A-I      intronic chr18:33599106(-) A-I      intronic chr18:33610282(-) A-I      intronic chr18:33610284(-) A-I      intronic chr18:33632729(-) A-I      intronic chr18:33632740(-) A-I      intronic chr18:33632742(-) A-I      intronic chr18:33632745(-) A-I      intronic chr18:33636285(-) A-I      intronic chr18:33578221(-) A-I      intronic chr18:33575294(-) A-I      intronic chr18:33609826(-) A-I      intronic chr18:33604225(-) A-I      intronic chr18:33604212(-) A-I      intronic chr18:33575311(-) A-I      intronic chr18:33575329(-) A-I      intronic chr18:33575425(-) A-I      intronic chr18:33610307(-) A-I      intronic chr18:33594508(-) A-I      intronic chr18:33599275(-) A-I      intronic chr18:33599273(-) A-I      intronic chr18:33599265(-) A-I      intronic chr18:33599248(-) A-I      intronic chr18:33599242(-) A-I      intronic chr18:33575520(-) A-I      intronic chr18:33576905(-) A-I      intronic chr18:33602817(-) A-I      intronic chr18:33610359(-) A-I      intronic chr18:33626612(-) A-I      intronic chr18:33601914(-) A-I      intronic chr18:33632722(-) A-I      intronic chr18:33599182(-) A-I      intronic chr18:33609987(-) A-I      intronic chr18:33629150(-) A-I      intronic chr18:33640213(-) A-I      intronic chr18:33597043(-) A-I      intronic chr18:33602809(-) A-I      intronic chr18:33584278(-) A-I      intronic chr18:33602890(-) A-I      intronic chr18:33632726(-) A-I      intronic chr18:33601770(-) A-I      intronic chr18:33596334(-) A-I      intronic chr18:33599728(-) A-I      intronic chr18:33597161(-) A-I      intronic chr18:33637071(-) A-I      intronic chr18:33596220(-) A-I      intronic chr18:33610256(-) A-I      intronic chr18:33597258(-) A-I      intronic chr18:33601877(-) A-I      intronic chr18:33599855(-) A-I      intronic chr18:33643304(-) A-I      intronic chr18:33584766(-) A-I      intronic chr18:33602842(-) A-I      intronic chr18:33599365(-) A-I      intronic chr18:33594702(-) A-I      intronic chr18:33599981(-) A-I      intronic chr18:33596368(-) A-I      intronic chr18:33596441(-) A-I      intronic chr18:33600733(-) A-I      intronic chr18:33602757(-) A-I      intronic chr18:33604238(-) A-I      intronic chr18:33639247(-) A-I      intronic chr18:33586348(-) A-I      intronic chr18:33602901(-) A-I      intronic chr18:33602669(-) A-I      intronic chr18:33597151(-) A-I      intronic chr18:33576671(-) A-I      intronic chr18:33599989(-) A-I      intronic chr18:33575338(-) A-I      intronic chr18:33596324(-) A-I      intronic chr18:33583840(-) A-I      intronic chr18:33628126(-) A-I      intronic chr18:33588296(-) A-I      intronic chr18:33645458(-) A-I      intronic chr18:33639238(-) A-I      intronic chr18:33638117(-) A-I      intronic chr18:33575366(-) A-I      intronic chr18:33584474(-) A-I      intronic chr18:33601842(-) A-I      intronic chr18:33576879(-) A-I      intronic chr18:33602825(-) A-I      intronic chr18:33584346(-) A-I      intronic chr18:33599260(-) A-I      intronic chr18:33598509(-) A-I      intronic chr18:33599342(-) A-I      intronic chr18:33595238(-) A-I      intronic chr18:33602708(-) A-I      intronic chr18:33601878(-) A-I      intronic chr18:33599881(-) A-I      intronic chr18:33596350(-) A-I      intronic chr18:33584417(-) A-I      intronic chr18:33626736(-) A-I      intronic chr18:33576848(-) A-I      