Detail Information

Basic Information:


  VIRBase ID:  

HHID00010426

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-27b-5p:           SIGMAR1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-27b-5p SIGMAR1
miRBase
Accession/Entrez ID		 MIMAT0004588 10280
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ALS16//DSMA2//hSigmaR1//OPRS1//SIG-1R//sigma1R//SR-BP//SR-BP1//SRBP

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-27b-5p
rs1427122962 chr9:95085474    G/T
rs746975163 chr9:95085473    T/C
rs1232338919 chr9:95085466    G/A
rs763344276 chr9:95085469    T/C
rs773727004 chr9:95085467    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SIGMAR1
chr9:34634890-34634891(-) m6A 3'UTR       27773535
chr9:34634915-34634916(-) m6A 3'UTR       27773535
chr9:34634966-34634967(-) m6A 3'UTR       27773535
chr9:34635269-34635270(-) m6A 3'UTR       24284625//26404942//27773535
chr9:34635344-34635345(-) m6A 3'UTR       24284625//26404942//27773535
chr9:34635409-34635410(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr9:34635427-34635428(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr9:34635445-34635446(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:34635454-34635455(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:34635464-34635465(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:34635472-34635473(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr9:34635537-34635538(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr9:34635543-34635544(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr9:34635595-34635596(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr9:34635607-34635608(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr9:34635635-34635636(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr9:34635716-34635717(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr9:34635800-34635801(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960
chr9:34636773-34636774(-) m6A exon//intron       24284625//27773535
chr9:34636793-34636794(-) m6A exon//intron       24284625//27773535
chr9:34636798-34636799(-) m6A exon//intron       24284625//27773535
chr9:34636825-34636826(-) m6A exon//intron       24284625//27773535
chr9:34637193-34637194(-) m6A exon//intron       24284625//22575960
chr9:34637410-34637411(-) m6A 5'UTR//CDS//exon       24284625//27773536//22575960
chr9:34637459-34637460(-) m6A 5'UTR//exon//intron       24284625//27773536
chr9:34637466-34637467(-) m6A 5'UTR//exon//intron       24284625//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-27b-5p
Exosome Breast milk     22211110
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
SIGMAR1
Cytosol HCC cell line (HepG2)     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-27b-5p
Progesterone 5994 Drug interaction    RC00006922
5-Fluorouracil 3385 Drug interaction    RC00006921
Lenalidomide 216326 Drug interaction    RC00006923
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-27b-5p
Cisplatin 5702198       26676926
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-27b-5p
Interactor2: SIGMAR1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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