Detail Information

Basic Information:


  VIRBase ID:  

HHID00010567

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           PRKD3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p PRKD3
miRBase
Accession/Entrez ID		 MIMAT0004588 23683
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EPK2//nPKC-NU//PKC-NU//PKD3//PRKCN

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PRKD3
chr2:37493657(-) A-I      intronic
chr2:37493659(-) A-I      intronic
chr2:37493687(-) A-I      intronic
chr2:37478289(-) A-I      3'UTR
chr2:37478218(-) A-I      3'UTR
chr2:37478258(-) A-I      3'UTR
chr2:37478256(-) A-I      3'UTR
chr2:37478242(-) A-I      3'UTR
chr2:37493697(-) A-I      intronic
chr2:37478237(-) A-I      3'UTR
chr2:37493698(-) A-I      intronic
chr2:37536879(-) A-I      intronic
chr2:37536799(-) A-I      intronic
chr2:37535801(-) A-I      intronic
chr2:37535794(-) A-I      intronic
chr2:37535780(-) A-I      intronic
chr2:37535766(-) A-I      intronic
chr2:37535758(-) A-I      intronic
chr2:37535598(-) A-I      intronic
chr2:37526623(-) A-I      intronic
chr2:37522109(-) A-I      intronic
chr2:37493903(-) A-I      intronic
chr2:37493906(-) A-I      intronic
chr2:37493606(-) A-I      intronic
chr2:37519664(-) A-I      intronic
chr2:37488707(-) A-I      intronic
chr2:37547683(-) A-I      intronic
chr2:37536891(-) A-I      intronic
chr2:37536908(-) A-I      intronic
chr2:37488492(-) A-I      intronic
chr2:37526562(-) A-I      intronic
chr2:37522159(-) A-I      intronic
chr2:37493834(-) A-I      intronic
chr2:37488918(-) A-I      intronic
chr2:37488482(-) A-I      intronic
chr2:37522208(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PRKD3
chr2:37506908(-) G-A exon CDS    21725310
chr2:37493732(-) G-A intron -    22484847
chr2:37522159(-) A-G intron -    22484847
chr2:37531905(-) C-T intron -    22484847
chr2:37536891(-) A-G intron -    22484847
chr2:37536957(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PRKD3
chr2:37480100-37480101(-) m6A 3'UTR       27773535
chr2:37480148-37480149(-) m6A 3'UTR       27773535//22608085
chr2:37480277-37480278(-) m6A 3'UTR       24981863//26404942//27773535//22608085
chr2:37480456-37480457(-) m6A CDS       24284625//27371828//22608085
chr2:37480483-37480484(-) m6A CDS       24284625//22608085
chr2:37494664-37494665(-) m6A CDS//exon       27773535
chr2:37494674-37494675(-) m6A CDS//exon       27773535
chr2:37494739-37494740(-) m6A exon//intron       27773535
chr2:37494797-37494798(-) m6A exon//intron       27773535
chr2:37501666-37501667(-) m6A CDS//exon       25456834//22608085
chr2:37501706-37501707(-) m6A CDS//exon       25456834
chr2:37505157-37505158(-) m6A exon//intron       27773535
chr2:37506895-37506896(-) m6A CDS//exon       27773535
chr2:37507054-37507055(-) m6A CDS//exon       27773535
chr2:37543430-37543431(-) m6A CDS//exon//intron       24284625//24981863
chr2:37543562-37543563(-) m6A CDS//exon//intron       24284625//24981863//27773535//22608085
chr2:37543726-37543727(-) m6A 5'UTR//exon//intron       24284625//24209618//24981863//27773535//22608085
chr2:37543826-37543827(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//22575960//22608085
chr2:37543855-37543856(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr2:37543876-37543877(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr2:37543892-37543893(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr2:37543897-37543898(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr2:37544002-37544003(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr2:37544012-37544013(-) m6A 5'UTR//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr2:37544051-37544052(-) m6A 5'UTR//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr2:37544097-37544098(-) m6A 5'UTR//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr2:37544131-37544132(-) m6A 5'UTR//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr2:37544163-37544164(-) m6A 5'UTR//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr2:37544191-37544192(-) m6A 5'UTR//exon//intron       24284625//24209618//24981863//27773535//22608085
chr2:37544282-37544283(-) m6A 5'UTR//exon//intron       24284625//24209618//27773535//22608085
chr2:37544953-37544954(-) m6A 5'UTR//intron       24284625//24209618//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
PRKD3
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: PRKD3

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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