Basic Information:

  VIRBase ID:  

HHID00010534

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:  MIMAT0004588          KANK1:  NR_148869     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-27b-5p	KANK1
miRBase Accession/Entrez ID	MIMAT0004588	23189
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ANKRD15//CPSQ2//KANK

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-27b-5p	rs1427122962 chr9:95085474    G/T rs746975163 chr9:95085473    T/C rs1232338919 chr9:95085466    G/A rs763344276 chr9:95085469    T/C rs773727004 chr9:95085467    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KANK1	chr9:531308(+) A-I      intronic chr9:660172(+) A-I      intronic chr9:632776(+) A-I      intronic chr9:718439(+) A-I      intronic chr9:718438(+) A-I      intronic chr9:717200(+) A-I      intronic chr9:660167(+) A-I      intronic chr9:660164(+) A-I      intronic chr9:633818(+) A-I      intronic chr9:633841(+) A-I      intronic chr9:633903(+) A-I      intronic chr9:660222(+) A-I      intronic chr9:620043(+) A-I      intronic chr9:660220(+) A-I      intronic chr9:660219(+) A-I      intronic chr9:644865(+) A-I      intronic chr9:644866(+) A-I      intronic chr9:644874(+) A-I      intronic chr9:645186(+) A-I      intronic chr9:645203(+) A-I      intronic chr9:645319(+) A-I      intronic chr9:660163(+) A-I      intronic chr9:660150(+) A-I      intronic chr9:660147(+) A-I      intronic chr9:660141(+) A-I      intronic chr9:660160(+) A-I      intronic chr9:660159(+) A-I      intronic chr9:660158(+) A-I      intronic chr9:735787(+) A-I      intronic chr9:735835(+) A-I      intronic chr9:735836(+) A-I      intronic chr9:735866(+) A-I      intronic chr9:615008(+) A-I      intronic chr9:735944(+) A-I      intronic chr9:615004(+) A-I      intronic chr9:660156(+) A-I      intronic chr9:595549(+) A-I      intronic chr9:726596(+) A-I      intronic chr9:595148(+) A-I      intronic chr9:660155(+) A-I      intronic chr9:726580(+) A-I      intronic chr9:726528(+) A-I      intronic chr9:660152(+) A-I      intronic chr9:623560(+) A-I      intronic chr9:507240(+) A-I      intronic chr9:509192(+) A-I      intronic chr9:509197(+) A-I      intronic chr9:509202(+) A-I      intronic chr9:509358(+) A-I      intronic chr9:509896(+) A-I      intronic chr9:517878(+) A-I      intronic chr9:518984(+) A-I      intronic chr9:519020(+) A-I      intronic chr9:519036(+) A-I      intronic chr9:624621(+) A-I      intronic chr9:520076(+) A-I      intronic chr9:595655(+) A-I      intronic chr9:595675(+) A-I      intronic chr9:691837(+) A-I      intronic chr9:705365(+) A-I      intronic chr9:709696(+) A-I      intronic chr9:720369(+) A-I      intronic chr9:720477(+) A-I      intronic chr9:660182(+) A-I      intronic chr9:660217(+) A-I      intronic chr9:660213(+) A-I      intronic chr9:660210(+) A-I      intronic chr9:595158(+) A-I      intronic chr9:595164(+) A-I      intronic chr9:595172(+) A-I      intronic chr9:595186(+) A-I      intronic chr9:660206(+) A-I      intronic chr9:660205(+) A-I      intronic chr9:597917(+) A-I      intronic chr9:597926(+) A-I      intronic chr9:597927(+) A-I      intronic chr9:660200(+) A-I      intronic chr9:597955(+) A-I      intronic chr9:644911(+) A-I      intronic chr9:644919(+) A-I      intronic chr9:644935(+) A-I      intronic chr9:644967(+) A-I      intronic chr9:644968(+) A-I      intronic chr9:644974(+) A-I      intronic chr9:573546(+) A-I      intronic chr9:573532(+) A-I      intronic chr9:572367(+) A-I      intronic chr9:645280(+) A-I      intronic chr9:645287(+) A-I      intronic chr9:645333(+) A-I      intronic chr9:704869(+) A-I      intronic chr9:704871(+) A-I      intronic chr9:704882(+) A-I      intronic chr9:704908(+) A-I      intronic chr9:704913(+) A-I      intronic chr9:704932(+) A-I      intronic chr9:726487(+) A-I      intronic chr9:726496(+) A-I      intronic chr9:735952(+) A-I      intronic chr9:735965(+) A-I      intronic chr9:691779(+) A-I      intronic chr9:572350(+) A-I      intronic chr9:572289(+) A-I      intronic chr9:572256(+) A-I      intronic