Basic Information:

  VIRBase ID:  

HHID00010652

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          SH3GLB1:  NM_016009     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	SH3GLB1
miRBase Accession/Entrez ID	MIMAT0004588	51100
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	Bif-1//CGI-61//dJ612B15.2//PPP1R70

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SH3GLB1	chr1:87207942(+) A-I      Syn:Val->Val chr1:87205594(+) A-I      intronic chr1:87205578(+) A-I      intronic chr1:87205782(+) A-I      intronic chr1:87208545(+) A-I      intronic chr1:87204342(+) A-I      intronic chr1:87208387(+) A-I      intronic chr1:87204467(+) A-I      intronic chr1:87205718(+) A-I      intronic chr1:87205621(+) A-I      intronic chr1:87205752(+) A-I      intronic chr1:87204090(+) A-I      intronic chr1:87197601(+) A-I      intronic chr1:87208380(+) A-I      intronic chr1:87208410(+) A-I      intronic chr1:87204379(+) A-I      intronic chr1:87205753(+) A-I      intronic chr1:87205663(+) A-I      intronic chr1:87205722(+) A-I      intronic chr1:87204451(+) A-I      intronic chr1:87196367(+) A-I      intronic chr1:87205708(+) A-I      intronic chr1:87204532(+) A-I      intronic chr1:87196364(+) A-I      intronic chr1:87197543(+) A-I      intronic chr1:87205762(+) A-I      intronic chr1:87205726(+) A-I      intronic chr1:87205682(+) A-I      intronic chr1:87204155(+) A-I      intronic chr1:87197722(+) A-I      intronic chr1:87197718(+) A-I      intronic chr1:87204459(+) A-I      intronic chr1:87204382(+) A-I      intronic chr1:87204088(+) A-I      intronic chr1:87205758(+) A-I      intronic chr1:87205790(+) A-I      intronic chr1:87212297(+) A-I      3'UTR chr1:87205714(+) A-I      intronic chr1:87197553(+) A-I      intronic chr1:87204617(+) A-I      intronic chr1:87205632(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SH3GLB1	chr1:87188959(+) T-C intron -    22484847 chr1:87196367(+) A-G intron -    22484847 chr1:87196375(+) T-G intron -    22484847 chr1:87197601(+) A-G intron -    22484847 chr1:87204227(+) C-T intron -    22484847 chr1:87204382(+) A-G intron -    22484847 chr1:87204441(+) T-C intron -    22484847 chr1:87204532(+) A-G intron -    22484847 chr1:87205708(+) A-G intron -    22484847 chr1:87205714(+) A-G intron -    22484847 chr1:87205722(+) A-G intron -    22484847 chr1:87208380(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SH3GLB1	chr1:87170272-87170273(+) m6A 5'UTR       24981863//22608085 chr1:87170609-87170610(+) m1A 5'UTR//CDS       26863410//26863196 chr1:87181499-87181500(+) m6A CDS//intron       27773535 chr1:87181516-87181517(+) m6A CDS//intron       27773535 chr1:87185259-87185260(+) m6A 5'UTR//CDS       26404942 chr1:87185268-87185269(+) m6A 5'UTR//CDS       26404942 chr1:87185290-87185291(+) m6A CDS       26404942 chr1:87185308-87185309(+) m6A CDS       26404942 chr1:87208087-87208088(+) m6A CDS       27773535//22608085 chr1:87208847-87208848(+) m6A CDS       24284625//24981863//27773535//22608085 chr1:87208871-87208872(+) m6A CDS       24284625//24981863//27773535//22608085 chr1:87208905-87208906(+) m6A CDS       24284625//24981863//27773535//22608085 chr1:87208926-87208927(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr1:87209020-87209021(+) m6A 3'UTR       24981863//22608085 chr1:87209043-87209044(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	SH3GLB1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: SH3GLB1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).