Detail Information

Basic Information:


  VIRBase ID:  

HHID00010708

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           TMCO1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p TMCO1
miRBase
Accession/Entrez ID		 MIMAT0004588 54499
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HP10122//PCIA3//PNAS-136//TMCC4

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMCO1
chr1:165700035(-) A-I      intronic
chr1:165705024(-) A-I      intronic
chr1:165700019(-) A-I      intronic
chr1:165700026(-) A-I      intronic
chr1:165714330(-) A-I      intronic
chr1:165714342(-) A-I      intronic
chr1:165714772(-) A-I      intronic
chr1:165724013(-) A-I      intronic
chr1:165724107(-) A-I      intronic
chr1:165726810(-) A-I      intronic
chr1:165698104(-) A-I      intronic
chr1:165698108(-) A-I      intronic
chr1:165733083(-) A-I      intronic
chr1:165698661(-) A-I      intronic
chr1:165730542(-) A-I      intronic
chr1:165698718(-) A-I      intronic
chr1:165698099(-) A-I      intronic
chr1:165698770(-) A-I      intronic
chr1:165697632(-) A-I      intronic
chr1:165699451(-) A-I      intronic
chr1:165727792(-) A-I      intronic
chr1:165700027(-) A-I      intronic
chr1:165700073(-) A-I      intronic
chr1:165700102(-) A-I      intronic
chr1:165702641(-) A-I      intronic
chr1:165703920(-) A-I      intronic
chr1:165697561(-) A-I      intronic
chr1:165727746(-) A-I      intronic
chr1:165727653(-) A-I      intronic
chr1:165727627(-) A-I      intronic
chr1:165703991(-) A-I      intronic
chr1:165726910(-) A-I      intronic
chr1:165704873(-) A-I      intronic
chr1:165727669(-) A-I      intronic
chr1:165705796(-) A-I      intronic
chr1:165726908(-) A-I      intronic
chr1:165705858(-) A-I      intronic
chr1:165706306(-) A-I      intronic
chr1:165726875(-) A-I      intronic
chr1:165726873(-) A-I      intronic
chr1:165709241(-) A-I      intronic
chr1:165709308(-) A-I      intronic
chr1:165713944(-) A-I      intronic
chr1:165713993(-) A-I      intronic
chr1:165709340(-) A-I      intronic
chr1:165727671(-) A-I      intronic
chr1:165706068(-) A-I      intronic
chr1:165702668(-) A-I      intronic
chr1:165702722(-) A-I      intronic
chr1:165708779(-) A-I      intronic
chr1:165726954(-) A-I      intronic
chr1:165707499(-) A-I      intronic
chr1:165709225(-) A-I      intronic
chr1:165709347(-) A-I      intronic
chr1:165698116(-) A-I      intronic
chr1:165699894(-) A-I      intronic
chr1:165714816(-) A-I      intronic
chr1:165709507(-) A-I      intronic
chr1:165702754(-) A-I      intronic
chr1:165713865(-) A-I      intronic
chr1:165705779(-) A-I      intronic
chr1:165700105(-) A-I      intronic
chr1:165703854(-) A-I      intronic
chr1:165709566(-) A-I      intronic
chr1:165698168(-) A-I      intronic
chr1:165709165(-) A-I      intronic
chr1:165714459(-) A-I      intronic
chr1:165698123(-) A-I      intronic
chr1:165698141(-) A-I      intronic
chr1:165698208(-) A-I      intronic
chr1:165698658(-) A-I      intronic
chr1:165702738(-) A-I      intronic
chr1:165726939(-) A-I      intronic
chr1:165714491(-) A-I      intronic
chr1:165727605(-) A-I      intronic
chr1:165726938(-) A-I      intronic
chr1:165700341(-) A-I      intronic
chr1:165726899(-) A-I      intronic
chr1:165709237(-) A-I      intronic
chr1:165705793(-) A-I      intronic
chr1:165713988(-) A-I      intronic
chr1:165714395(-) A-I      intronic
chr1:165706112(-) A-I      intronic
chr1:165726872(-) A-I      intronic
chr1:165698221(-) A-I      intronic
chr1:165699970(-) A-I      intronic
chr1:165711506(-) A-I      intronic
chr1:165706198(-) A-I      intronic
chr1:165709474(-) A-I      intronic
chr1:165699995(-) A-I      intronic
chr1:165702831(-) A-I      intronic
chr1:165698829(-) A-I      intronic
chr1:165698619(-) A-I      intronic
chr1:165714789(-) A-I      intronic
chr1:165702614(-) A-I      intronic
chr1:165713261(-) A-I      intronic
chr1:165700364(-) A-I      intronic
chr1:165735905(-) A-I      intronic
chr1:165726953(-) A-I      intronic
chr1:165709343(-) A-I      intronic
chr1:165703858(-) A-I      intronic
chr1:165724096(-) A-I      intronic
chr1:165714396(-) A-I      intronic
chr1:165727681(-) A-I      intronic
chr1:165714801(-) A-I      intronic
chr1:165705913(-) A-I      intronic
chr1:165700234(-) A-I      intronic
chr1:165698206(-) A-I      intronic
chr1:165709335(-) A-I      intronic
chr1:165714533(-) A-I      intronic
chr1:165709469(-) A-I      intronic
chr1:165714802(-) A-I      intronic
chr1:165698632(-) A-I      intronic
chr1:165697698(-) A-I      intronic
chr1:165698267(-) A-I      intronic
chr1:165705836(-) A-I      intronic
chr1:165708722(-) A-I      intronic
chr1:165698260(-) A-I      intronic