chr9:551997(+) A-I      intronic chr9:544221(+) A-I      intronic chr9:543516(+) A-I      intronic chr9:736169(+) A-I      intronic chr9:736432(+) A-I      intronic chr9:736442(+) A-I      intronic chr9:692760(+) A-I      intronic chr9:692777(+) A-I      intronic chr9:507171(+) A-I      intronic chr9:692783(+) A-I      intronic chr9:624643(+) A-I      intronic chr9:699861(+) A-I      intronic chr9:699874(+) A-I      intronic chr9:703227(+) A-I      intronic chr9:704886(+) A-I      intronic chr9:704890(+) A-I      intronic chr9:704918(+) A-I      intronic chr9:660198(+) A-I      intronic chr9:704925(+) A-I      intronic chr9:660195(+) A-I      intronic chr9:709664(+) A-I      intronic chr9:660184(+) A-I      intronic chr9:645815(+) A-I      intronic chr9:660180(+) A-I      intronic chr9:543484(+) A-I      intronic chr9:543480(+) A-I      intronic chr9:531372(+) A-I      intronic chr9:531333(+) A-I      intronic chr9:726486(+) A-I      intronic chr9:527944(+) A-I      intronic chr9:527943(+) A-I      intronic chr9:724520(+) A-I      intronic chr9:723916(+) A-I      intronic chr9:723911(+) A-I      intronic chr9:723909(+) A-I      intronic chr9:723824(+) A-I      intronic chr9:723821(+) A-I      intronic chr9:520296(+) A-I      intronic chr9:520280(+) A-I      intronic chr9:660179(+) A-I      intronic chr9:520217(+) A-I      intronic chr9:520191(+) A-I      intronic chr9:520136(+) A-I      intronic chr9:520132(+) A-I      intronic chr9:515198(+) A-I      intronic chr9:515166(+) A-I      intronic chr9:660178(+) A-I      intronic chr9:515165(+) A-I      intronic chr9:509995(+) A-I      intronic chr9:509942(+) A-I      intronic chr9:509847(+) A-I      intronic chr9:507342(+) A-I      intronic chr9:507304(+) A-I      intronic chr9:507224(+) A-I      intronic chr9:507199(+) A-I      intronic chr9:660177(+) A-I      intronic chr9:652266(+) A-I      intronic chr9:660176(+) A-I      intronic chr9:626334(+) A-I      intronic chr9:626344(+) A-I      intronic chr9:528067(+) A-I      intronic chr9:508267(+) A-I      intronic chr9:550489(+) A-I      intronic chr9:544304(+) A-I      intronic chr9:510074(+) A-I      intronic chr9:645297(+) A-I      intronic chr9:603874(+) A-I      intronic chr9:603701(+) A-I      intronic chr9:652265(+) A-I      intronic chr9:623531(+) A-I      intronic chr9:595742(+) A-I      intronic chr9:575902(+) A-I      intronic chr9:639417(+) A-I      intronic chr9:526511(+) A-I      intronic chr9:645403(+) A-I      intronic chr9:575564(+) A-I      intronic chr9:531356(+) A-I      intronic chr9:717211(+) A-I      intronic chr9:536083(+) A-I      intronic chr9:544297(+) A-I      intronic chr9:543509(+) A-I      intronic chr9:710530(+) A-I      intronic chr9:517370(+) A-I      intronic chr9:704709(+) A-I      intronic chr9:704726(+) A-I      intronic chr9:508239(+) A-I      intronic chr9:531350(+) A-I      intronic chr9:717030(+) A-I      intronic chr9:735833(+) A-I      intronic chr9:531394(+) A-I      intronic chr9:528851(+) A-I      intronic chr9:518971(+) A-I      intronic chr9:517233(+) A-I      intronic chr9:515177(+) A-I      intronic chr9:735880(+) A-I      intronic chr9:509237(+) A-I      intronic chr9:606392(+) A-I      intronic chr9:606371(+) A-I      intronic chr9:595180(+) A-I      intronic chr9:736556(+) A-I      intronic chr9:736140(+) A-I      intronic chr9:720439(+) A-I      intronic chr9:735852(+) A-I      intronic chr9:645263(+) A-I      intronic chr9:543465(+) A-I      intronic chr9:626324(+) A-I      intronic chr9:543405(+) A-I      intronic chr9:528939(+) A-I      intronic chr9:725341(+) A-I      intronic chr9:595643(+) A-I      intronic chr9:520167(+) A-I      intronic chr9:507529(+) A-I      intronic chr9:736588(+) A-I      intronic chr9:726840(+) A-I      intronic chr9:572233(+) A-I      intronic chr9:657992(+) A-I      intronic chr9:735829(+) A-I      intronic chr9:691707(+) A-I      intronic chr9:507194(+) A-I      intronic chr9:704703(+) A-I      intronic chr9:704797(+) A-I      intronic chr9:645293(+) A-I      intronic chr9:630125(+) A-I      intronic