Detail Information

Basic Information:


  VIRBase ID:  

HHID00010634

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           CERS2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p CERS2
miRBase
Accession/Entrez ID		 MIMAT0004588 29956
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - L3//LASS2//SP260//TMSG1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CERS2
chr1:150937513(-) A-I      intronic
chr1:150937454(-) A-I      intronic
chr1:150937540(-) A-I      intronic
chr1:150937463(-) A-I      intronic
chr1:150934823(-) A-I      intronic
chr1:150933926(-) A-I      intronic
chr1:150933917(-) A-I      intronic
chr1:150937531(-) A-I      intronic
chr1:150934838(-) A-I      intronic
chr1:150934813(-) A-I      intronic
chr1:150937444(-) A-I      intronic
chr1:150934805(-) A-I      intronic
chr1:150934850(-) A-I      intronic
chr1:150934791(-) A-I      intronic
chr1:150934814(-) A-I      intronic
chr1:150934003(-) A-I      intronic
chr1:150934827(-) A-I      intronic
chr1:150934824(-) A-I      intronic
chr1:150933974(-) A-I      intronic
chr1:150934822(-) A-I      intronic
chr1:150934821(-) A-I      intronic
chr1:150934820(-) A-I      intronic
chr1:150934818(-) A-I      intronic
chr1:150933982(-) A-I      intronic
chr1:150934815(-) A-I      intronic
chr1:150934809(-) A-I      intronic
chr1:150934789(-) A-I      intronic
chr1:150934750(-) A-I      intronic
chr1:150934783(-) A-I      intronic
chr1:150934734(-) A-I      intronic
chr1:150934773(-) A-I      intronic
chr1:150934777(-) A-I      intronic
chr1:150937570(-) A-I      intronic
chr1:150937530(-) A-I      intronic
chr1:150934720(-) A-I      intronic
chr1:150937529(-) A-I      intronic
chr1:150934712(-) A-I      intronic
chr1:150934707(-) A-I      intronic
chr1:150937512(-) A-I      intronic
chr1:150937503(-) A-I      intronic
chr1:150937476(-) A-I      intronic
chr1:150934770(-) A-I      intronic
chr1:150937471(-) A-I      intronic
chr1:150937587(-) A-I      intronic
chr1:150937467(-) A-I      intronic
chr1:150937450(-) A-I      intronic
chr1:150934939(-) A-I      intronic
chr1:150934934(-) A-I      intronic
chr1:150934926(-) A-I      intronic
chr1:150934925(-) A-I      intronic
chr1:150934678(-) A-I      intronic
chr1:150934872(-) A-I      intronic
chr1:150934049(-) A-I      intronic
chr1:150933863(-) A-I      intronic
chr1:150933872(-) A-I      intronic
chr1:150934864(-) A-I      intronic
chr1:150933938(-) A-I      intronic
chr1:150933947(-) A-I      intronic
chr1:150933950(-) A-I      intronic
chr1:150934863(-) A-I      intronic
chr1:150934861(-) A-I      intronic
chr1:150933960(-) A-I      intronic
chr1:150933964(-) A-I      intronic
chr1:150933967(-) A-I      intronic
chr1:150943190(-) A-I      intronic
chr1:150943164(-) A-I      intronic
chr1:150933983(-) A-I      intronic
chr1:150943000(-) A-I      intronic
chr1:150943267(-) A-I      intronic
chr1:150941807(-) A-I      intronic
chr1:150943149(-) A-I      intronic
chr1:150943064(-) A-I      intronic
chr1:150937435(-) A-I      intronic
chr1:150942012(-) A-I      intronic
chr1:150937477(-) A-I      intronic
chr1:150941867(-) A-I      intronic
chr1:150934679(-) A-I      intronic
chr1:150934048(-) A-I      intronic
chr1:150934007(-) A-I      intronic
chr1:150937515(-) A-I      intronic
chr1:150941939(-) A-I      intronic
chr1:150941858(-) A-I      intronic
chr1:150941887(-) A-I      intronic
chr1:150937436(-) A-I      intronic
chr1:150942997(-) A-I      intronic
chr1:150937539(-) A-I      intronic
chr1:150943213(-) A-I      intronic
chr1:150943266(-) A-I      intronic
chr1:150943172(-) A-I      intronic
chr1:150942641(-) A-I      intronic
chr1:150937524(-) A-I      intronic
chr1:150942538(-) A-I      intronic
chr1:150942501(-) A-I      intronic
chr1:150942996(-) A-I      intronic
chr1:150943110(-) A-I      intronic
chr1:150943063(-) A-I      intronic
chr1:150942020(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CERS2
chr1:150933075-150933076(-) m6A exon       24284625//24209618//24981863//22608085
chr1:150933165-150933166(-) m6A exon       24284625//24209618//24981863//22608085
chr1:150935453-150935454(-) m6A exon       24284625//24209618//24981863//22575960//22608085
chr1:150935464-150935465(-) m6A exon       24284625//24209618//24981863//22575960//22608085
chr1:150936893-150936894(-) m6A CDS//exon       24284625//24981863
chr1:150936923-150936924(-) m6A CDS//exon       24284625
chr1:150936971-150936972(-) m6A exon//intron       24284625
chr1:150938044-150938045(-) m6A 3'UTR//exon//intron       26404942
chr1:150938158-150938159(-) m6A 3'UTR//exon//intron       26404942
chr1:150938465-150938466(-) m6A 3'UTR//exon//intron       26404942//27773535
chr1:150938577-150938578(-) m6A 3'UTR//exon//intron       24284625//24981863//26404942//27773535//22608085
chr1:150938622-150938623(-) m6A 3'UTR//exon//intron       24284625//24981863//26404942//27773535//22608085
chr1:150938730-150938731(-) m6A CDS//exon//intron       24981863//26404942
chr1:150939303-150939304(-) m6A CDS//exon       27773535
chr1:150941486-150941487(-) m6A CDS//intron       22575960
chr1:150941510-150941511(-) m6A CDS//intron       22575960
chr1:150941552-150941553(-) Y CDS//intron       26075521
chr1:150941556-150941557(-) m6A CDS//intron       22575960
chr1:150941636-150941637(-) m6A 5'UTR//intron       24209618

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
CERS2
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: CERS2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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