Detail Information

Basic Information:


  VIRBase ID:  

HHID00010496

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           ZHX1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p ZHX1
miRBase
Accession/Entrez ID		 MIMAT0004588 11244
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZHX1
chr8:124277347(-) A-I      intronic
chr8:124268876(-) A-I      intronic
chr8:124277310(-) A-I      intronic
chr8:124277291(-) A-I      intronic
chr8:124268909(-) A-I      intronic
chr8:124268917(-) A-I      intronic
chr8:124269237(-) A-I      intronic
chr8:124268880(-) A-I      intronic
chr8:124269287(-) A-I      intronic
chr8:124269291(-) A-I      intronic
chr8:124269306(-) A-I      intronic
chr8:124277072(-) A-I      intronic
chr8:124277071(-) A-I      intronic
chr8:124269323(-) A-I      intronic
chr8:124269327(-) A-I      intronic
chr8:124269329(-) A-I      intronic
chr8:124277063(-) A-I      intronic
chr8:124276935(-) A-I      intronic
chr8:124269337(-) A-I      intronic
chr8:124269352(-) A-I      intronic
chr8:124280905(-) A-I      intronic
chr8:124280864(-) A-I      intronic
chr8:124280901(-) A-I      intronic
chr8:124277329(-) A-I      intronic
chr8:124276926(-) A-I      intronic
chr8:124272258(-) A-I      intronic
chr8:124272289(-) A-I      intronic
chr8:124280869(-) A-I      intronic
chr8:124275818(-) A-I      intronic
chr8:124277346(-) A-I      intronic
chr8:124271782(-) A-I      intronic
chr8:124280076(-) A-I      intronic
chr8:124272604(-) A-I      intronic
chr8:124269372(-) A-I      intronic
chr8:124280025(-) A-I      intronic
chr8:124280119(-) A-I      intronic
chr8:124268942(-) A-I      intronic
chr8:124272588(-) A-I      intronic
chr8:124276936(-) A-I      intronic
chr8:124280074(-) A-I      intronic
chr8:124268904(-) A-I      intronic
chr8:124277019(-) A-I      intronic
chr8:124281004(-) A-I      intronic
chr8:124280092(-) A-I      intronic
chr8:124274871(-) A-I      intronic
chr8:124269296(-) A-I      intronic
chr8:124274813(-) A-I      intronic
chr8:124279985(-) A-I      intronic
chr8:124276962(-) A-I      intronic
chr8:124280072(-) A-I      intronic
chr8:124268970(-) A-I      intronic
chr8:124280202(-) A-I      intronic
chr8:124277307(-) A-I      intronic
chr8:124280159(-) A-I      intronic
chr8:124280983(-) A-I      intronic
chr8:124282849(-) A-I      intronic
chr8:124281005(-) A-I      intronic
chr8:124276968(-) A-I      intronic
chr8:124280925(-) A-I      intronic
chr8:124268838(-) A-I      intronic
chr8:124280988(-) A-I      intronic
chr8:124280935(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZHX1
chr8:124262264-124262265(-) m6A 3'UTR//exon       27773535
chr8:124262280-124262281(-) m6A 3'UTR//exon       27773535
chr8:124262342-124262343(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr8:124262356-124262357(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr8:124262394-124262395(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr8:124262417-124262418(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085
chr8:124264758-124264759(-) m6A 3'UTR//intron       27773535
chr8:124264798-124264799(-) m6A 3'UTR//intron       27773535
chr8:124265504-124265505(-) m6A 3'UTR//intron       24209618//24981863//27773535//22608085
chr8:124265609-124265610(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085
chr8:124265632-124265633(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22608085
chr8:124265723-124265724(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr8:124265780-124265781(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr8:124265790-124265791(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr8:124265842-124265843(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr8:124265848-124265849(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr8:124265870-124265871(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr8:124265877-124265878(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr8:124265921-124265922(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr8:124265945-124265946(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr8:124266030-124266031(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085
chr8:124266057-124266058(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085
chr8:124266082-124266083(-) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22608085
chr8:124266142-124266143(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085
chr8:124266184-124266185(-) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085
chr8:124266247-124266248(-) m6A CDS//intron       24209618//24981863//27773535//22608085
chr8:124266368-124266369(-) m6A CDS//intron       27773535//22608085
chr8:124266373-124266374(-) m6A CDS//intron       27773535//22608085
chr8:124266460-124266461(-) m6A CDS//intron       24284625//24981863//26404942//27773535//22608085
chr8:124266550-124266551(-) m6A CDS//intron       24284625//24981863//26404942//27773535//22575960//22608085
chr8:124266564-124266565(-) m6A CDS//intron       24284625//24981863//26404942//27773535//22575960//22608085
chr8:124266698-124266699(-) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr8:124266772-124266773(-) m6A CDS//intron       24284625//24981863//26404942//27773535//27371828//22608085
chr8:124266804-124266805(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr8:124266817-124266818(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr8:124266824-124266825(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr8:124266868-124266869(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr8:124266976-124266977(-) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22608085
chr8:124267027-124267028(-) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr8:124267090-124267091(-) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr8:124267111-124267112(-) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr8:124267124-124267125(-) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr8:124267156-124267157(-) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:124267172-124267173(-) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22608085
chr8:124267208-124267209(-) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22608085
chr8:124267467-124267468(-) m6A CDS//intron       24284625//24981863//26404942//27773535//22608085
chr8:124267536-124267537(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr8:124267541-124267542(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr8:124267645-124267646(-) m6A CDS//intron       24284625//24981863//27773535//22608085
chr8:124267751-124267752(-) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:124267762-124267763(-) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:124267910-124267911(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22608085
chr8:124267951-124267952(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22608085
chr8:124268010-124268011(-) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22608085
chr8:124268067-124268068(-) m6A CDS//exon//intron       24209618//24981863//27773535//22608085
chr8:124268124-124268125(-) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr8:124268135-124268136(-) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr8:124268243-124268244(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr8:124268250-124268251(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr8:124268278-124268279(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr8:124268287-124268288(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr8:124268308-124268309(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr8:124269334-124269335(-) m6A exon//intron       24284625//24209618//22608085
chr8:124279537-124279538(-) m6A 5'UTR//exon       24209618
chr8:124279574-124279575(-) m6A 5'UTR//exon       24209618
chr8:124279602-124279603(-) m6A 5'UTR//exon       24209618
chr8:124279619-124279620(-) m6A 5'UTR//exon       24209618
chr8:124286056-124286057(-) m6A exon//intron       24209618

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
ZHX1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: ZHX1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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