chr9:544082(+) A-I      intronic chr9:632894(+) A-I      intronic chr9:508219(+) A-I      intronic chr9:718407(+) A-I      intronic chr9:575900(+) A-I      intronic chr9:644945(+) A-I      intronic chr9:743741(+) A-I      intronic chr9:519170(+) A-I      intronic chr9:575886(+) A-I      intronic chr9:574653(+) A-I      intronic chr9:531210(+) A-I      intronic chr9:544291(+) A-I      intronic chr9:736529(+) A-I      intronic chr9:704819(+) A-I      intronic chr9:507192(+) A-I      intronic chr9:720726(+) A-I      intronic chr9:692927(+) A-I      intronic chr9:606370(+) A-I      intronic chr9:507196(+) A-I      intronic chr9:527428(+) A-I      intronic chr9:724637(+) A-I      intronic chr9:507191(+) A-I      intronic chr9:510021(+) A-I      intronic chr9:572399(+) A-I      intronic chr9:714060(+) A-I      intronic chr9:726518(+) A-I      intronic chr9:736205(+) A-I      intronic chr9:705336(+) A-I      intronic chr9:657971(+) A-I      intronic chr9:520284(+) A-I      intronic chr9:623447(+) A-I      intronic chr9:643807(+) A-I      intronic chr9:520272(+) A-I      intronic chr9:507234(+) A-I      intronic chr9:736430(+) A-I      intronic chr9:519076(+) A-I      intronic chr9:735940(+) A-I      intronic chr9:735838(+) A-I      intronic chr9:544178(+) A-I      intronic chr9:735875(+) A-I      intronic chr9:703763(+) A-I      intronic chr9:526457(+) A-I      intronic chr9:710573(+) A-I      intronic chr9:603798(+) A-I      intronic chr9:736572(+) A-I      intronic chr9:543425(+) A-I      intronic chr9:735945(+) A-I      intronic chr9:639591(+) A-I      intronic chr9:644981(+) A-I      intronic chr9:717195(+) A-I      intronic chr9:639456(+) A-I      intronic chr9:543577(+) A-I      intronic chr9:531351(+) A-I      intronic chr9:736143(+) A-I      intronic chr9:507228(+) A-I      intronic chr9:736239(+) A-I      intronic chr9:710471(+) A-I      intronic chr9:736087(+) A-I      intronic chr9:557134(+) A-I      intronic chr9:509198(+) A-I      intronic chr9:720638(+) A-I      intronic chr9:736233(+) A-I      intronic chr9:515088(+) A-I      intronic chr9:509177(+) A-I      intronic chr9:726849(+) A-I      intronic chr9:548801(+) A-I      intronic chr9:531181(+) A-I      intronic chr9:507280(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	KANK1	chr9:539539(+) A-I intron -    15258596 chr9:539620(+) A-I intron -    15258596 chr9:539621(+) A-I intron -    15258596

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KANK1	chr9:470593-470594(+) m6A 5'UTR//exon       25456834 chr9:470655-470656(+) m6A 5'UTR//exon       25456834 chr9:471478-471479(+) m6A exon//intron       - chr9:477961-477962(+) m6A intron       - chr9:478037-478038(+) m6A intron       24284625//25456834//22608085 chr9:478051-478052(+) m6A intron       24284625//25456834//22608085 chr9:478065-478066(+) m6A intron       24284625//25456834//22608085 chr9:478115-478116(+) m6A intron       24284625//25456834//22608085 chr9:478122-478123(+) m6A intron       24284625//25456834//22608085 chr9:478137-478138(+) m6A intron       24284625//25456834 chr9:478220-478221(+) m6A intron       24284625//25456834 chr9:478230-478231(+) m6A intron       24284625//25456834 chr9:478251-478252(+) m6A intron       25456834 chr9:549302-549303(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr9:549432-549433(+) m6A 5'UTR//intron       25456834//24981863 chr9:549437-549438(+) m6A 5'UTR//intron       25456834//24981863 chr9:706893-706894(+) m6A 5'UTR//intron       24209618 chr9:706966-706967(+) m6A 5'UTR//intron       24209618 chr9:710830-710831(+) m6A 5'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr9:710836-710837(+) m6A 5'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr9:710843-710844(+) m6A 5'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr9:710851-710852(+) m6A 5'UTR//CDS//exon       24284625//24209618//24981863//22608085 