Detail Information

Basic Information:


  VIRBase ID:  

HHID00010701

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           C21orf91:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p C21orf91
miRBase
Accession/Entrez ID		 MIMAT0004588 54149
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - C21orf14//C21orf38//CSSG1//EURL//YG81

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR C21orf91
chr21:19178991(-) A-I      intronic
chr21:19178911(-) A-I      intronic
chr21:19178899(-) A-I      intronic
chr21:19167141(-) A-I      intronic
chr21:19167201(-) A-I      intronic
chr21:19173867(-) A-I      intronic
chr21:19173846(-) A-I      intronic
chr21:19167220(-) A-I      intronic
chr21:19167218(-) A-I      intronic
chr21:19188070(-) A-I      intronic
chr21:19178994(-) A-I      intronic
chr21:19167192(-) A-I      intronic
chr21:19167139(-) A-I      intronic
chr21:19188159(-) A-I      intronic
chr21:19188116(-) A-I      intronic
chr21:19188243(-) A-I      intronic
chr21:19188180(-) A-I      intronic
chr21:19188250(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase C21orf91
chr21:19165615-19165616(-) m6A 3'UTR       22608085
chr21:19165675-19165676(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr21:19165683-19165684(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr21:19165725-19165726(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr21:19165738-19165739(-) m6A 3'UTR//CDS       24284625//24981863//26404942//27773535//22608085
chr21:19165766-19165767(-) m6A 3'UTR//CDS       24284625//24981863//26404942//27773535//22608085
chr21:19165801-19165802(-) m6A 3'UTR//CDS       24284625//24981863//26404942//27773535//22608085
chr21:19165815-19165816(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr21:19168928-19168929(-) m6A CDS       24284625//24209618//27773535//22608085
chr21:19168958-19168959(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr21:19169049-19169050(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22608085
chr21:19169056-19169057(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22608085
chr21:19169218-19169219(-) m6A CDS//exon       24284625//26404942//27773535//22608085
chr21:19169278-19169279(-) m6A CDS//exon       24209618//24981863//26404942//27773535//22608085
chr21:19169300-19169301(-) m6A CDS//exon       24209618//24981863//26404942//27773535//22608085
chr21:19169353-19169354(-) m6A CDS//exon       24209618//24981863//26404942//27773535//22608085
chr21:19169383-19169384(-) m6A CDS//exon       24209618//24981863//27773535//22608085
chr21:19183720-19183721(-) m6A exon//intron       27773535//22608085
chr21:19183780-19183781(-) m6A exon//intron       27773535
chr21:19190501-19190502(-) m6A exon//intron       22608085
chr21:19190550-19190551(-) m6A CDS//exon       24981863//27371828//22608085
chr21:19190562-19190563(-) m6A CDS//exon       25456834//24981863//27371828//22608085
chr21:19190569-19190570(-) m6A CDS//exon       25456834//24981863//27371828//22608085
chr21:19190609-19190610(-) m6A CDS//exon       25456834//24981863//27371828//22608085
chr21:19191196-19191197(-) m6A 5'UTR//intron       25456834//24981863//27371828//22608085
chr21:19191663-19191664(-) m6A 5'UTR//exon       25456834
chr21:19191677-19191678(-) m6A 5'UTR//exon       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
C21orf91
Chromatin K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: C21orf91

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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