intronic chr18:33597220(-) A-I      intronic chr18:33626722(-) A-I      intronic chr18:33576859(-) A-I      intronic chr18:33597242(-) A-I      intronic chr18:33599811(-) A-I      intronic chr18:33599951(-) A-I      intronic chr18:33594704(-) A-I      intronic chr18:33601791(-) A-I      intronic chr18:33586279(-) A-I      intronic chr18:33597144(-) A-I      intronic chr18:33595314(-) A-I      intronic chr18:33600763(-) A-I      intronic chr18:33643390(-) A-I      intronic chr18:33599751(-) A-I      intronic chr18:33597181(-) A-I      intronic chr18:33588463(-) A-I      intronic chr18:33599209(-) A-I      intronic chr18:33576894(-) A-I      intronic chr18:33596340(-) A-I      intronic chr18:33613001(-) A-I      intronic chr18:33598508(-) A-I      intronic chr18:33597211(-) A-I      intronic chr18:33583900(-) A-I      intronic chr18:33584310(-) A-I      intronic chr18:33599820(-) A-I      intronic chr18:33588417(-) A-I      intronic chr18:33584315(-) A-I      intronic chr18:33599343(-) A-I      intronic chr18:33595354(-) A-I      intronic chr18:33599280(-) A-I      intronic chr18:33602681(-) A-I      intronic chr18:33597107(-) A-I      intronic chr18:33575432(-) A-I      intronic chr18:33597257(-) A-I      intronic chr18:33602754(-) A-I      intronic chr18:33578239(-) A-I      intronic chr18:33610036(-) A-I      intronic chr18:33584783(-) A-I      intronic chr18:33604391(-) A-I      intronic chr18:33599239(-) A-I      intronic chr18:33588443(-) A-I      intronic chr18:33599251(-) A-I      intronic chr18:33602845(-) A-I      intronic chr18:33600739(-) A-I      intronic chr18:33584387(-) A-I      intronic chr18:33610185(-) A-I      intronic chr18:33600725(-) A-I      intronic chr18:33588035(-) A-I      intronic chr18:33575522(-) A-I      intronic chr18:33637544(-) A-I      intronic chr18:33598369(-) A-I      intronic chr18:33599800(-) A-I      intronic chr18:33595380(-) A-I      intronic chr18:33595446(-) A-I      intronic chr18:33595394(-) A-I      intronic chr18:33637386(-) A-I      intronic chr18:33588290(-) A-I      intronic chr18:33634344(-) A-I      intronic chr18:33598365(-) A-I      intronic chr18:33588323(-) A-I      intronic chr18:33588326(-) A-I      intronic chr18:33637571(-) A-I      intronic chr18:33637573(-) A-I      intronic chr18:33599167(-) A-I      intronic chr18:33578280(-) A-I      intronic chr18:33575393(-) A-I      intronic chr18:33584435(-) A-I      intronic chr18:33594512(-) A-I      intronic chr18:33637463(-) A-I      intronic chr18:33588020(-) A-I      intronic chr18:33610191(-) A-I      intronic chr18:33637561(-) A-I      intronic chr18:33576721(-) A-I      intronic chr18:33597124(-) A-I      intronic chr18:33600681(-) A-I      intronic chr18:33595358(-) A-I      intronic chr18:33602838(-) A-I      intronic chr18:33584709(-) A-I      intronic chr18:33576709(-) A-I      intronic chr18:33595369(-) A-I      intronic chr18:33602758(-) A-I      intronic chr18:33626677(-) A-I      intronic chr18:33584852(-) A-I      intronic chr18:33576737(-) A-I      intronic chr18:33578065(-) A-I      intronic chr18:33599921(-) A-I      intronic chr18:33597207(-) A-I      intronic chr18:33604356(-) A-I      intronic chr18:33576755(-) A-I      intronic chr18:33598401(-) A-I      intronic chr18:33637353(-) A-I      intronic chr18:33588439(-) A-I      