chr9:710868-710869(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:710890-710891(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:710945-710946(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr9:710950-710951(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr9:710990-710991(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr9:710997-710998(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr9:711024-711025(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr9:711144-711145(+) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr9:711234-711235(+) m6A 5'UTR//CDS//exon       24284625//24209618//24981863 chr9:711246-711247(+) m6A CDS//exon       24284625//24209618//24981863 chr9:711257-711258(+) m6A CDS//exon       24284625//24209618//24981863 chr9:711263-711264(+) m6A CDS//exon       24284625//24209618//24981863 chr9:711376-711377(+) m6A CDS//exon       24284625 chr9:711764-711765(+) m6A CDS//exon       24284625//22608085 chr9:711785-711786(+) m1A CDS//exon       26863196 chr9:711831-711832(+) m6A CDS//exon       24284625//24981863//22608085 chr9:711839-711840(+) m6A CDS//exon       24284625//24981863//22608085 chr9:711883-711884(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr9:711913-711914(+) m6A CDS//exon       24284625//24209618//24981863//22575960 chr9:711988-711989(+) m6A CDS//exon       24284625//24209618//25456834//22575960 chr9:712050-712051(+) m6A CDS//exon       24209618//25456834 chr9:712146-712147(+) m6A CDS//exon       24209618 chr9:712200-712201(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr9:712226-712227(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr9:712232-712233(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr9:712329-712330(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:712336-712337(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:712360-712361(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:712369-712370(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:712383-712384(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:712395-712396(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:712569-712570(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:712617-712618(+) m6A CDS//exon       24209618//24981863//27773535//22575960//22608085 chr9:712717-712718(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr9:712774-712775(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr9:712780-712781(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr9:712799-712800(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr9:712876-712877(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr9:712884-712885(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr9:712896-712897(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr9:712911-712912(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr9:712942-712943(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr9:713031-713032(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:713097-713098(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:713194-713195(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr9:713273-713274(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr9:713280-713281(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr9:713296-713297(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr9:713306-713307(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr9:713327-713328(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr9:713425-713426(+) m6A CDS//exon       25456834//24981863//22608085 chr9:713442-713443(+) m6A CDS//exon       - chr9:732472-732473(+) m1A CDS//exon       26863196 chr9:732496-732497(+) m6A CDS//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-27b-5p	Exosome Breast milk     22211110 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	KANK1	Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-27b-5p	Progesterone 5994 Drug interaction    RC00006922 5-Fluorouracil 3385 Drug interaction    RC00006921 Lenalidomide 216326 Drug interaction    RC00006923

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-27b-5p	Cisplatin 5702198       26676926 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-27b-5p
Interactor2: KANK1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).