chr1:165698691(-) A-I      intronic
chr1:165702730(-) A-I      intronic
chr1:165698227(-) A-I      intronic
chr1:165699987(-) A-I      intronic
chr1:165727780(-) A-I      intronic
chr1:165700369(-) A-I      intronic
chr1:165698231(-) A-I      intronic
chr1:165734792(-) A-I      intronic
chr1:165727710(-) A-I      intronic
chr1:165706192(-) A-I      intronic
chr1:165699892(-) A-I      intronic
chr1:165698308(-) A-I      intronic
chr1:165706111(-) A-I      intronic
chr1:165709570(-) A-I      intronic
chr1:165721883(-) A-I      intronic
chr1:165703880(-) A-I      intronic
chr1:165700057(-) A-I      intronic
chr1:165721589(-) A-I      intronic
chr1:165707483(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMCO1
chr1:165696800(-) A-I exon 3'UTR    22327324
chr1:165706496(-) G-C intron -    22484847
chr1:165698116(-) A-G intron -    22484847
chr1:165698123(-) A-G intron -    22484847
chr1:165698141(-) A-G intron -    22484847
chr1:165698168(-) A-G intron -    22484847
chr1:165698208(-) A-G intron -    22484847
chr1:165698227(-) A-G intron -    22484847
chr1:165698231(-) A-G intron -    22484847
chr1:165698267(-) A-G intron -    22484847
chr1:165698308(-) A-G intron -    22484847
chr1:165698658(-) A-G intron -    22484847
chr1:165699970(-) A-G intron -    22484847
chr1:165702738(-) A-G intron -    22484847
chr1:165702754(-) A-G intron -    22484847
chr1:165702831(-) A-G intron -    22484847
chr1:165705836(-) A-G intron -    22484847
chr1:165705913(-) A-G intron -    22484847
chr1:165706068(-) A-G intron -    22484847
chr1:165706192(-) A-G intron -    22484847
chr1:165706198(-) A-G intron -    22484847
chr1:165706224(-) A-T intron -    22484847
chr1:165707483(-) A-G intron -    22484847
chr1:165707499(-) A-G intron -    22484847
chr1:165708779(-) A-G intron -    22484847
chr1:165709165(-) A-G intron -    22484847
chr1:165709225(-) A-G intron -    22484847
chr1:165709237(-) A-G intron -    22484847
chr1:165709335(-) A-G intron -    22484847
chr1:165709340(-) A-G intron -    22484847
chr1:165709343(-) A-G intron -    22484847
chr1:165709347(-) A-G intron -    22484847
chr1:165709474(-) A-G intron -    22484847
chr1:165709507(-) A-G intron -    22484847
chr1:165709570(-) A-G intron -    22484847
chr1:165711506(-) A-G intron -    22484847
chr1:165713988(-) A-G intron -    22484847
chr1:165714396(-) A-G intron -    22484847
chr1:165714459(-) A-G intron -    22484847
chr1:165714491(-) A-G intron -    22484847
chr1:165714789(-) A-G intron -    22484847
chr1:165714801(-) A-G intron -    22484847
chr1:165714802(-) A-G intron -    22484847
chr1:165714816(-) A-G intron -    22484847
chr1:165720833(-) G-A intron -    22484847
chr1:165726872(-) A-G intron -    22484847
chr1:165726899(-) A-G intron -    22484847
chr1:165726938(-) A-G intron -    22484847
chr1:165726939(-) A-G intron -    22484847
chr1:165726953(-) A-G intron -    22484847
chr1:165726954(-) A-G intron -    22484847
chr1:165727605(-) A-G intron -    22484847
chr1:165727671(-) A-G intron -    22484847
chr1:165727681(-) A-G intron -    22484847
chr1:165727710(-) A-G intron -    22484847
chr1:165727780(-) A-G intron -    22484847
chr1:165735905(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMCO1
chr1:165696040-165696041(-) m6A 3'UTR       27773535
chr1:165696050-165696051(-) m6A 3'UTR       27773535
chr1:165696133-165696134(-) m6A 3'UTR       27773535
chr1:165697207-165697208(-) m6A 3'UTR       -
chr1:165697222-165697223(-) m6A 3'UTR       -
chr1:165697250-165697251(-) m6A 3'UTR       -
chr1:165697258-165697259(-) m6A 3'UTR       -
chr1:165723494-165723495(-) m6A 3'UTR//5'UTR//CDS       24981863//27773535
chr1:165723506-165723507(-) m6A 3'UTR//5'UTR//CDS       24981863//27773535
chr1:165724111-165724112(-) m6A 3'UTR//intron       24981863//27773535
chr1:165724160-165724161(-) m6A CDS//intron       24981863//27773535//22608085
chr1:165728803-165728804(-) m6A 5'UTR//CDS//intron       24981863//27773535
chr1:165728809-165728810(-) m1A 5'UTR//CDS//intron       26863196
chr1:165737441-165737442(-) m6A 5'UTR//CDS       24981863//27773535
chr1:165737462-165737463(-) m6A 5'UTR//CDS       24981863//27773535
chr1:165737479-165737480(-) m6A 5'UTR//CDS       24981863//27773535
chr1:165737770-165737771(-) m6A 5'UTR//intron       27773535//22575960
chr1:165737968-165737969(-) m6A 5'UTR//CDS//intron       24981863//22575960
chr1:165738185-165738186(-) m6A 5'UTR//intron       24981863
chr1:165738373-165738374(-) m6A 5'UTR//intron       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
TMCO1
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: TMCO1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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