Detail Information

Basic Information:


  VIRBase ID:  

HHID00010617

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           SMPDL3B:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p SMPDL3B
miRBase
Accession/Entrez ID		 MIMAT0004588 27293
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ASML3B

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SMPDL3B
chr1:28272805(+) A-I      intronic
chr1:28277363(+) A-I      intronic
chr1:28269090(+) A-I      intronic
chr1:28270927(+) A-I      intronic
chr1:28272609(+) A-I      intronic
chr1:28272610(+) A-I      intronic
chr1:28277242(+) A-I      intronic
chr1:28272814(+) A-I      intronic
chr1:28272753(+) A-I      intronic
chr1:28270366(+) A-I      intronic
chr1:28274022(+) A-I      intronic
chr1:28272730(+) A-I      intronic
chr1:28272827(+) A-I      intronic
chr1:28272852(+) A-I      intronic
chr1:28274035(+) A-I      intronic
chr1:28274283(+) A-I      intronic
chr1:28274294(+) A-I      intronic
chr1:28274296(+) A-I      intronic
chr1:28277018(+) A-I      intronic
chr1:28277191(+) A-I      intronic
chr1:28278233(+) A-I      intronic
chr1:28278249(+) A-I      intronic
chr1:28278275(+) A-I      intronic
chr1:28278299(+) A-I      intronic
chr1:28278302(+) A-I      intronic
chr1:28270333(+) A-I      intronic
chr1:28270334(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SMPDL3B
chr1:28261562-28261563(+) m6A 5'UTR       25456834//24981863
chr1:28261569-28261570(+) m6A 5'UTR//exon       25456834//24981863
chr1:28261583-28261584(+) m6A 5'UTR//exon       25456834//24981863
chr1:28261618-28261619(+) m6A 5'UTR//exon       25456834//24981863
chr1:28261643-28261644(+) m6A 5'UTR//exon       25456834//24981863
chr1:28282743-28282744(+) m6A 3'UTR//intron       24981863
chr1:28285119-28285120(+) m6A 3'UTR//CDS       22608085
chr1:28285242-28285243(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22608085
chr1:28285450-28285451(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr1:28285461-28285462(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr1:28285545-28285546(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr1:28285558-28285559(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr1:28285569-28285570(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr1:28285593-28285594(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr1:28285641-28285642(+) m6A 3'UTR       24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
SMPDL3B
Chromatin K562 cells     -
Exosome Blood     -
Nucleus HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: SMPDL3B

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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