intronic chr18:33600741(-) A-I      intronic chr18:33604242(-) A-I      intronic chr18:33601727(-) A-I      intronic chr18:33601869(-) A-I      intronic chr18:33640274(-) A-I      intronic chr18:33584473(-) A-I      intronic chr18:33632736(-) A-I      intronic chr18:33604374(-) A-I      intronic chr18:33598420(-) A-I      intronic chr18:33584382(-) A-I      intronic chr18:33637077(-) A-I      intronic chr18:33578245(-) A-I      intronic chr18:33604332(-) A-I      intronic chr18:33578238(-) A-I      intronic chr18:33604248(-) A-I      intronic chr18:33598375(-) A-I      intronic chr18:33597012(-) A-I      intronic chr18:33597217(-) A-I      intronic chr18:33595379(-) A-I      intronic chr18:33588427(-) A-I      intronic chr18:33584386(-) A-I      intronic chr18:33629003(-) A-I      intronic chr18:33576684(-) A-I      intronic chr18:33599831(-) A-I      intronic chr18:33610041(-) A-I      intronic chr18:33636523(-) A-I      intronic chr18:33599238(-) A-I      intronic chr18:33584391(-) A-I      intronic chr18:33597024(-) A-I      intronic chr18:33599891(-) A-I      intronic chr18:33601705(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RPRD1A	chr18:33575366(-) A-G intron -    22484847 chr18:33576879(-) A-G intron -    22484847 chr18:33583824(-) A-G intron -    22484847 chr18:33583900(-) A-G intron -    22484847 chr18:33584083(-) A-G intron -    22484847 chr18:33584346(-) A-G intron -    22484847 chr18:33584386(-) A-G intron -    22484847 chr18:33584741(-) A-G intron -    22484847 chr18:33584766(-) A-G intron -    22484847 chr18:33596441(-) A-G intron -    22484847 chr18:33599342(-) A-G intron -    22484847 chr18:33599343(-) A-G intron -    22484847 chr18:33602901(-) A-G intron -    22484847 chr18:33604391(-) A-G intron -    22484847 chr18:33604392(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RPRD1A	chr18:33564448-33564449(-) m6A 3'UTR       27773535 chr18:33572998-33572999(-) m6A 3'UTR//intron       24981863//22608085 chr18:33573013-33573014(-) m6A 3'UTR//intron       24981863//22608085 chr18:33573067-33573068(-) m6A 3'UTR       24284625//24981863//22608085 chr18:33573085-33573086(-) m6A 3'UTR       24284625//24981863//22608085 chr18:33573109-33573110(-) m6A 3'UTR       24284625//24981863//22608085 chr18:33573132-33573133(-) m6A CDS       24284625//24981863//22608085 chr18:33573189-33573190(-) m6A CDS       24284625//24981863//22575960//22608085 chr18:33573218-33573219(-) m6A CDS       24284625 chr18:33610779-33610780(-) m6A CDS       24981863 chr18:33610807-33610808(-) m6A CDS       24981863 chr18:33610833-33610834(-) m6A CDS       24981863 chr18:33610841-33610842(-) m6A CDS       24981863 chr18:33610963-33610964(-) m6A CDS       24981863 chr18:33610972-33610973(-) m6A CDS       24981863 chr18:33611055-33611056(-) m6A CDS       24981863 chr18:33613786-33613787(-) Y 3'UTR//CDS       26075521 chr18:33647262-33647263(-) m6A 5'UTR//CDS       27773536 chr18:33647294-33647295(-) m6A 5'UTR//CDS       27371828//27773536 chr18:33647333-33647334(-) m1A 5'UTR//CDS       26863196//26863410 chr18:33647421-33647422(-) m6A 5'UTR       24284625//24209618//24981863//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	RPRD1A	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: RPRD1A

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).