Detail Information

Basic Information:


  VIRBase ID:  

HHID00010512

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           BTBD3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p BTBD3
miRBase
Accession/Entrez ID		 MIMAT0004588 22903
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - dJ742J24.1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BTBD3
chr20:11875468(+) A-I      intronic
chr20:11875474(+) A-I      intronic
chr20:11878619(+) A-I      intronic
chr20:11875461(+) A-I      intronic
chr20:11878629(+) A-I      intronic
chr20:11878645(+) A-I      intronic
chr20:11876007(+) A-I      intronic
chr20:11875464(+) A-I      intronic
chr20:11876005(+) A-I      intronic
chr20:11875972(+) A-I      intronic
chr20:11876022(+) A-I      intronic
chr20:11876008(+) A-I      intronic
chr20:11878620(+) A-I      intronic
chr20:11878630(+) A-I      intronic
chr20:11884341(+) A-I      intronic
chr20:11889737(+) A-I      intronic
chr20:11884355(+) A-I      intronic
chr20:11884274(+) A-I      intronic
chr20:11889663(+) A-I      intronic
chr20:11889819(+) A-I      intronic
chr20:11881541(+) A-I      intronic
chr20:11887180(+) A-I      intronic
chr20:11884519(+) A-I      intronic
chr20:11889828(+) A-I      intronic
chr20:11889801(+) A-I      intronic
chr20:11889802(+) A-I      intronic
chr20:11878686(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BTBD3
chr20:11898563-11898564(+) m6A 5'UTR//intron       24981863//22575960
chr20:11898671-11898672(+) m6A 5'UTR//intron       24981863
chr20:11898879-11898880(+) m6A 5'UTR//intron       24284625//22608085
chr20:11898910-11898911(+) m6A 5'UTR//intron       24284625//22575960//22608085
chr20:11898945-11898946(+) m6A CDS//intron       24284625//24981863//22575960//22608085
chr20:11898993-11898994(+) m6A 5'UTR//CDS       24284625//24981863//22575960//22608085
chr20:11899091-11899092(+) m6A 5'UTR//CDS       24284625//24981863//26404942//22608085
chr20:11899103-11899104(+) m1A 5'UTR//CDS       26863196
chr20:11899215-11899216(+) m6A CDS       24981863
chr20:11900457-11900458(+) m6A 3'UTR//CDS//exon       24284625
chr20:11903396-11903397(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085
chr20:11903460-11903461(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085
chr20:11903546-11903547(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr20:11903573-11903574(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr20:11903777-11903778(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085
chr20:11904025-11904026(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr20:11904057-11904058(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr20:11904135-11904136(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr20:11904175-11904176(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr20:11904190-11904191(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr20:11904295-11904296(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr20:11904316-11904317(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr20:11904564-11904565(+) m6A 3'UTR       24284625//22608085
chr20:11904673-11904674(+) m6A 3'UTR       24981863//22608085
chr20:11904707-11904708(+) m6A 3'UTR       24981863//22608085
chr20:11904712-11904713(+) m6A 3'UTR       24981863
chr20:11904731-11904732(+) m6A 3'UTR       24981863
chr20:11904739-11904740(+) m6A 3'UTR       24981863
chr20:11905313-11905314(+) Y 3'UTR       25192136

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
BTBD3
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: BTBD3

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

Starting a new search, please wait ...